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synchronous primary cancers of the endometrium and ovary： review of 43 cases

The Chinese-German Journal of Clinical Oncology 2009年第2期8卷 95-99页

作者： Shaokang Ma Hongtu Zhang Yangchun Sun Lingying Wu Department of Gynecologic Oncology Caner Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 China Department of Pathology Caner Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 China

Objective： To investigate the clinical and pathological characteristics, treatment methods, and prognosis of synchronous primary cancer of the endometrium and ovary. Methods： The clinical data of 43 patients with synchronous primary cancer of endometrium and ovary were retrospectively reviewed. The survival was calculated by Kaplan-Meier method and compared using the log-rank test. Results： The median age of the patients at diagnosis was 49 years （range, 28-73 years）. The most common symptoms were abnormal vaginal bleeding （69.8%） and abdominal or pelvic pain （44.2%）. Pelvic masses were found in 39.5% of the patients and enlarged corpus in 27.9% at physic examination, while pelvic masses were found in 67.4% of the 43 patients （29 cases） and thickening or abnormal endometrium in 23.3% （10 cases） during ultrasound examination. Of 25 patients examined by CT/MRI, pelvic masses were found in 13 cases and enlarged uterus in 11 cases. All 15 patients who underwent endometrial biopsies were proven to have endometrioid carcinomas. Serum CA125 level was found to be elevated in 22 of the 34 examined cases （64.7%） with median value 500 U/mL （range, 39-3439 U/mL）. FIGO stages of endometrial carcinomas： IA 18 cases, IB 20 cases, IC 2 cases, and ⅡA 3 cases; Stages of ovarian carcinomas： IA 19 case, IB 4 cases, IC 7 cases, Ⅱ 4 cases, and ⅢC 9 cases. Twenty-four patients （55.8%） were in stage I both endometrial and ovarian carcinomas. Thirty-one patients underwent total hysterectomy plus bilateral salpingo-oophorectomy with omentectomy and appendectomy, meanwhile, 12 patients had pelvic lymph nodes dissection. Thirty-eight of the 43 patients （88.4%） had a pathologically proven endometrial adenocarcinomas. The predominant ovarian histologies were endometrioid or mixed tumors with endometrioid components （30/43, 69.8%）. Postoperatively, 26 patients （60.5%） received adjuvant chemotherapy alone, 12 had chemotherapy plus radiotherapy, only one patients had radiation alone and the remaini

关键词： endometrial neoplasms ovary neoplasms synchronous primary cancer therapy prognosis

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synchronous endometrial and ovarian cancer: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4341-4349页

作者： DianaŽilovič RūtaČiurlienė EvelinaŠidlovska Ieva Vaicekauskaitė Rasa Sabaliauskaitė Sonata Jarmalaitė Department of Oncogynecology National Cancer InstituteVilnius 08406Lithuania Institute of Biosciences Vilnius UniversityVilnius 10222Lithuania Laboratory of Clinical Oncology National Cancer InstituteVilnius 08406Lithuania National Center of Pathology Affiliate of Vilnius University Hospital Santaros KlinikosVilnius 08406Lithuania Laboratory of Genetic Diagnostic National Cancer InstituteVilnius 08406Lithuania

BACKGROUND synchronous endometrial and ovarian cancer(SEOC)is a rare genital tract *** diagnosis is crucial for the disease management since prognosis and overall survival differ substantially between metastatic endometrial cancer(EC)or *** this review we present 2 cases of women who were diagnosed with SEOC,and discuss the clinical characteristic of SEOC,diagnostic and molecular profiling *** generation sequencing of 10 gene panel was performed on cancerous tissue and uterine lavage *** SUMMARY In our report patients with SEOC had endometroid type histology with early stage and low-grade histology for both EC and *** underwent surgical treatment and ***-generation sequencing of 10 gene-panel identified CTNNB1,PIK3CA,and PTEN gene mutations in ovarian tissue in one case,while none of these genes were mutated in other *** review in support to our data suggest a good prognosis for SEOC diagnosed at early *** Accurate diagnosis of SEOC is essential for disease management and gene mutation analysis can be helpful as a complementary diagnostic and prognostic tool.

关键词： Ovarian cancer Endometrial cancer synchronous primary cancer Uterine lavage Case report

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