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In vitro-in vivo studies on anti-trypanosomal potentials of Zapoteca portoricensis

Asian Pacific Journal of tropical Medicine 2009年第1期2卷 25-29页

作者： Nwodo NJ Omeje EO bran R Department of Pharmaceutical Chemistry University of NigeriaNsukkaNigeria Department of Medical Parasitology and Infection biology Swiss Tropical InstituteCH-4002 BaselSwitzerland

Objective:Aqueous extracts of Zapoteca portoricensis are used traditionally as antidiarrhea agent and in the treatment of diverse gastrointestinal disorders here in Nigeria specifically,the southern ***,the aqueous extract of the plant is also used traditionally as anticonvulsant,antispasmodic and in the treatment of *** too,the anti-inflammatory and antimicrobial activities of the methanol extracts of the root of Zapoteca portoricensis was *** this research,we are set to investigate the trypanocidal activity of Zapoteca ***:the methanol extract of the root of Zapoteca portoricensis was investigated for both in vitro and in vivo trypanocidal activity following established *** summary,phytochemical analysis was carried out on both the crude powdered root and on the methanol extract following standard procedures. the oral acute toxicity test(LDb>50b> ) of the crude methanol extract was determined according to the method described by Lorke（1983）.Albino mice（17g-21g） of either sex were *** methanol extract was suspended in 3%v/v tween 85 and administered orally at doses of 10 mg/kg,100 mg/kg and 1 000 mg/kg to three groups of mice（n = 3 ）.the animals were observed for 24 *** on the result obtained in this initial test,doses of 4 mg/kg,6 mg/kg,and 8 mg/kg were administered to three different *** LDb>50b> was calculated as the geometric mean of the lowest dose killing a mouse and the highest dose showing no *** invivo /in-vitro antitrypanosomal evaluations were carried out in experimental animals and tissue cell culture respectively. Results:the result of the in vitro studies shows the inhibitive concentration-50（IC-50） against trypanosoma brucei rhodesiense（***） to be 0.372 mg/kg,while the control drug melarsoprol was 0.006 mg/*** trypanosoma brucei brucei（***）,the IC-50 is 6.42 mg/kg against 0.87 of the reference drug *** cytotoxicity on L-6 c

关键词： Zapoteca portoricensis trypanocidal effects t.b.rhodensiense t.cruzi In vitro/in vivo model

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