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Bronchial inflammatory profile in interferon-gamma-mediated immune response in asthma patients during airway response to cold stimulus

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Frigid Zone Medicine 2022年第4期2卷 244-250页

作者： Juliy M.Perelman Aleksey B.Pirogov Anna G.Prikhodko Victor P.Kolosov Far Eastern Scientific Center of Physiology and Pathology of Respiration 22 Kalinina Str.Blagoveshchensk 675000Russia

Objective:to evaluate the inflammatory pattern and the interferon(IFN)-γin the bronchial secretion of asthma patients in response to acute cold *** and methods:We enrolled 42 patients with *** assessed asthma by Asthma Control test,the lung function by spirometry before and after the bronchodilator test,followed by collecting induced *** next day,we collected exhaled breath condensate(EBC)and conducted a 3-minute isocapnic hyperventilation with cold air(IHCA),followed by collecting spontaneously produced ***:Group 1 included 20 patients with cold airway hyperresponsiveness(CAHR),and group 2 included 22 patients without *** both groups,a high level of neutrophils in bronchial secretion was observed before and after *** response to IHCA,the number of epitheliocytes in the sputum decreased to a greater extent in patients of group *** baseline epitheliocytes and the concentration of IFN-γafter IHCA had an inverse relationship(r=-0.60;P=0.017).the baseline IFN-γin EBC before and after IHCA was lower in group *** response to cold exposure directly correlated with IFN-γlevels after IHCA(Rs=0.42;P=0.014).Conclusion:In asthma patients with CAHR,there is a relationship between the persistence of mixed inflammation and the level of IFN-γin the ***-γin response to IHCA is decreased with increased cytokine utilization during cold bronchospasm,which is accompanied by the mobilization of neutrophils and the shift in the cytokine spectrum of the respiratory tract towards the t helper cells(th)1 immune response.

关键词： asthma cold airway hyperresponsiveness mixed pattern of bronchial inflammation pro-inflammatory interferon-γ t helper cells 1 immune response

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