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Basolateral Amygdala Inactivation Reduces Sexual Motivation in Male Rats during Performance of a t-maze task with a Sexual Reward

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Journal of Behavioral and Brain Science 2014年第5期4卷 223-233页

作者： Marisela Hernández-González Francisco Abelardo Robles Aguirre Miguel ángel Guevara Gina Lorena Quirarte Paulina Haro Magallanes Centro Universitario del Norte Universidad de Guadalajara Colotlán Jalisco México Instituto de Neurobiología Campus UNAM-UAQ Juriquilla Querétaro México Instituto de Neurociencias Universidad de Guadalajara Guadalajara Jalisco México

this study was aimed to determine the effect of amygdaline inactivation on the sexual motivation of male rats during a t-maze task with a sexual reward. Subjects were chronically implanted with two stainless-steel cannulae that enabled the infusion of tetrodotoxin, a sodium channel blocker, into the left and right basolateral amygdala (BLA). Animals were divided into 3 groups: saline (SS);ttX1 (tetrodotoxin at 2.5 ng);and ttX2 (tetrodotoxin at 5.0 ng). to induce a sexually-motivated state, all male rats were allowed to have an intromission with a receptive female before performing the t-maze task, after which their sexual motivation was evaluated during seven trials in which a receptive female was placed in one goal-box of the t-maze, and a non-receptive one in the other. Subjects were allowed an intromission as a sexual reward whenever they reached the goal-box containing the receptive female, but were returned to the start-box if they did not. At the end of the experiment, copulation until ejaculation was permitted. Both doses of ttX increased the time rats required to cross the maze stem during the final trials. In terms of sexual interaction, the high dose of ttX increased more markedly mount, intromission and ejaculation latencies and the number of mounts and intromissions. Overall, these results indicate that the BLA may play an important role in modulating sexual behavior, particularly in maintaining sexual motivation in successive trials in a t-maze task and during sexual interaction per se.

关键词： Basolateral Amygdala Sexual Motivation Sexual Reward t-maze tetrodotoxin Copulation Rats

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Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats

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Neural Regeneration Research 2011年第28期6卷 2211-2216页

作者： Qing Liu Wangjun Qin Min Zhang Yanting Wang Li Jing Junxu Li Jianhui Liang National Institute on Drug Dependence Peking University Beijing 100191 China Department of Physiology Tianjin Medical University Tianjin 300070 China Department of Pharmacology and toxicology School of Medicine and Biomedical Sciences University at Buffalo State University of New York Buffalo NY USA 14214

In this study, a t-maze-based frustration model in rats was established using sucrose-reward deprivation, the results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase. During the sucrose-deprivation frustration phase, both the preference for the sucrose-deprivation arm （62.5%） and time spent waiting in the sucrose-deprivation arm decreased. Acute injection of morphine increased the preference in a dose-dependent fashion, and prolonged the waiting duration in the sucrose-deprivation arm. these findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation. to further elucidate the pharmacological mechanisms involved, the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine. the results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment. these findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor.

关键词： frustration morphine sucrose reward deprivation t-maze naloxone

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"Global-first" topological properties pattern recognition in rats

"Global-first" topological properties pattern recognition in...

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中国神经科学学会第十届全国学术会议

作者： Zheng ZHOU Xue-Mei LIU Li-Ping WANG Shenzhen Key Lab of Neuropsychiatric Modulation Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Objective topologically visual perception, "global-first" topological approach,is one of the crucial theories in primitive visual *** evidence has showed that topological perception exists in human beings,mice and ***,mere is no evidence showing that it exists in *** order to reveal the ability of such perceptions being shared across the species,we used rats as our animal model to study the topological pattern recognition and explore the relevant neuronal *** A t-maze paradigm was used to train the rats to discriminate the patterns that are topologically different,and men to test several other novelty ***（1） We successfully trained the rats to discriminate the topological difference between S shape and ring;（2） During the testing phase,we demonstrated that the rats were insensitive to topological difference,but were sensitive to topologically equivalent *** Our data suggest that topological recognition exists in rats’ vision system.

关键词： topological perception rats t-maze

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