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Kinetically inert manganese(II)-based hybrid micellar complexes for magnetic resonance imaging of lymph node metastasis

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Regenerative Biomaterials 2023年第1期10卷 1122-1134页

作者： Kai Chen Zhongyuan Cai Yingzi Cao Lingling Jiang Yuting Jiang Haojie Gu Shengxiang Fu Chunchao Xia Su Lui QiyongGong Bin Song Hua Ai National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Huaxi MR Research Center(HMRRC) Department of RadiologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province Key Laboratory of Transplant Engineering and ImmunologyNHCResearch Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityFujianXiamen 361000China Department of Radiology Sanya People’s HospitalSanya 572000China

the localization and differential diagnosis of the sentinel lymph nodes(SLNs)are particularly important for tumor staging,surgical planning and *** this work,kinetically inert manganese(II)-based hybrid micellar complexes(MnCs)for magnetic resonance imaging(MRI)were developed using an amphiphilic manganese-based chelate(C18-PhDtA-Mn)with reliable kinetic stability and self-assembled with a series of amphiphilic PEG-C18 polymers of different molecular weights(C18En,n=10,20,50).Among them,the probes composed by 1:10 mass ratio of manganese chelate/C18En had slightly different hydrodynamic particle sizes with similar surface charges as well as considerable relaxivities(∼13 mM^(−1)s^(−1)at 1.5 t).In vivo lymph node imaging in mice revealed that the MnC MnC-20 formed by C18E20 with C18-PhDtA-Mn at a hydrodynamic particle size of 5.5 nm had significant signal intensity brightening effect and shortened t1 relaxation *** an imaging probe dosage of 125μg Mn/kg,lymph nodes still had significant signal enhancement in 2 h,while there is no obvious signal intensity alteration in non-lymphoid *** 4t1 tumor metastatic mice model,SLNs showed less signal enhancement and smaller t1 relaxation time variation at 30 min post-injection,when compared with normal lymph *** was favorable to differentiate normal lymph nodes from SLN under a 3.0-t clinical MRI *** conclusion,the strategy of developing manganese-based MR nanoprobes was useful in lymph node imaging.

关键词： kinetically inert amphiphilic manganese chelate t1 contrast agent sentinel lymph node magnetic resonance imaging

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