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Synthesis of water-soluble cystine C_(60) derivative with catalyst and its active oxygen radical scavenging ability

Chinese Chemical Letters 2007年第1期18卷 51-54页

作者： Zhen Hu Wen Chao Guan Xiang Ying Tang Li Zhen Huang Hong Xu Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 China

A novel water-soluble cystine C60 derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide （tbah）. The product was characterized by FT-IR, UV, ^1H NMR, ^13C NMR, MS and elemental analysis. Furthermore, the scavenging ability to superoxygen anion radical O2^·- and hydroxyl radical ^·OH was studied by chemiluminescence. It was found that cystine C60 derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50% inhibition concentration （IC50） for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL, respectively.

关键词： Cystine C60 derivatives tbah Superoxygen anion radical Hydroxyl radical Chemiluminescence

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Protective effects of cystine C60 derivative on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells

Protective effects of cystine C60 derivative on hydrogen per...

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湖北省化学化工学会2006年年会暨循环经济专家论坛

作者： Zhen Hu Lizhen Huang Haiping Xing Zhou Zhu Wei Wang Wenchao Guan Departmen of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, PR China Department of Neurology,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, PR China

Oxidative stress has been considered as a major cause of cellular injuries in a variety of clinical abnormalities, especially prominent in neural diseases. One of the usable ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of some free radical scavenger. Water-soluble amino-fullerene is a novel compound that behaves as a free radical scavenger with excellent biology consistent. In the present study, we have synthesized a novel amino- fullerene derivative for the first time, and investigated the effects on hydrogen peroxide-induced oxidative stress and apoptotic death in cultured rat pheochromocytoma (PC12) cells. The product was characterized by UV, 1HNMR, 13CNMR, MS, and elemental analysis. The scavenging ability to ROS in vitro was studied by chemiluminescence. Furthermore, the results of MTT and flow cytometry (FCM) analysis has indicated that cystine C60 derivative had excellent protective effects on hydrogen peroxide-induced apoptosis in PC12 cells.

关键词： Cystine C60 derivatives tbah Chemiluminescence MTT Flow cytometry analysis Apoptosis PC12 cells

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