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The preparation and the in-vitro pharmacodynamics study of the intracapsular sustained-release preparations for the prevention of posterior capsule opacification

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Asian Journal of Pharmaceutical Sciences 2013年第4期8卷 252-260页

作者： Qian Dong Shaoling Yi Zihang Peng Chunshun Zhao Sun Yat-sen University Guangzhou 510006China Guangdong Food and Drug Vocational College Guangzhou 510520China

Docetaxel-loaded sustained-release preparation based on 2-Hydroxyethyl methacrylate(HEMA)and Methyl methacrylate(MMA)cross-linked copolymer(P(HEMA-co-MMA))was prepared to examine the potential use for preventing posterior capsule opacification(PCO).The preparations were prepared by polymerizing the mixture of HEMA,MMA,cross-linking agent(EGDMA),initiator(AIBN)and *** influence factors and mechanism of drug release were studied in the ***-IR,X-RD and SEM methods were used to characterize the polymer(P(HEMA-co-MMA))and docetaxel-loaded sustained-release *** of P(HEMA-co-MMA)and in-vitro effect of docetaxel-loaded sustained-release preparations were also *** results showed that docetaxel could release sustainedly from these preparations prepared by cross-linking polymeriza*** the release rate could be accelerated by increasing the MMA ratio or EGDMA ratio of the *** mechanism of docetaxel fitted the Higuchi model *** results of IR and X-RD showed that only a hydrogen bond was formed between docetaxel and P(HEMA-co-MMA).Docetaxel dispersed in P(HEMA-co-MMA)in amorphous *** elution test showed that P(HEMA-co-MMA)had good biocompatibility and the in-vitro pharmacodynamics study proved that docetaxel could release stably from the preparations and inhibit HLECs’*** docetaxel-loaded sustained-release preparations proved to be a promising therapy for preventing *** results also lay a theoretical and experimental foundation for the future.

关键词： Docetaxel sustained-release preparations sustained release PCO

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