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Cloning,identification and bioinformatics analysis of a putative aquaporin from trichinella spiralis(tsAQP)

Cloning,identification and bioinformatics analysis of a puta...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Cui Jian-Min Zhang Nian-Zhang Li Wen-Hui Yan Hong-Bin Fu Bao-Quan State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Public Health of the Ministry of AgricultureKey Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease

Vaccination as one of prevention strategies against the trichinella spiralis infection in hosts is an ongoing ***,no ideal vaccine candidates have been identified until ***,identification of more effective antigens in essential life stages of the parasite as vaccine candidates is of *** the present study,we identified a novel aquaporin gene in ***(tsAQP),and the potential antigenicity of tsAQP was evaluated by prediction of *** results revealed that a total of11 post-translational modification(PtM) sites falling into 4 categories,including N-glycosylation sites,casein kinase Ⅱ phosphorylation sites,protein kinase C phosphorylation sites and N-myristoylation sites,were predicted in the *** belongs to membrane intrinsic protein with high hydrophobicity and the main hydrophobic domains were distributed at amino acid positions 21-43,54-71,83-91,107-121,163-174,187-200 and 242-261,up to 38.5%of the *** tsAQP protein mainly consisted of helixes(39.58%) and loops(50%).the advanced structure of tsAQP using homology modeling method showed that the protein was formed from 6 membrane-spanning domains connecting by 5 *** on these analyses,6 potential B-cell epitopes and 4 potential t-cell epitopes were further *** results suggested that tsAQP could be a promising candidate for vaccine antigen against ***.

关键词： t.spiralis Aquaporin Cloning Bioinformatics analysis

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Adaptive evolution of trichinella spiralis genes by comparative genomic analysis with related nematodes

Adaptive evolution of Trichinella spiralis genes by comparat...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Zigang Qu Wenhui Li Nianzhang Zhang Li Li Hongbin Yan tingting Li Jianmin Cui Yang Yang Wanzhong Jia Baoquan Fu State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Public Health of the Ministry of Agriculture Key Laboratory of Veterinary Parasitology of Gansu Province Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease

Background: trichinellosis is a parasitic disease of humans caused by nematodes of the genus trichinella, and cause morbidity and mortality of human globally. Deciphering processes that drive species diversity and adaptation are key to understanding parasitism and developing control strategies. the aim of the present study was to analyse adaptation evolution of trichinella spiralis genes by comparative genomic analysis with Brugia malayi, trichuris suis, Ancylostoma aceylanicum and Caenorhabditis elegans and may serve as a foundation for future investigations to understand parasite anaerobic environment adaptation at molecular levels. Method: CODEML program from the PAML package was used to infer the most likely d N/d S ratio for each pair of sequences, the ones with d N/d S ratio > 1 were considered as positive selected genes. Results: A total of 986 genes were positive selected genes(p-value t analyses showed that the positive selected genes were significantly enriched into categories including metabolic pathways(biosynthesis of secondary metabolites,microbial metabolism in diverse environments, purine metabolism, pyrimidine metabolism, starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism and carbon metabolism);signaling pathway(c AMP signaling pathway, calcium signaling pathway and c GMP-PKG signaling pathway);cytosolic DNA-sensing pathway;RNA polymerase and neuroactive ligand-receptor interaction etc. Positive selected genes in t. spiralis consisted of SPARC(secreted protein acidic and rich in cysteine) gene that correlated with angiogenesis in nurse-cell complex, chitin synthase domain protein and cuticle collagen family genes, lysosomal aspartic protease and several cysteine protease genes as well as epigenetic-related genes that participated in DNA methylation, immune-modulation genes, energy metabolisms-related genes, differentiation or genomic reprogramming genes, DNA repair protein, cyclin-related genes, respiratory

关键词： t.spiralis positive selected genes(PSGs) anaerobic environment adaptive evolution

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