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Role of presynaptic phosphoprotein synapsin ⅱ in schizophrenia

World Journal of Psychiatry 2015年第3期5卷 260-272页

作者： Luke Molinaro Patricia Hui Mattea Tan Ram K Mishra Department of Psychiatry and Behavioural Neurosciences Mc Master University

synapsin ⅱ is a member of the neuronal phosphoprotein family. These phosphoproteins are evolutionarily conserved across many organisms and are important in a variety of synaptic functions, including synaptogenesis and the regulation of neurotransmitter release. A number of genome-wide scans, meta-analyses, and genetic susceptibility studies have implicated the synapsin II gene(3p25) in the etiology of schizophrenia(SZ) and other psychiatric disorders. Further studies have found a reduction of synapsin II m RNA and protein in the prefrontal cortex in post-mortem samples from schizophrenic patients. Disruptions in the expression of this gene may cause synaptic dysfunction, which can result in neurotransmitter imbalances, likely contributing to the pathogenesis of SZ. SZ is a costly, debilitating psychiatric illness affecting approximately 1.1% of the world's population, amounting to 51 million people today. The disorder is characterized by positive(hallucinations, paranoia), negative(social withdrawal, lack of motivation), and cognitive(memory impairments, attention deficits) symptoms. This review provides a comprehensive summary of the structure, function, and involvement of the synapsin family, specifically synapsin II, in the pathophysiology of SZ and possible target for therapeutic intervention/implications.

关键词： synapsin ⅱ Schizophrenia Dopamine Glutamate Neuropsychiatry Antipsychotic drugs

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The Role of synapsins in Neurological Disorders

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Neuroscience Bulletin 2018年第2期34卷 349-358页

作者： Fatima Javed Mirza Saadia Zahid Neurobiology Research Laboratory Department of Healthcare Biotechnology Atta-ur-Rahman School of Applied Biosciences National University of Sciences and TechnologyIslamabad Pakistan

synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication. Several studies have emphasized the importance of this multi-gene family of neuron-specific phosphoproteins in maintaining brain physiology. In the recent times, increasing evidence has established the relevance of alterations in synapsins as a major determinant in many neurological disorders. Here,we give a comprehensive description of the diverse roles of the synapsin family and the underlying molecular mechanisms that contribute to several neurological *** physiologically important roles of synapsins associated with neurological disorders are just beginning to be understood. A detailed understanding of the diversified expression of synapsins may serve to strategize novel therapeutic approaches for these debilitating neurological disorders.

关键词： synapsin Ⅰ synapsin ⅱ synapsin Ⅲ Neurological disorders

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