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THE SYNTHESIS OF 4,5-BIS(4'-BROMOBENZYLTHIODITHIOLE-2-thione WITH ONE DIMENSIONAL INTERMOLECULAR INTERACTIONS

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Chinese Chemical Letters 1996年第2期7卷 103-104页

作者： Fang QI(Institute of Crystal Materials, Shandong University, Jinan, 250100) Institute of Crystal Materials Shandong University Jinan 250100 China

The title compound BBBT-Dry (C17H12Br2S5, Mr=536.42) has been synthesized and its structure feature has been described. BBBT-DTT is characterized by one dimensional chains formed by S…S (head to head) and Br…Br (tai... 详细信息

关键词： BIS thione WITH INTERMOLECULAR INTERACTIONS OF SYNTHESIS DITHIOLE DIMENSIONAL BROMOBENZYLTHIO

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STUDIES ON DERIVATIVES OF 2,3-DIHYDRO-4H-1,3,2-BENZOXAZAPHOSPHORINE——SYNTHESIS AND STRUCTURE ANALYSIS OF 2,3-DISUBSTITUTED-2, 3-DIHYDRO-4H-1,3,2-BENZOXAZAPHOSPHORIN-4-ONE-(thione)-2-SULFIDE(OXIDE)

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Science in China,Ser.B 1984年第11期27卷 1131-1141页

作者：杨石先陈其杰王明德吴伸董贻诚 Institute of Element-organic Chemistry Nankai University Tianjin Institute of Biophysics Academia Sinica Beijing

A series of novel organocyclophosphorus compounds including twenty-three 2, 3-disubsti-tuted-2,3-dihydro-4H-1,3,2-benzoxazaphosphorin-4-one-2-sulfide （compounds Ⅰ） and three 2, 3-disubstituted-2,3,-dihydro-4H-1,3,2-benzoxazaphosphorin-4-thione-2-oxide （compounds Ⅱ） havebeen synthesized. Their structures were determined by IR, UV, HNMR, X-ray diffractionand elemental analysis. Each of compounds Ⅰ showed a strong absorption between 1290-1319em-1 in the IR spectrum. Comprehensive studies of the spectral data and experimental re-sults indicated that this strong characteristic absorption is different from that of the P = Olinkage and thus could be considered as a result of the stretching vibration of （unsaturatedC）-N single bond. In the course of synthesis of the compounds, an abnormal productisomers could be made predominantly in yield and be readily isolated from the other byrecrystallizing for several times from appropriate solvent. Data for the melting point, IR,UV and HNMR spectra of three pairs o

关键词： NPS OC SULFIDE SYNTHESIS AND STRUCTURE ANALYSIS OF 2,3-DISUBSTITUTED-2,3-DIHYDRO-4H-1,3,2-BENZOXAZAPHOSPHORIN-4-ONE thione OXIDE STUDIES ON DERIVATIVES OF 2,3-DIHYDRO-4H-1,3,2-BENZOXAZAPHOSPHORINE

对Carrara—thione的长空气间隙正极性操作波放电模型的评论

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高压电器 1984年第1期 41-48页

作者：唐耀宗陈亚珠上海交通大学

本文对于长空气间隙的正极性操作波放电电压计算方法进行了讨论。这方法是基于当代著名的Carrara—thione临界半径理论。但是这理论在任意形状电极转化为标准电极的两个重要判据上,处理得不够恰当。影响了该理论的应用。本文对于该两个... 详细信息

本文对于长空气间隙的正极性操作波放电电压计算方法进行了讨论。这方法是基于当代著名的Carrara—thione临界半径理论。但是这理论在任意形状电极转化为标准电极的两个重要判据上,处理得不够恰当。影响了该理论的应用。本文对于该两个判据提出了修正,使得它的概念和计算方法更为完备。这样借助于优化模拟电荷法,可以计算任意形状电极的长空气间隙承受正操作波时的放电电压。计算结果和实验数据有较好的一致性。

关键词：电极表面长空气间隙操作波间隙(电器) thione Carrara 正极性

Synthesis, Crystal Structure and Anticancer Activities of Tetrahydropyrido[4,3-d]dihydropyrimidine-2-thiones

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Chinese Journal of Chemistry 2012年第10期30卷 2509-2516页

作者：丁丽薛思佳李静肖笛王晶郝志兵庞春成 Department of Chemistry College of Life and Environmental ScienceShanghai Normal UniversityShanghai 200234China

A new series of tetrahydropyrido[4,3-d]dihydropyrimidine-2-thiones （3a-3x） were designed and synthesized. Their structures were confirmed by 1H NMR, IR, MS and elemental analysis, and the conformation of compound 3j was confirmed by X-ray diffraction. Preliminary bioassays indicated that most of the target compounds presented good antiproliferative activities against leukemic K562 cells, ovarian cancer HO-8910 cells and liver cancer SMMC-7721 cells in vitro. Among them the compounds 3i and 3m afford the best activity, the IC50 of them were 3.22 and 3.65 μg/mL against leukemic K562 cells, respectively, which were lower than the anticancer drug of clini- cal practice 5-FU （IC50 = 8.56μg/mL）. Preliminary mechanism of action studies revealed that compound 3i caused DNA fragmentation and activated caspase-3/7 in leukemic K562 cells.

关键词： tetrahydropyrido[4,3-d]dihydropyrimidine thione synthesis crystal structure anticancer activities

A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents

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Science China Chemistry 2013年第7期56卷 952-969页

作者： DAMU Guri L. V. WANG QingPeng ZHANG HuiZhen ZHANG YiYi LV JingSong ZHOU ChengHe School of Chemistry and Chemical Engineering Southwest University School of Chemistry and Chemical Engineering Bijie University

A series of naphthalimide azoles as potential antibacterial and antifungal agents were conveniently and efficiently synthesized starting from commercially available 6-bromobenzo[de]isochromene-l,3-dione. All the new compounds were characterized by NMR, IR, MS and HRMS spectra. Their antimicrobial activities were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi using two-fold serial dilution technique. The biological assay indicated that most of the prepared compounds exhibited inhibition to the tested strains. In particular, the triazolium derivatives not only gave higher ef- ficacy than their corresponding precursory azoles, but also demonstrated comparable or even better potency than the reference drugs Chloromycin, Orbifloxacin and Fluconazole. Some factors including structural fragments, pH and ClogP values of the target molecules were also preliminarily discussed.

关键词： naphthalimide triazole imidazole triazolium imidazolium thiol thione antibacterial antifungal antimicrobial

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