检索结果-南通市图书馆

FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

Bone Research 2022年第4期10卷 726-740页

作者： Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai Department of Joint Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Department of Orthopedics Orthopedic Hospital of Guangdong ProvinceAcademy of OrthopedicsGuangdong ProvinceThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina The Third School of Clinical Medicine Southern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases GuangzhouChina Department of Orthopedic Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-sen UniversityShantouChina State Key Laboratory of Organ Failure Research Department of Cell BiologySouthern Medical University School of Basic Medical SciencesGuangzhouChina

Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and ***,the effect of FABP4 on RA remains ***,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in *** increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA *** studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in *** contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in *** findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in ***309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA ***,FABP4 may represent a potential target for RA therapy.

关键词： angiogenesis inhibited synovitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint

引用

World Journal of Pediatrics 2020年第1期16卷 60-67页

作者： Mengxia Li Alexander Sauer Annette Holl-Wieden Thomas Pabst Henning Neubauer Department of Radiation Oncology University Hospital Würzburg97080 WürzburgGermany Department of Diagnostic and Interventional Radiology University Hospital Würzburg97080 WürzburgGermany Department of Pediatrics University Hospital Würzburg97080 WürzburgGermany Department of Diagnostic and Interventional Radiology University Hospital Ulm89081 UlmGermany SRH Clinic of Radiology Albert-Schweitzer-Str.298527 SuhlGermany

Background Diffusion-weighted imaging(DWI)of synovitis has been suggested as a possible non-invasive alternative to contrast-enhanced T1w imaging(ce-T1w).We aimed to study DWI for diagnosing synovitis in the knee joint of pediatric patients,to quantify inter-observer agreement on DWI and ce-T1w and to calculate quantitative measures of synovial diffusivity and *** Forty consecutive patients with known or suspected arthritis of the knee(25 girls,median age 12 years)underwent routine 1.5T MRI with ce-T1w and transverse DWI with b values 50 and 800 s/*** apparent diffusion coefficient(ADC)values and signal intensity of inflamed synovium,joint effusion and muscle were measured with regions of interest ***-contrast T1 w images(diagnostic standard)and diffusion-weighted images at b=800 s/mm2 with ADC map were separately rated by three independent and blinded readers with different levels of expertise for the presence and degree of synovitis along with the level of diagnostic *** Thirty-one(78%)patients showed at least some synovial contrast enhancement,17(43%)children were diagnosed with synovitis on *** by the 1st reader on ce-T1w and on DWI for synovitis showed very good agreement(kappa=0.90).Inter-observer agreement on DWI ranged from moderate to substantial with kappa values between 0.68 and 0.79(all P<0.001).Agreement and diagnostic confidence were generally lower in patients with mild and without synovial enhancement,compared to patients with *** yielded higher signal of inflamed synovium *** tissue,but lower signal *** effusion,compared to ce-T1 w(all P<0.001).Conclusions Diffusion-weighted imaging is a promising,though reader-dependent alternative to contrast-enhanced imaging in patients with arthritis of the knee,based on our preliminary *** holds potential for increasing patient safety and comfort.

关键词： Diffusion-weighted imaging Knee joint Magnetic resonance imaging Pediatric synovitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report

引用

World Journal of Clinical Cases 2018年第5期6卷 84-87页

作者： Tsuneaki Kenzaka Ken Goda Department of Internal Medicine Hyogo Prefectural Kaibara Hospital Division of Community Medicine and Career Development Kobe University Graduate School of Medicine

We report a case of remitting seronegative symmetrical synovitis with pitting edema(RS3 PE) syndrome in a 71-year-old woman. She referred to our hospital with finger stiffness, edema of both hands and feet, pain of bilateral shoulder, wrist, metacarpophalangeal, proximal interphalangeal, and ankle joints. Rheumatoid factor was negative, human leukocyte antigen-B7 antigen was positive. Moreover, matrix metalloproteinase 3(MMP-3) was high. She was diagnosed with RS3 PE syndrome, and treatment with prednisolone(15 mg/d) was started. One week after prednisolone treatment initiation, CRP decreased to negative, and joint pain was almost completely resolved. However, hand stiffness persisted, and MMP-3 level was still high. Thus, prednisolone dose was increased to 20 mg/d, and the stiffness resolved. Twenty days after treatment initiation, MMP-3 was normalized. MMP-3 was more indicative of RS3 PE syndrome symptoms than CRP. Thus, MMP-3 seems to be more sensitive to RS3 PE syndrome symptoms.

关键词： Serum matrix metalloproteinase 3 Remitting seronegative symmetrical synovitis with pitting edema syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerebral activation during unilateral clenching in patients with temporomandibular joint synovitis and biting pain： an functional magnetic resonance imaging study

引用

Chinese Medical Journal 2011年第14期000卷 2136-2143页

作者： ZHAO Yan-ping MA Xu-chen, JIN Zhen LI Ke LIU Gang ZENG Ya-wei Department of Oral Radiology and Center for Temporomandibular Disorders Peking University School and Hospital of StomatologyBeijing 100081 China Department of Radiology 306 Hospital of People's Liberation Army Beijing 100101 China

Background Functional magnetic resonance is a non-invasive method that can examine brain activity and has been widely used in various fields including jaw movement and pain processing. Temporomandibular disorder （TMD） is one of the most frequent facial pain problems. The objective of this study was to investigate the brain activities using functional magnetic resonance imaging （fMRI） during unilateral maximal voluntary clenching tasks in the TMD synovitis patients with biting *** Fourteen TMD synovitis patients with unilateral biting pain and 14 controls were included in the *** biting pain was defined as right molar clenching causing left temporomandibular joint （TMJ） pain. Ipsilateral biting pain was defined as right molar clenching causing right TMJ pain. Symptom Check List-90 （SCL-90） was administered to the patients and controls. Independent sample t-test was used to compare the SCL-90 subscales between the two groups. Unilateral clenching tasks were performed by the patients and controls. Imaging data were analyzed using *** Patients were divided into contralateral TMD biting pain group （n=8） and ipsilateral TMD biting pain group （n=6）. The SCL-90 subscales were significantly different between the two groups for somatization, depression, anxiety,phobic anxiety, and paranoid ideation. Group analysis of the controls demonstrated brain activations in the inferior frontal gyrus, precentral gyrus, middle frontal gyrus, superior temporal gyrus, and insular. The areas of activation were different between right and left clenching task. In TMJ synovitis patients with contralateral or ipsilateral biting pain, the group analysis showed activations in the inferior frontal gyrus, superior temporal gyrus, medium frontal gyrus, precentral gyrus,and anterior cingulate *** The inferior frontal gyrus and precentral gyrus play essential roles during the unilateral clenching *** of anterior cingulate cortex in the syno

关键词： functional magnetic resonance imaging unilateral clenching task inferior frontal gyrus precentral gyrus temporomandibular disorders synovitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy observation of chiropractic plus foot bath with Chinese medicine for transient synovitis of the hip in children

引用

Journal of Acupuncture and Tuina Science 2021年第1期19卷 37-42页

作者： Li Zhi-xing Pan Bao-hua Zhang Rui-xi Xu Yu-yu Chen Xiao-zhuan Shenzhen Traditional Chinese Medicine Hospital Guangdong ProvinceShenzhen 518033China

Objective:To compare the efficacy of different treatment protocols in treating transient synovitis of the hip(TSH)in children and to optimize the clinical treatment strategy for this ***:Ninety kids with TSH were divided into a control group,a chiropractic group and a chiropractic plus foot bath group using the random number table method,with 30 cases in each *** control group was treated with conventional traction;the chiropractic group was given chiropractic treatment based on the control group;the chiropractic plus foot bath group was given Chinese medicine foot bath based on the chiropractic *** and foot bath were conducted once daily while chiropractic was done once every other day,all with 14 d as a treatment course for a total of two *** in the visual analog scale(VAS)score and range of motion(ROM)of the hip joint in the three groups were observed,and the efficacy was ***:The total effective rate was 93.3%in the chiropractic plus foot bath group,versus 76.7%in the chiropractic group and 66.7%in the control group,and the total effective rate was notably higher in the chiropractic plus foot bath group than in the other two groups(both P<0.05).Respectively after the first and second treatment course,the VAS score decreased significantly in each of the three groups compared with that before treatment(all P<0.01),and the ROM of the hip joint in flexion increased significantly(all P<0.01).After two treatment courses,the VAS score was lower in the chiropractic plus foot bath group than in the other two groups(both P<0.05),and its ROM of the hip joint in flexion was larger than that in the other two groups(both P<0.05).Conclusion:Based on traction,chiropractic plus Chinese medicine foot bath can effectively reduce pain and improve motor function of the hip joint in treating TSH.

关键词： Chinese Therapeutic Massage(Tuina) Massage Chiropractic synovitis Steaming Washing Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Therapeutic Effect Analysis of Sodium Aescinate Tablets on Knee Osteoarthritis Combined with synovitis

引用

Journal of Clinical and Nursing Research 2021年第6期5卷 1-6页

作者： Xueqin Zeng Baohui Wang Liang Li Tao Lei Huajian Liu Yindi Sun TCM Orthopaedic Pain Ward of Rehabilitation Hospital Hong Hui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

Objective:To observe therapeutic effect of sodium aescinate Tablets on knee osteoarthritis complicated with ***:86 patients with knee osteoarthritis combined with synovitis treated in the Honghui Hospital Affiliated to Xi’an Jiaotong University from January 2018 to December 2019 were randomly divided into control group and intervention group,with 43 cases in each *** control group was given routine treatment,and the intervention group was given sodium aescinate Tablets orally on the basis of routine treatment,twice a day,2 tablets each *** curative effect was evaluated after 2 weeks of *** knee pain and joint function of the two groups were evaluated by Visual Analogue Scale(VAS)and Western Ontario and McMaster Universities Arthritis Index(WOMAC),and the clinical effects of the two groups were ***:Before treatment,there was no significant difference in general information,VAS and WOMAC scores between the two groups(P>0.05).After treatment,the VAS and WOMAC scores of the two groups were both lower than those before treatment,and the difference was statistically significant(Psynovitis can effectively alleviate knee pain,improve joint function and improve clinical efficacy.

关键词： Knee osteoarthritis synovitis Pain Knee function Quality of life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New scoring system in assessment of Hoffa's fat pad synovitis: A comparative study with established scoring systems

引用

World Journal of Radiology 2018年第11期10卷 162-171页

作者： Shigeo Hagiwara Albert Yang Shoichiro Takao Yasuhito Kaneko Taiki Nozaki Hiroshi Yoshioka Department of Radiological Sciences University of California Irvine Medical Center

AIM To investigate the reliability of the established and new scoring methods for Hoffa's fat pad synovitis using magnetic resonance imaging(MRI).METHODS A total of 139 knees of 115 patients who underwent MRI of the knee with and without gadolinium contrast were enrolled in this study. Proton density(PD)-weighted, PD-weighted fat-suppressed(PD-FS), and postcontrast T1-weighted fat-suppressed(T1CE) images were used for evaluation. Using contrast and noncontrast images, our grading method for synovitis was performed to measure synovial thickness and signal intensity changes of the fat pad [Synovial membrane(SM) score], which was compared with the established methods,including MRI Osteoarthritis Knee Score(MOAKS), parapatellar synovitis score,Whole-Organ Magnetic Resonance Imaging Score(WORMS), and suprapatellar effusion diameter. Intraclass correlation coefficients(ICC) for intra and interobserver reproducibility and Spearman correlation coefficients(r) were calculated for the parapatellar synovitis score and each scoring *** All of the scores presented substantial to almost perfect intrareliability. Among three readers, effusion diameter had substantial to almost perfect interreliability(ICC = 0.68-0.81) and WORMS had substantial interreliability(ICC = 0.61-0.70).For two out of three readers, there was substantial interreliability for the thickness score in T1CE(ICC = 0.55-0.69), SM scores in T1CE(ICC = 0.56-0.78)and PD-FS(ICC = 0.51-0.79), and parapatellar synovitis score in T1CE(ICC =0.53-0.72). The parapatellar synovitis score was significantly correlated with the thickness score in T1CE(r = 0.70) and the SM score in T1CE(r = 0.81) and PD-FS(r = 0.65).CONCLUSION The newly proposed quantitative thickness score on T1CE and the semiquantitative SM score on T1CE and PD-FS can be useful for Hoffa's fat pad synovitis.

关键词： Magnetic resonance imaging Hoffa’s fat pad synovitis Semiquantitative score Quantitative score Scoring system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful Treatment of synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome with Thalidomide: A Case Report

引用

International Journal of Dermatology and Venereology 2019年第2期2卷 99-102页

作者： Qian-Nan Xu Mu-Chi Xu Xiao-Qing Zhao Jie Zheng Hai-Qin Zhu Department of Dermatology Shanghai Ruijin Hospital NorthShanghai 201801China Department of Dermatology Shanghai Ruijin HospitalShanghai 200025China

Introductionsynovitis,Acne,Pustulosis,Hyperostosis and Osteitis (SAPHO) syndrome is a rare clinical entity characterized by a wide range of dermatological and musculoskeletal *** condition has a heterogeneous presentation,at times chronic and relapsing,which results in diagnostic difficulties and delays as well as therapeutic challenges.

关键词： Case Report synovitis Successful Treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pigmented Villonodular Tenosynovitis of the Temporomandibular Joint—A Case Report

引用

International Journal of Otolaryngology and Head & Neck Surgery 2016年第1期5卷 34-37页

作者： Satinder Singh Iram Khan Shalabh Sharma Asish K. Lahiri Department of ENT Sir Ganga Ram Hospital New Delhi India

Background: Pigmented villonodular synovitis is a rare condition typically affecting the major joints and the involvement of the temporomandibular joint is rare. Although, it is histologically benign, it can be locally aggressive, capable of extensive bone destruction. The disease has aggressive behavior and a high incidence of recurrence (40% - 60%). Case report: A 35 years old male presented with history of unilateral hearing loss and otalgia of six month duration. On examination, there was a soft bulge in the superior wall of external auditory canal. Contrast enhanced CT scan showed soft tissue density occupying the right external auditory canal and bulging into the middle ear cavity, displacing the intact ossicular chain medially with evidence of destruction of the posterior wall of the external auditory canal, glenoid fossa, mastoid bone and the scutum. The squamous part of the right temporal bone showed evidence of lateral bowing with discontinuity. Surgical resection was done through post aural approach. Histopathological examination revealed pigmented villonodular tenosynovitis which stained positive for CD 68. Post operatively patient was evaluated clinically and with radiological modalities which showed healthy mastoid cavity and no increase in post operative granulations on magnetic resonance imaging. Conclusion: Pigmented villonodular tenosynovitis of temporomandibular joint is a rare entity. Due to the aggressive behavior of the lesion, radical or aggressive surgical resection should be done. Long term follow up with radiological modality should be done due to the high recurrence rate.

关键词： Pigmented Villonodular synovitis Temporomandibular Joint Giant Cell Granuloma synovitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling

引用

Acta Pharmaceutica Sinica B 2022年第7期12卷 3073-3084页

作者： Ziying Sun Qianqian Liu Zhongyang Lv Jiawei Li Xingquan Xu Heng Sun Maochun Wang Kuoyang Sun Tianshu Shi Zizheng Liu Guihua Tan Wenqiang Yan Rui Wu Yannick Xiaofan Yang Shiro Ikegawa Qing Jiang Yang Sun Dongquan Shi State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Laboratory for Bone and Joint Disease Model Animal Research Center(MARC)Nanjing UniversityNanjing 210093China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life ScienceNanjing UniversityNanjing 210023China Drum Tower of Clinical Medicine Nanjing Medical UniversityNanjing 210008China Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Science(IMSRIKEN)Tokyo 108-8639Japan

Osteoarthritis(OA),in which M1 macrophage polarization in the synovium exacerbates disease progression,is a major cause of cartilage degeneration and functional *** strategies of OA designed to interfere with the polarization of macrophages have rarely been ***,we report that SHP099,as an allosteric inhibitor of src-homology 2-containing protein tyrosine phosphatase 2(SHP2),attenuated osteoarthritis progression by inhibiting M1 macrophage *** demonstrated that M1 macrophage polarization was accompanied by the overexpression of SHP2 in the synovial tissues of OA patients and OA model *** to wild-type(WT)mice,myeloid lineage conditional Shp2 knockout(c KO)mice showed decreased M1 macrophage polarization and attenuated severity of synovitis,an elevated expression of cartilage phenotype protein collagen II(COL2),and a decreased expression of cartilage degradation markers collagen X(COL10)and matrix metalloproteinase3(MMP3)in OA *** mechanistic analysis showed that SHP099 inhibited lipopolysaccharide(LPS)-induced Toll-like receptor(TLR)signaling mediated by nuclear factor kappa B(NF-κB)and PI3K—AKT ***,intra-articular injection of SHP099 also significantly attenuated OA progression,including joint synovitis and cartilage *** results indicated that allosteric inhibition of SHP2 might be a promising therapeutic strategy for the treatment of OA.

关键词： SHP2 SHP099 Osteoarthritis synovitis Toll-like receptor signaling Macrophage Cartilage degradation M1 macrophage polarization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：