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The expression dynamics of transforming growth factor-β/smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis

The expression dynamics of transforming growth factor-β/Sma...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Chao Yan Lin Wang Bo Li Bei-Bei Zhang Bo Zhang Yan-Hong Wang Xiang-Yang Li Jia-Xu Chen Ren-Xian Tang Kui-Yang Zheng Department of Pathogenic Biology and Immunology Laboratory of Infection and ImmunityXuzhou Medical College Laboratory of Parasite and Vector Biology National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention

Liver fibrosis is a hallmark of clonorchiasis suffered by millions people in Eastern Asian ***,little is known to date about the expression of transforming growth factor-p(tgf-P) and other molecules in tgf-p/smad signaling pathway which may play an important role in hepatic fibrosis caused by ***.A total of 24 mice were individually infected orally with 45 metacercariae,both experimental mice(n=8) and mocked-infected control mice(n=5) were anesthetized at 4 week post-infection(wk p.i.),8wk p.i.,and 16 wk p.i.,*** each time-point,the liver and serum from each animal were collected to analyze histological findings and various fibrotic parameters including tgf-β,tgf-β receptors and down-stream smads activation,as well as fibrosis markers *** results showed that collagen depositions indicated by hydroxyproline content and Masson’s trichrome staining were increased gradually with the development of *** levels of smad2,smad3 as well as the protein of smad3 in livers of ***-infected mice were increased after 4 wk p.i.(PO.05,compared with normal control) whereas the tgf-β,tgf-β type Ⅰ receptor(tgfβRI) and tgf-p type Ⅱ receptor(tgfβRII) mRNA expression in ***-infected mice were higher than those of normal control mice after 8 wk p.i.(Psmad4 and smad7 were peaked at 4 wk p.i.(Ptgf-Pi in serum at 8 wk *** 16 wk p.i(Ptgf-β/smad signaling pathway may be involved in liver fibrosis caused by ***.

关键词： Clonorchis sinensis Liver fibrosis Transforming growth factor-β tgf-β/smad pathway

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