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Maternal tmprss6 gene polymorphism rs855791SNP in Women with Preeclampsia

Journal of Biosciences and Medicines 2023年第1期11卷 70-81页

作者： Yasir I. B. Ahmed Hind S. Yagoub Mohamed A. Hassan Department of Haematology and Immunohematology Faculty of Medical Laboratory Sciences Omdurman Islamic University Omdurman Sudan Department of Medical Laboratory Technology College of Applied Medical Sciences Taibah University Medina Saudi Arabia Africa City of Technology Khartoum Sudan

Introduction: Preeclampsia can lead to several maternal and perinatal adverse effects. There are few published data on the association between transmembrane serine protease 6 (tmprss6) gene polymorphism and preeclampsia. Objective: To assess the association between tmprss6 gene polymorphism rs855791SNP in women with preeclampsia compared with healthy pregnant women. Method: A case-control study (60 women in each arm) was conducted at Saad Abuaela Maternity Hospital in Khartoum, Sudan. Sociodemographic and clinical data were gathered through a questionnaire. The participant was genotype for tmprss6 gene rs855791SNP using Polymerase Chain Reaction and Restriction Fragment Length polymorphism (PCR-RFLP). The results were confirmed by DNA sequencing. Result: There was no significant difference in the median of age, parity, and body mass index. The distribution of the genotypes and alleles of tmprss6 rs855791 was consistent with the HWE. The overall tmprss6 rs855791 polymorphism was not significantly associated with preeclampsia. However, the proportion of heterozygotes (TC) was considerably higher in the women with preeclampsia (46.7%) than in the control group (23.3%) (p = 0.001;OR = 2.71;95% CI = 1.21 - 6.07). The proportion of homozygotes (TT) and T alleles was not significantly different between women with preeclampsia and the control group. Conclusion: The overall tmprss6 rs855791 polymorphism was not significantly associated with preeclampsia and healthy control.

关键词： Preeclampsia tmprss6 gene polymorphism rs855791SNP

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