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systematic investigation of Radix Salviae for treating diabetic peripheral neuropathy disease based on network Pharmacology

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World Journal of Diabetes 2024年第5期15卷 945-957页

作者： Tao Kang Xiao Qin Yan Chen Qian Yang Department of Neurology Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Diabetic peripheral neuropathy(DPN)is a debilitating complication of diabetes mellitus with limited available treatment *** Salviae,a traditional Chinese herb,has shown promise in treating DPN,but its therapeutic mech-anisms have not been systematically *** Radix Salviae(Danshen in pinin),a traditional Chinese medicine(TCM),is widely used to treat DPN in ***,the mechanism through which Radix Salviae treats DPN remains ***,we aimed to explore the mechanism of action of Radix Salviae against DPN using network *** The active ingredients and target genes of Radix Salviae were screened using the TCM pharmacology database and analysis *** genes associated with DPN were obtained from the Gene Cards and OMIM databases,a drug-com-position-target-disease network was constructed,and a protein–protein inter-action network was subsequently constructed to screen the main *** Ontology(GO)functional annotation and pathway enrichment analysis were performed via the Kyoto Encyclopedia of Genes and Genomes(KEGG)using *** A total of 56 effective components,108 targets and 4581 DPN-related target genes of Radix Salviae were *** with Radix Salviae for DPN mainly involved 81 target *** top 30 major targets were selected for enrichment analysis of GO and KEGG *** These results suggested that Radix Salviae could treat DPN by regulating the AGE-RAGE signaling pathway and the PI3K-Akt signaling ***,Danshen may affect DPN by regulating inflammation and apoptosis.

关键词： Diabetic peripheral neuropathy Radix Salviae Network pharmacology systematic investigation

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