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Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma

Cancer Innovation 2024年第2期3卷 80-95页

作者： Satoru Sasagawa Jun Kumai Toru Wakamatsu Yoshihiro Yui Molecular Biology Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan sarcoma Treatment Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Department of Musculoskeletal Oncology Service Osaka International Cancer InstituteOsakaJapan

Background:synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft tissue sarcoma with mesenchymal characteristics,associated with a poor prognosis due to frequent metastasis to a distant organ,such as the *** deacetylase(HDAC)inhibitors(HDACis)are arising as potent molecular targeted drugs,as HDACi treatment disrupts the SS oncoprotein complex,which includes HDACs,in addition to general HDACi *** provide further molecular evidence for the advantages of HDACi treatment and its limitations due to drug resistance induced by the microenvironment in SS cells,we examined cellular responses to HDACi treatment in combination with two-dimensional(2D)and 3D culture ***:Using several SS cell lines,biochemical and cell biological assays were performed with romidepsin,an HDAC1/2 selective ***38 was concomitantly used as an ameliorant drug with romidepsin ***,apoptosis induction,and MHC class I polypeptide-related sequence A/B(MICA/B)induction were monitored to evaluate the drug *** addition to the conventional 2D culture condition,spheroid culture was adopted to evaluate the influence of cell-mass microenvironment on ***:By monitoring the cellular behavior with romidepsin and/or SN38 in SS cells,we observed that responsiveness is diverse in each cell *** the apoptotic inducible cells,co-treatment with SN38 enhanced cell *** nonapoptotic inducible cells,cytostasis and MICA/B induction were observed,and SN38 improved MICA/B induction *** a novel efficacy of SN38,we revealed TWIST1 suppression in SS *** the spheroid(3D)condition,romidepsin efficacy was severely restricted in TWIST1-positive *** demonstrated that TWIST1 downregulation restored romidepsin efficacy even in spheroid form,and concomitant SN38 treatment along with romidepsin reproduced the ***:The current study demonstrated the benefits and concerns of using HDACi for SS treatment in 2D and

关键词： HDAC inhibitor MICA/B SN38 spheroid synovial sarcoma TWIST1

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Primary orbital monophasic synovial sarcoma with calcification:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1623-1629页

作者： Ming-Yu Ren Jing Li Rui-Miao Li Yi-Xiang Wu Rui-Juan Han Chi Zhang Department of Orbital Disease and Ocular Tumor Hebei Eye HospitalXingtai 054001Hebei ProvinceChina Intensive Care Unit Xingtai Third HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND synovial sarcoma is a malignant mesenchymal neoplasm with variable epithelial *** synovial sarcoma cases are reported in young adults and can arise in any body ***,primary orbital synovial sarcoma is *** SUMMARY An 8-year-old east Asian girl with 1-month history of gradual painless proptosis and lacrimation of the right eye was *** patient presented with painless proptosis,downward eyeball displacement,and upward movement *** to clinical manifestations,imaging examinations and postoperative immunohistochemical examinations,the diagnosis was monophasic synovial sarcoma with *** patient underwent anterior orbitotomy procedure for removal of the right orbital mass under general *** diagnosis of monophasic synovial sarcoma with calcification was confirmed finally through histological and immunohistochemical *** follow-up period was 6 mo,and no recurrence was observed during this *** Primary orbital monophasic synovial sarcoma with calcification is a rare sarcoma,and clinical manifestations and imaging results are not *** tumor may present similar features as a benign *** analysis of clinical,radiological,and pathological findings is critically important for making the right *** treatment approach for synovial sarcoma is surgical resection with adjuvant or neoadjuvant radiotherapy,which is highly effective for localized tumors.

关键词： Orbital tumor synovial sarcoma Calcification Histological Case report

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Primary intracranial synovial sarcoma with hemorrhage:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8871-8878页

作者： Yang-Yang Wang Man-Li Li Zhi-Yong Zhang Jiang-Wei Ding Li-Fei Xiao Wen-Chao Li Lei Wang Tao Sun Department of Neurosurgery General Hospital of Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina Sanquan College Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina

BACKGROUND synovial sarcoma(SS)is a highly malignant tumor of unknown histological *** tumor can occur in various parts of the body,including those without synovial structures,but mainly in and around the joints,mostly in the lower *** intracranial SSs are remarkably *** paper aims to report a case of primary intracranial SS with *** SUMMARY A 35-year-old male patient suffered a headache and slurred speech during manual labor and was sent to the emergency *** imaging examination,the patient was considered to have high-grade glioma complicated with hemorrhage and was treated with *** pathology revealed *** emission tomography/computed tomography was performed,which ruled out the possibility of metastasis to the intracranial from other parts of the *** radiotherapy was given to the patient,during which radiation necrosis *** months after craniotomy,cranial magnetic resonance imaging revealed recurrence of the *** Primary intracranial SS is a rare malignant *** intracranial SS with hemorrhage and radiation necrosis should be carefully monitored during postoperative *** resection of the tumor combined with postoperative radiotherapy and chemotherapy is currently used,but the prognosis is poor.

关键词： synovial sarcoma Intracranial tumor Tumor hemorrhage Case report

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synovial sarcoma IN CHILDHOOD:CLINICAL AND RADIOLOGICAL FINDINGS

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Chinese Journal of Cancer Research 1998年第2期10卷 67-70页

作者：徐德永占阿来栾红梅冯卫华孙锡和杨祖文 Department of Radiology Affiliated Hospital Qingdao Medical College Qingdao 266003 Department Zhangzhou City Hospital Fujian Department Affiliated Hospital of Weifang Medical College Shandong

Objective: To study the clinical characteristics and radiological features of synovial sarcoma in childhood and its relation to the diagnosis and treatment. Methods: The clinical radiological features of 15 children with synovial sarcoma proved surgically and pathologically were analyzed. Results: In children, the tumor boundaries are poorly defined due to paucity of fat, and metastasis usually occurs early. Eight patients in this series had bone involvement, including: direct erosion by tumor causing cortical destruction, indirect pressure defect with sharp margin and reactive bone sclerosis and bone destruction of the primary intraosseous synovial sarcoma. Conclusion: The tumor is often misdiagnosed, the final confirmed diagnosis must be made by histological examination with imaging findings. It is emphasized that the patients should be treated with radiotherapy and chemotherapy preoperatively and postoperatively.

关键词： synovial sarcoma Radiograph Diagnosis Surgery Radiotherapy Chemotherapy

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Commentary on"Primary orbital monophasic synovial sarcoma with calcification:A case report"

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World Journal of Clinical Cases 2022年第22期10卷 8054-8056页

作者： Oguzhan Tokur Sonay Aydın Erdal Karavas Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Radiology Erzincan UniversityErzincan 24100Turkey

The present letter to the editor is related to the study titled“Primary orbital monophasic synovial sarcoma with calcification:A case report”.Orbital synovial sarcoma is one of the rare intraorbital masses seen in adult and pediatric *** case reports in the literature revealed that synovial sarcoma may contain ***,it is important to make differential diagnosis among calcified orbital masses in childhood.

关键词： Orbital tumor synovial sarcoma Calcification Children Histopathology Radiology

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Testicular synovial sarcoma:A Case Report

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Clinical oncology and cancer researeh 2012年第4期9卷 274-276页

作者： Mejri Nesrine Rym Sellami Raoudha Doghri Hela Rifi Henda Raies Amel Mezlini Department of Medical Oncology Salah Azaeiz Institute Department of Pathology Salah Azaiez Institute

This paper reports a case of testicular synovial sarcoma with molecular genetic analysis. A 24-year-old male presented with painless scrotal mass. Ultrasonography showed a heterogeneous mass of 66 mm × 34 mm in size involving the inguinal region. Histological examination of a surgical biopsy showed a grade III monophasic growth pattern of spindle cell proliferation. Immunohistochemical analyses indicated positive staining for pancytokeratine and epithelial membrane antigen. Cytogenetic analysis showed the presence of CYT-SSX1 mutation, and CT scan showed non-specific pleural micro-nodules with a size of 7.5 mm. The patient had an extended left orchidectomy but was lost to follow-up for 1 year. A local recurrent scrotal mass of 32 mm ~ 25 ram, multiple inguinal lymph nodes, and increased pleural nodules, which were confirmed by histological examination, were treated with three cycles of adriamycine and ifosfamide chemotherapy, surgical resection, and radiotherapy with complete response. After 3 months, the patient developed local recurrence and pulmonary metastases that did not respond to second-line chemotherapy based on gemcitabine and paclitaxeL The patient had dyspnea at the time of this writing and chest pain, and is under third-line chemotherapy based on Deticene after 30 months of following up. This patient died on November 16, 2012 after a resperatory failure and malignant plural effusion. synovial sarcoma should be considered in the differential diagnosis of soft tissue tumor and it should be aggressively treated to improve prognosis. Although our patient has shown numerous factors of bad prognosis, he has had a relatively long survival time.

关键词： synovial sarcoma testis chemotherapy

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Clinical Pathological Analysis of synovial sarcoma

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Chinese Journal of Clinical Oncology 2007年第4期4卷 246-249页

作者： Ling Yang Bogen Song zhongjie Lin Weiming Zhang Qinhe Fan Pathology Department of Medical College Tongji University Shanghai 200092 China.

OBJECTIVE To investigate the clinical diagnosis and differential diagno- sis of synovial sarcoma (SS). METHODS A total of 41 paraffin-embedded synovial sarcoma samples were examined by H&E staining, immunohistochemistry staining and the re- verse transcriptase polymerase chain reaction (RT-PCR), in order to provide a scientific bases for diagnosis and differential diagnosis. RESULTS Twelve cases were a biphasic type, 22 cases were a mono- phasic fibrous type, and 7 cases were a poorly differentiated type. Thirty-six cases were both CK (and/or EMA) and Vim positive. Five cases were only Vim positive. A SYT-SSX fusion gene was detected in 18 cases by RT-PCR. CONCLUSION By observation of the histomorphology, immunohisto- chemistry markers and detection of a SYT-SSX fusion gene, we can make a clinical pathological diagnosis of synovial sarcoma.

关键词： synovial sarcoma clinical pathology diagnosis.

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synovial sarcoma of the parapharyngeal space:a clinicopathologic study of 5 cases and review of the literature

Synovial Sarcoma of the parapharyngeal space:a clinicopathol...

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2011国际暨全国第十一届头颈肿瘤学术大会

作者： Ming zhu1 Kejing wang1 Jinbiao Shang1 Jun li2.1. Zhejiang cancer hospital 2.the first hospital of Zhejiang province. Zhejiang cancer hospital the first hospital of Zhejiang province

synovial sarcoma usually occurs in the extremities and is rare in the head and neck. In this study, we analyzed a group of 5 synovial sarcomas arising in the Parapharyngeal space. The series comprised 5 men （100%） and no women （0%）. In common with synovial sarcoma at more conventional sites, this is a disease of youngadults:ages ranged from 22-41 years （median, 35 years）. Treatment, all 5 patients received radical excision and postoperative radiotherapy, 2 patients with pulmonary metastasis received additional *** chemotherapy included both doxorubicin and ifosfamide. Histologically, 2 examples were of monophasic type, 3 were biphasic. The tumor size ranged from 2.0 to 6.6 cm. Follow-up on 5 patients revealed that [2 were alive without disease 3.8 and 4 years respectively. 2 patients died of disease 2.2 and 3.1 years after the diagnosis respectively. 1 patient was alive with local recurrence and pulmonary metastasis]. The prognosis of synovial sarcoma in parapharyngeal space seems relatively good for those patients whose tumor size is less than 5 cm.

关键词： synovial sarcoma parapharyngeal space surgery prognostic factors

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Primary synovial sarcoma of the Kidney: A Case Report

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Journal of Cancer Therapy 2021年第10期12卷 579-584页

作者： Nouha Ammar Imene Chabchoub Rihab Ben Jaafar Hiba Sboui Makram Hochlef Faten Ezzaairi Sami Sfar Imtinane Belaid Leila Ben Fatma Manel Njim Nadia Bouzid Mohsen Belguith Rzig Ahmed Zakhama Abdelfateh Slim Ben Ahmed Medical Onocology Department University Hospital Farhat Hached Sousse Tunisia Pediatric Surgery Department University Hospital Fatouma Bourguiba Monastir Tunisia Anathomopathology Department University Hospital Fatouma Bourguiba Monastir Tunisia Radiotherapy Department University Hospital Farhat Hached Sousse Tunisia Radiology Department University Hospital Fatouma Bourguiba Monastir Tunisia

synovial sarcoma originating from the kidney is extremely rare. A 13-year-old girl presented with a mild left flank pain of one-week duration, with no associated history of hematuria or any other systemic symptoms. Computed tomography (CT) demonstrated a 6 × 13 × 9 cm mass in the left kidney. No soft tissue or extrarenal masses were identified. The patient received a combined of treatment with doxorubicin and ifosfamide. A radical nephrectomy was performed in the left kidney with no complications. Postoperative pathology revealed post-chemotherapy residue of monophasic spindle cell synovialosarcoma of the left kidney. She received a combined treatment with doxorubicin and ifosfamide in concomittance with external radiation therapy. The patient was re-examined 4 months after surgery. An abdominal and pulmonary CT found no recurrence or metastasis.

关键词： synovial sarcoma Kidney

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Massive recurrent synovial sarcoma of the neck:a case report

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The Chinese-German Journal of Clinical Oncology 2007年第4期6卷 415-416页

作者： Lei Zhang Yongguo Li Jianping Zhou Department of Geriatrics Surgery the Second Xiangya Hospital of Central-South University Changsha 410011China

We report a rare case of massive recurrent synovial sarcoma of the neck in a 25-year-old *** exami- nation showed a 30×28 cm well-defined subcutaneous mass in the left cervical region,compressing the trachea to the right. Systemic examination revealed no metastasis to other *** diagnosis of sarcoma was established by percutaneous needle *** of the left subclavian artery and the left external carotid artery were found to supply the tumor,their embolization successfully shrank the tumor preoperatively allowing subsequent *** analysis confirmed the diagnosis of synovial *** patient was without recurrence 12 months after operation.

关键词： synovial sarcoma recurrence

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