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synthesis.and Characterization of Trithiocarbonate-Organoclays Nanohybrids and Their Interaction with MCF-7 Cancer Cells

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Journal of Chemistry and Chemical Engineering 2014年第11期8卷 1068-1081页

作者： Ulviye Bunyatova Zakir Rzayev Mustath Turk Abdullah Emur Soylemez Department of Biomedical Engineering FaculO of Engineering Baglica Campus. Baskent University Ankara 06810. Turkey Institute of Science & Engineering Division of Nanotechnology and Nanomedicine Beytepe Campus Hacettepe UniversityAnkara 06800 Turkey Department of Biology Division of Bioengineering Faculty of Science Kirikkale University Kirikkale 71450 Turkey

This work presents a new approach for the fabrication of organic/inorganic nanohybrids as anticancer drugs by an intercalation method using S,S-bis（α,α′-dimethyl-α″-acetic acid）（trithiocarbonate） as a modifier and two organoclays, such as reactive octadecylamine/MMT （montmorillonite） and non-reactive dimethyldidodecyl ammonium/MMT. The chemical and physical structures and the surface morphology of these covalently and non-covalently linked nanohybrids were investigated by FT-IR （Fourier translbrm infrared） spectroscopy, ^13C and ^29Si solid state NMR （nuclear magnetic resonance） spectroscopy, XRD （X-ray powder diffraction） and SEM （scanning electron microscopy） analyses, respectively. To evaluate the anticancer activities of the novel BATC/organoclay hybrids against MCF-7 breast cancer cells, a combination of different biochemical and biophysical testing techniques were used. Cell proliferation and cytotoxicity were detected in vitro using a real-time analysis. Cell death was confirmed by using apoptotic and necrotic analyses, the effects of which were detennined by the double staining and Annexin-V-FLUOS testing method. The results demonstrate that intercalated hybrid complexes containing a combination of various anticancer sites, such as free and complexed carboxyl, trithiocarbonate, amine and ammonium cations significantly induced cell death in breast cancer via their interactions with the DNA macromolecules of cancer cells by destroying the self-assemb｜ed structure of growing cells. Fabricated hybrid complexes may represent a new generation of effective and selective anticancer drug systems with a synthetic/natural origin for cancer chemotherapy.

关键词： synthesis. intercalating trithiocarbonate organoclays nanohybrids MCF-7 breast cancer cells real-time cytotoxicity apoptosis necrosis.

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