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syncytiotrophoblast Derived Extracellular Vesicles in Relation to Preeclampsia

Maternal-Fetal Medicine 2021年第2期3卷 151-160页

作者： William R.Cooke Gabriel D.Jones Christopher W.G.Redman Manu Vatish Nuffield Department of Women’s and Reproductive Health University of OxfordOxfordOX39DUUK

The syncytiotrophoblast,a fused single-cell layer between mother and fetus,constitutively releases extracellular vesicles(STBEV)directly into the maternal *** contain a variety of proteins and RNA which can be targeted to specific *** preeclampsia,asymptomatic placental oxidative stress is a precursor to later multi-organ dysfunction in the *** STBEV release in preeclampsia is considered a manifestation of syncytiotrophoblast stress,which may play a key role in signaling between fetus and *** release in preeclampsia changes,both in terms of volume and *** this review,we outline the latest advances in STBEV isolation and *** consider evidence for differential STBEV release,protein cargo and RNA content in preeclampsia,highlighting common pitfalls in study *** summarise studies to date demonstrating STBEV actions on target ***,we consider how STBEV fit into the pathophysiology of the heterogeneous syndrome of *** key unifying concept in early-and late-onset preeclampsia is syncytiotrophoblast *** submit that STBEV are the key stress signal in *** believe that further investigation of STBEV release,content,and actions may offer valuable insights into preeclampsia pathophysiology and potential new clinical diagnostics and therapeutic targets.

关键词： Biomarkers Diagnostics Extracellular vesicles Placenta Preeclampsia Signalling Stress syncytiotrophoblast

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Relationship of Abortion and the Expression of Indoleamine 2,3- dioxygenase (IDO) in Villus and syncytiotrophoblasts

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Journal of Reproduction and Contraception 2005年第4期16卷 235-242页

作者： Xue-lian LI Sui-qi GUI Hai-yan WANG Department of Gynecology of lntegrated Traditional Chinese and Western Medicine The Hospital of Obstetric ＆ Gynecology Fudan University Shanghai 200011 China

Objective To study the relationship of abortion and the expression of indoleamine 2, 3- dioxygenase （IDO） in villus and syncytiotrophoblast in vitro. Methods RT-PCR was applied to analyze the mRNA transcription of lDO in villus of normal pregnancy and inevitable abortion and JAR cells as well. Immunohistochemistry was applied to analyze the expression of IDO protein in villus. Western blot was applied to determinate the expression of IDO protein on cultured syncytiotrophoblast. Highperformance liquid chromatography was applied to determinate whether there was kynurenine in cell culture medium of syncytiotrophoblast. Results The expression of IDO mRNA and protein in villus of inevitable abortion was lower than that of normal pregnancy; IDO mRNA did not express in JAR cells. IDO protein expressed on cultured syncytiotrophoblast, and there was kynurenine in cell culture medium of syncytiotrophoblast. Conclusion Appropriate expression of IDO in villus is *** maintenance of normal pregnancy and an active IDO protein expresses in syncytiotrophoblast.

关键词： indoleamine 2,3-dioxygenase syncytiotrophoblast villus abortion

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