检索结果-南通市图书馆

MSCs-laden injectable self-healing hydrogel for systemic sclerosis treatment

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第11期7卷 369-378页

作者： Min Nie Bin Kong Guopu Chen Ying Xie Yuanjin Zhao Lingyun Sun Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210002China Department of Neurosurgery Health Science CenterThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen518035China State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyTaipaMacao(SAR)China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

As a novel cellular therapy, the anti-inflammatory and immunomodulatory virtues of mesenchymal stem cells (MSCs) make them promising candidates for systemic sclerosis (SSc) treatment. However, the clinical efficacy of this stratagem is limited because of the short persistence time, poor survival, and engraftment of MSCs after injection in vivo. Herein, we develop a novel MSCs-laden injectable self-healing hydrogel for SSc treatment. The hydrogel is prepared using N, O-carboxymethyl chitosan (CS-CM) and 4-armed benzaldehyde-terminated poly-ethylene glycol (PEG-BA) as the main components, imparting with self-healing capacity via the reversible Schiff-base connection between the amino and benzaldehyde groups. We demonstrate that the hydrogel laden with MSCs not only promoted the proliferation of MSCs and increased the cellular half-life in vivo, but also improve their immune-modulating functions. The tube formation assay indicates that the MSCs could significantly pro-mote angiopoiesis. Moreover, the MSCs-laden hydrogel could inhibit fibrosis by modulating the synthesis of collagen and ameliorate disease progression in SSc disease model mice after subcutaneous injection of bleo-mycin. All these results highlight this novel MSCs-laden hydrogel and its distinctive functions in treatment of chronic SSc, indicating the additional potential to be used widely in the clinic.

关键词： Mesenchymal Stem cell Injectable Self-healing Hydrogel systemic sclerosis

systemic sclerosis with portal hypertensive ascites responded to corticosteroid treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第13期125卷 2390-2392页

作者： LENG Xiao-mei SUN Xue-feng ZHANG Xuan ZHANG Wen LI Meng-tao ZENG Xiao-feng Department of Rheumatology and Immunology Peking UnionMedical College Hospital Beijing 100730 China Department of Pulmonary Medicine Peking Union MedicalCollege Hospital Beijing 100730 China

We describe a case of systemic sclerosis （SSc） complicated with portal hypertensive ascites which did not improve with diuretics and ascitic drainage. When corticosteroid added, her ascites diminished dramatically. Though portal hypertension can be imputed to other causes, such as polycystic liver in this case, it can occur in limited SSc with positive anti-centromere antibody and respond to corticosteroid treatment.

关键词： systemic sclerosis portal hypertension corticosteroid

Causes and predictors of mortality in South Africans with systemic sclerosis

在线全文

学校读者我要写书评

暂无评论

Rheumatology & Autoimmunity 2023年第2期3卷 108-114页

作者： Zodwa Dire Claudia Ickinger Mohammed Tikly Department of Internal Medicine Faculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Division of Rheumatology Chris Hani Baragwanath Academic HospitalFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa

Background:There is a dearth of mortality data on systemic sclerosis(SSc)in sub-Saharan Africa.We undertook a retrospective study of causes and predictors of death in low-income indigent South Africans with SSc.Methods:A retrospective records review of clinicodemographic,laboratory,and outcome data of SSc patients attending a state-funded tertiary Rheumatology service in South Africa.Results:Most of the 164 patients were Black(92.7%)and female(87.8%).The mean(SD)age at diagnosis and follow-up duration were 42.6(12.9)and 5.5(5.6)years,respectively.The majority(75.6%)had diffuse cutaneous SSc(dcSSc);and digital pits/ulcers,interstitial lung disease(ILD),and pulmonary hypertension(PH)were documented in 73.6%,55.0%,and 38.3%,respectively.There were 56 known deaths and an equal number of patients were lost to follow-up.Deaths resulted from ILD complicated by PH(42.9%),infections(8.9%),cardiac disease(7.1%),and malignancies(3.6%).Estimated 5-and 10-year survival rates for patients with known outcomes were 58%and 42%,respectively.Independent predictors of death were renal dysfunction and cor pulmonale.Conclusion:Most patients in this study of South Africans had dcSSc and poor outcomes.Known deaths resulted from cardiorespiratory complications of ILD complicated by PH.Cor pulmonale and renal dysfunction were independent predictors of death.

关键词： Africa interstitial lung disease mortality pulmonary hypertension systemic sclerosis

Associations of autoantibodies and clinical profile of the patients with systemic sclerosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rheumatology & Autoimmunity 2022年第3期2卷 141-149页

作者： Shahin Mahmud Minhaj R.Choudhury Iftekhar H.Bandhan Md.Sahidul Islam MdAbu Shahin Syed A.Haq Mohammad M.Zaman Department of Clinical Neurology National Institute of Neurosciences and HospitalAgargaonDhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Data Management World Health OrganizationDhakaBangladesh Research and Publication World Health OrganizationDhakaBangladesh

Background:systemic sclerosis is characterized by the involvement of organs and the presence of specific antibodies.The objectives of this study were to identify the autoantibodies and to determine their association with the selected clinical features of the disease among Bangladeshi systemic sclerosis patients.Methods:This cross-sectional study was performed at the rheumatology outpatient clinic of Bangabandhu Sheikh Mujib Medical University.Autoantibodies against nine systemic sclerosis-specific antigens were tested using an enzyme-linked immunoassay immunoblot kit.Several clinical features of patients with positive and negative autoantibody were examined by χ^(2) or Fisher's exact tests.Results:A total of 71 patients with systemic sclerosis(66;93.0%female)were included.Their mean age at disease onset was 33.2 years.Fifty-seven(80.3%)patients had diffuse cutaneous subtype.Out of nine autoantibodies,four were positive,anti-topoisomerase-I(57.7%),anti-U1 ribonucleic protein(21.1%),anti-RNA polymerase Ⅲ(18.3%),and anticentromere antibodies(4.2%).Eleven(15.5%)patients were negative for any antibodies and 11 patients were positive for at least two autoantibodies.Anti-U3-RNP,anti-PMScl,anti-Ku,and anti-Th/To auto antibodies were absent in all patients.Anti-RNA polymerase III was associated with raised pulmonary arterial systolic pressure(PASP)and anti-U1-RNP with decreased forced vital capacity(FVC).Conclusions:Anti-topoisomerase-I was the commonest autoantibody in patients with systemic sclerosis in Bangladesh.Anti-RNA polymerase III antibody had significant association with raised PASP and anti-U1-RNP with decreased FVC.

关键词： autoantibodies clinical profile systemic sclerosis

Role of Epigenetics in the Pathogenesis of systemic sclerosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2022年第2期5卷 87-93页

作者： Chao-Fan Liu Jia-Xuan Tang Lu-Bing Zhu Ming Li Department of Dermatology Zhongshan HospitalFudan UniversityShanghai 200032China.

systemic sclerosis(SSc)is characterized by immune dysfunction,vasculopathy,chronic fibrosis of skin and internal organs with complex etiology.With the rapid development and the application in biomedicine of epigenetics,accumulating evidence has shown that epigenetics plays an important role in the pathogenesis of SSc.Environmental factors via epigenetics are needed to trigger and maintain for the disease in the subjects with genetic predisposition to SSc.The role of epigenetics in the pathogenesis of SSc includes hypermethylation of the promoter region of nitric oxide synthase and bone morphogenetic protein receptors II,up-regulation of histone deacetylases 4 and 5 expression,and down-regulation of miR-193b and miR-152 in endothelial cells inducing vascular dysfunction;DNA hypermethylation and hypoacetylation of histone H3 and H4 in Friend leukemia virus integration 1 and Kruppel-like factor 5 genes,and the abnormal expression of miR-29,miR-129-5p and miR-135b in fibroblasts causing excessive fibrosis;DNA hypomethylation in the promoter regions of CD11a and CD70 genes in CD4+T cells resulting in immune dysfunction.Studies on the role of epigenetics in SSc are of great significance for better understanding the pathogenic machanism of SSc,which is helpful to find new molecular targets for treating SSc,and consequently,improve the prognosis of SSc.

关键词： DNA methylation epigenetics fibrosis histone acetylation immune dysfunction micro RNA systemic sclerosis vasculopathy

Micro RNAs Regulating Signaling Pathways:Potential Biomarkers in systemic sclerosis

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2015年第4期13卷 234-241页

作者： Yisha Li Jing Huang Muyao Guo Xiaoxia Zuo Department of Rheumatology Xiangya Hospital Central South University

systemic sclerosis （SSc） is a multisystem fibrotic and autoimmune disease. Both genetic and epigenetic elements mediate SSc pathophysiology. This review summarizes the role of one epigenetic element, known as microRNAs （miRNAs）, involved in different signaling pathways of SSc pathogenesis. The expression of key components in transforming growth factor-β （TGF-β） signaling pathway has been found to be regulated by miRNAs both upstream and downstream of TGF-β. We are specifically interested in the pathway components upstream of TGF-β, while miRNAs in other signaling pathways have not been extensively studied. The emerging role of miRNAs in vasculopathy of SSc suggests a promising new direction for future investigation. Elu- cidation of the regulatory role of miRNAs in the expression of signaling factors may facilitate the discovery of novel biomarkers in SSc and improve the understanding and treatment of this disease.

关键词： MicroRNA systemic sclerosis Signaling pathway TGF-β Microvascular endothelialcell Toll-like receptor

Gastrointestinal manifestations of systemic sclerosis:An updated review

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第22期9卷 6201-6217页

作者： Adan Luquez-Mindiola Alexis Javier Atuesta Andres Jose Gómez-Aldana Department of Gastroenterology Gut MédicaBogota 11711 Colombia Department of Internal Medicine Universidad Nacional de ColombiaBogota 11711Colombia Department of Endoscopy Santa Fe Foundation of Bogotá(Fundación Santa Fe de Bogotá)Bogotá11711Colombia Faculty of Medicine Universidad de los AndesBogota 11711Colombia

systemic sclerosis is an autoimmune disease characterized by vascular disease,fibrosis of the skin,and internal organ dysfunction.Gastrointestinal involvement is the most frequent complication of internal organs,impacting up to 90%of patients.Gastrointestinal involvement can affect any region of the gastrointestinal tract from the mouth to the anus,with a predominance of disorders being observed at the level of the upper digestive tract.The gastrointestinal involvement primarily involves the esophagus,small bowel,and rectum.The severity of gastrointestinal involvement affects quality of life and is a marker of worse prognosis and mortality in these patients.In this review,we describe the current findings regarding gastrointestinal involvement by this entity.

关键词： systemic sclerosis Gastrointestinal Diagnosis Treatment

Adipose-derived stem cells:Pathophysiologic implications vs therapeutic potential in systemic sclerosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2021年第1期13卷 30-48页

作者： Irene Rosa Eloisa Romano Bianca Saveria Fioretto Marco Matucci-Cerinic Mirko Manetti Department of Experimental and Clinical Medicine Section of Anatomy and HistologyUniversity of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine Division of RheumatologyUniversity of FlorenceFlorence 50134Italy

Adipose-derived stem cells(ADSCs)residing in the stromal vascular fraction(SVF)of white adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in systemic sclerosis(SSc),a complex connective tissue disorder affecting the skin and internal organs with fibrotic and vascular lesions.Several preclinical and clinical studies have reported promising therapeutic effects of fat grafting and autologous SVF/ADSC-based local treatment for facial and hand cutaneous manifestations of SSc patients.However,currently available data indicate that ADSCs may represent a double-edged sword in SSc,as they may exhibit a pro-fibrotic and anti-adipogenic phenotype,possibly behaving as an additional pathogenic source of pro-fibrotic myofibroblasts through the adipocyte-to-myofibroblast transition process.Thus,in the perspective of a larger employ of SSc-ADSCs for further therapeutic applications,it is important to definitely unravel whether these cells present a comparable phenotype and similar immunosuppressive,anti-inflammatory,anti-fibrotic and pro-angiogenic properties in respect to healthy ADSCs.In light of the dual role that ADSCs seem to play in SSc,this review will provide a summary of the most recent insights into the preclinical and clinical studies employing SVF and ADSCs for the treatment of the disease and,at the same time,will focus on the main findings highlighting the possible involvement of these stem cells in SSc-related fibrosis pathogenesis.

关键词： systemic sclerosis Adipose-derived stromal vascular fraction Adiposederived stem cells Therapeutic approaches Pathogenesis Adipocyte-to-myofibroblast transition

Expression of MMP-9 and TIMP-1 in Lesions of systemic sclerosis and Its Implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第4期28卷 480-482页

作者：孟赤陈旭娥李家文吴艳刘厚君 Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology Department of Dermatology Guizhou Provincial People's Hospital

In order to investigate the role of MMP-9 and TIMP-1 in the pathogenesis of systemic sclerosis, the expression of MMP-9 and TIMP-1 was immunohistochemically detected in skin lesions of the patients with diffuse cutaneous systemic sclerosis, skin lesions of the patients with limited cutaneous systemic sclerosis, and skin tissues of normal subjects. The results showed that the expression of MMP-9 in lesions of diffuse cutaneous systemic sclerosis was significantly lower than that of normal skins （P〈0.05）. However, no significant difference in the level of MMP-9 in the limited cutaneous systemic sclerosis and normal skin was found. Meanwhile, the expression of TIMP-1 in lesions of diffuse cutaneous systemic sclerosis and limited cutaneous systemic sclerosis were significantly higher than that of normal skins （both P〈0.05）. It was suggested that the expression of MMP-9 and TIMP-1 might play an important role in the development of systemic sclerosis.

关键词： MMP-9 TIMP-1 systemic sclerosis