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An R-Smad from Haemonchus contortus(Hc-DAF-8) mediates development via the tgf-β signalling pathway

An R-Smad from Haemonchus contortus(Hc-DAF-8) mediates devel...

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中国畜牧兽医学会兽医寄生虫学分会第一届青年科学家学术论...

作者： Fangfang Li Robin B.Gasser Jianan Shan Wenda Di Li He Caixian Zhou Chunqun Wang Yanqin Zhou Rui Fang Junlong Zhao Min Hu State Key Laboratory of Agricultural Microbiology Key Laboratory for the Development of Veterinary ProductsMinistry of AgricultureCollege of Veterinary MedicineHuazhong Agricultural University Melbourne Veterinary School Faculty of Veterinary and Agricultural SciencesThe University of Melbourne

Proteins of the Smad family are essential cellular mediators of the transforming growth factor-β(tgf-β) superfamily that directly transmit incoming signals from the cell surface receptors to the *** spite of their functional importance,almost nothing is known about Smad proteins in parasitic *** the present study,we identified a homologueofDAF-8 representing the receptor-regulated Smad(R-Smad) subfamily of the free-living nematode Caenorhabditis elegans,called Hc-DAF-8,in the parasitic nematode Haemonchus *** features of Hc-DAF-8(502 amino acids),including conserved R-Smad domains,and characteristic residues in the L3 loop involved in Smad-anchoring for receptor activation(SARA),are consistent with a tgf-β type I receptor-activated *** Hc-daf-8 gene was transcribed in all developmental stages of *** studied,with a high level in fourth-stage(L4) females and the highest level in adult *** ***,this protein was localised to the platymyarian muscular cells,intestine and reproductive system of L4 and adult *** assessment showed that Hc-daf-8 was able to rescue gene function in a daf-8 deficient mutant strain of ***,leading to a resumption of normal development in this free-living worm.A specific inhibitor of human Smad3(SIS3) was shown to affect *** development in *** together,these results suggest that Hc-DAF-8,encoded by the gene Hc-daf-8,is an important cellular mediator of *** development via the tgf-βsignalling *** findings underpin future explorations of this pathway in *** and other important parasitic nematodes.

关键词： Haemonchus contortus R-Smads tgf-β signalling pathway Development Gene rescue Specific inhibitor of human Smad3(SIS3)

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