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Severe acute respiratory syndrome coronavirus 2-specific t-cell responses are induced in people living with human immunodeficiency virus after booster vaccination

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中华医学杂志(英文版) 2024年第22期137卷 2734-2744页

作者： Wang Xiuwen Li Yongzheng Jin Junyan Chai Xiaoran Ma Zhenglai Duan Junyi Zhang Guanghui Huang tao Zhang Xin Zhang tong Wu Hao Cao Yunlong Su Bin Beijing Key Laboratory for HIV/AIDS Research Sino-French Joint Laboratory for HIV/AIDS Research Clinical and Research Center for Infectious Diseases Beijing Youan Hospital Capital Medical University Beijing China Biomedical Pioneering Innovation Center (BIOPIC) Peking University Beijing China Cancer and Stem cell Biology Program Duke-NUS Medical School Singapore Changping Laboratory Beijing China

Background: t-cell-mediated immunity is crucial for the effective clearance of viral infection, but the t-cell-mediated immune responses that are induced by booster doses of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in people living with human immunodeficiency virus (PLWH) remain ***: Forty-five PLWH who had received antiretroviral therapy (ARt) for more than two years and 29 healthy controls (HCs) at Beijing Youan Hospital were enrolled to assess the dynamic changes in t-cell responses between the day before the third vaccine dose (week 0) and 4 or 12 weeks (week 4 or week 12) after receiving the third dose of inactivated SARS-CoV-2 vaccine. Flow cytometry, enzyme-linked immunospot (ELISpot), and multiplex cytokines profiling were used to assess t-cell responses at the three timepoints in this ***: the results of the ELISpot and activation-induced marker (AIM) assays showed that SARS-CoV-2-specific t-cell responses were increased in both PLWH and HCs after the third dose of the inactivated SARS-CoV-2 vaccine, and a similar magnitude of immune response was induced against the Omicron (B.1.1.529) variant compared to the wild-type strain. In detail, spike-specific t-cell responses (measured by the ELISpot assay for interferon γ [IFN-γ] release) in both PLWH and HCs significantly increased in week 4, and the spike-specific t-cell responses in HCs were significantly stronger than those in PLWH 4 weeks after the third vaccination. In the AIM assay, spike-specific CD4+ t-cell responses peaked in both PLWH and HCs in week 12. Additionally, significantly higher spike-specific CD8+ t-cell responses were induced in PLWH than in HCs in week 12. In PLWH, the release of the cytokines interleukin-2 (IL-2), tumour necrosis factor-alpha (tNF-α), and IL-22 by peripheral blood mononuclear cells (PBMCs) that were stimulated with spike peptides increased in week 12. In addition, the levels of IL-4 and IL-5 were higher in PLW

关键词： HIV People living with HIV SARS-CoV-2 vaccine t-cell responses Omicron variant

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