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Particuology 2024年第3期86卷 205-210页

作者： Chenjing Liang Lingling Shi Zhengguo Chen Lan Zhou Zhaoxia Zhang Guoqing Zhang School of Materials Science and Engineering Zhejiang Sci-tech UniversityHangzhouChina College of Textile Science and Engineering Zhejiang Sci-tech UniversityHangzhouChina Zhejiang Provincial Innovation Center of Advanced Textile Technology ShaoxingChina

The aim of this work is to develop a venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres(HMSMs).HMSMs were innovatively prepared with tetraethyl silicate(TEOS)as the precursor and volatile n-heptane as a soft *** obtained HMSMs show a well-defined hollow structure with an average size of 967 nm and pore volume of 0.85 cm^(3)/g,implying it is a potential drug ***,venlafaxine hydrochloride(VF)was absorbed in the HMSMs with a content of 37.67% or *** sustained release effect is further measured by the dissolution in-strument at 37℃ and 50 rpm in ultrapure *** results showed that the HMSMs/VF system shows good sustained release properties compared with sustained release tablets with hydroxypropyl meth-ylcellulose as the main *** HMSMs sustained release system appears to be a promising candidate for a sustained drug release.

关键词： Hollowmesoporous silica microspheres(HMSMs) Venlafaxine hydrochloride Drug loading sustained release

Injectable body temperature responsive hydrogel for encephalitis treatment via sustained release of nano-anti-inflammatory agents

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Biomaterials Translational 2024年第3期5卷 300-313页

作者： Yuqi Gai Huaijuan Zhou Yingting Yang Jiatian Chen Bowen Chi Pei Li Yue Yin Yilong Wang Jinhua Li School of Medical Technology Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijingChina Beijing Institute of Technology ZhuhaiBeijing Institute of Technology(BIT)ZhuhaiGuangdong ProvinceChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Advanced Biotechnology&Medicine Rutgers UniversityPiscatawayNJUSA

Skull defects are common in the clinical practice of neurosurgery,and they are easily complicated by encephalitis,which seriously threatens the life and health safety of *** treatment of encephalitis is not only to save the patient but also to benefit the *** on the advantages of injectable hydrogels such as minimally invasive surgery,self-adaptation to irregularly shaped defects,and easy loading and delivery of nanomedicines,an injectable hydrogel that can be crosslinked in situ at the ambient temperature of the brain for the treatment of encephalitis caused by cranial defects is *** hydrogel is uniformly loaded with nanodrugs formed by cationic liposomes and small molecule drugs dexmedetomidine hydrochloride(DEX-HCl),which can directly act on the meninges to achieve sustained release delivery of anti-inflammatory nanodrug preparations and achieve the goal of long-term anti-inflammation at cranial *** is the first time that DEX-HCl has been applied within this therapeutic system,which is ***,this study is expected to alleviate the long-term suffering of patients,improve the clinical medication strategies for anti-inflammatory treatment,promote the development of new materials for cranial defect repair,and expedite the translation of research outcomes into clinical practice.

关键词： anti-inflammatory nanomedicines cranial bone defects encephalitis injectable hydrogels sustained release

sustained release of brimonidine from polydimethylsiloxane-coating silicone rubber implant to reduce intraocular pressure in glaucoma

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Regenerative Biomaterials 2023年第1期10卷 968-979页

作者： Chang Huang Yuening Shen Yujin Zhao Zhutian Zhang Shunxiang Gao Jiaxu Hong Jianjiang Xu Qingtao Meng Xinghuai Sun Jianguo Sun Eye Institute and Department of Ophthalmology Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia Fudan UniversityShanghai 200031China Key Laboratory of Myopia Chinese Academy of Medical SciencesShanghai Key Laboratory of Visual Impairment and RestorationShanghai 200031China School of Chemical Engineering University of Science and Technology LiaoningAnshanLiaoning 114051China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032China

Glaucoma is the leading cause of irreversible blindness,affecting 111 million people by 2040 *** pressure(IOP)is the only controllable risk factor for the disease and current treatment options seek to reduce IOP via daily taking eye ***,shortcomings of eye drops,such as poor bioavailability and unsatisfied therapeutic effects,may lead to inadequate patient *** this study,an effective brimonidine(BRI)-loaded silicone rubber(SR)implant coated with polydimethylsiloxane(BRI@SR@PDMS)is designed and fully investigated for IOP reduction *** in vitro BRI release from BRI@SR@PDMS implant reveals a more sustainable trend lasting over 1 month,with a gradually declined immediate drug *** carrier materials show no cytotoxicity on human corneal epithelial cells and mice corneal epithelial cells in *** administrated into rabbit’s conjunctival sac,the BRI@SR@PDMS implant releases BRI in a sustained fashion and effectively reduces IOP for 18 days with great *** contrast,BRI eye drops only maintain IOP-lowering effect for 6 ***,as a substitute of eye drops,the BRI@SR@PDMS implant can be applied as a promising non-invasive platform to achieve long-term IOP-lowering in patients suffering from ocular hypertension or glaucoma.

关键词： sustained release conjunctival sac implant glaucoma intraocular pressure brimonidine

sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats

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Neural Regeneration Research 2022年第9期17卷 2050-2057页

作者： Ci Li Song-Yang Liu Meng Zhang Wei Pi Bo Wang Qi-Cheng Li Chang-Feng Lu Pei-Xun Zhang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration Ministry of EducationBeijingChina National Center for Trauma Medicine BeijingChina Department of Orthopedics Beijing Jishuitan HospitalBeijingChina

Exosomes derived from mesenchymal stem cells are of therapeutic interest because of their important role in intracellular communication and biological *** the basis of previously studied nerve conduits,we designed a polydopamine-modified chitin conduit loaded with mesenchymal stem cell-derived exosomes that release the exosomes in a sustained and stable *** vitro experiments revealed that rat mesenchymal stem cell-derived exosomes enhanced Schwann cell proliferation and secretion of neurotrophic and growth factors,increased the expression of Jun and Sox2 genes,decreased the expression of Mbp and Krox20 genes in Schwann cells,and reprogrammed Schwann cells to a repair ***,mesenchymal stem cell-derived exosomes promoted neurite growth of dorsal root *** polydopamine-modified chitin conduits loaded with mesenchymal stem cell-derived exosomes were used to bridge 2 mm rat sciatic nerve *** release of exosomes greatly accelerated nerve healing and improved nerve *** findings confirm that sustained release of mesenchymal stem cell-derived exosomes loaded into polydopamine-modified chitin conduits promotes the functional recovery of injured peripheral nerves.

关键词： exosome mesenchymal stem cells modification strategy nerve conduits peripheral nerve injury peripheral nerve regeneration polydopamine reprogramming state Schwann cells sustained release

sustained release of isoniazid from polylactide microspheres prepared using solid/oil drug loading method for tuberculosis treatment

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Science China(Life Sciences) 2016年第7期59卷 724-731页

作者： Limei Zhang Ying Li Yun Zhang Chunyan Zhu Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College

Polylactide(PLA) microspheres were prepared using the solid-in-oil(S/O) spray-drying method to achieve the sustained release of a hydrophilic drug for the treatment of tuberculosis, via intratracheal instillation. Isoniazid(IN), a low-molecular-weight hydrophilic drug, was used as a model drug. The effects of various sizes of micronized IN powder, different drug/polymer ratios, spray-drying process parameters, and drug-release characteristics were studied to optimize the manufacturing parameters. A high entrapment efficiency(87.3%) was obtained using this method; furthermore, the microspheres were spherical and smooth. They were individually and homogenously distributed, with a mean diameter of 5.6 μm; furthermore, they showed a satisfactory extended sustained-release phase. After administration of the microspheres to rats, pulmonary drug concentrations were maintained at a relatively stable level for up to 4 weeks.

关键词： isoniazid polylactide microspheres sustained release solid/oil spraying method intratracheal intubation

sustained release donepezil loaded PLGA microspheres for injection:Preparation,in vitro and in vivo study

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Asian Journal of Pharmaceutical Sciences 2015年第5期10卷 405-414页

作者： Wenjia Guo Peng Quan Liang Fang Dongmei Cun Mingshi Yang Department of Pharmaceutics Shenyang Pharmaceutical University110016China Department of Pharmacy Faculty of Health and Medical SciencesUniversity of CopenhagenUniversitetsparken 22100 CopenhagenØDenmark

The purpose of this study was to develop a PLGA microspheres-based donepezil(DP)formulation which was expected to sustain release of DP for one week with high encapsulation efficiency(EE).DP derived from donepezil hydrochloride was encapsulated in PLGA microspheres by the O/W emulsion-solvent evaporation *** optimized formulation which avoided the crushing of microspheres during the preparation process was characterized in terms of particle size,morphology,drug loading and EE,physical state of DP in the matrix and in vitro and in vivo release *** microspheres were prepared successfully with average diameter of 30m,drug loading of 15.92±0.31%and EE up to 78.79±2.56%.Scanning electron microscope image showed it has integrated spherical shape with no drug crystal and porous on its *** scanning calorimetry and X-ray diffraction results suggested DP was in amorphous state or molecularly dispersed in *** Tg of PLGA was increased with the addition of *** release profile in vitro was characterized with slow but continuous release that lasted for about one week and fitted well with first-order model,which suggested the diffusion governing release *** single-dose administration of DP microspheres via subcutaneous injection in rats,the plasma concentration of DP reached peak concentration at 0.50 d,and then declined gradually,but was still detectable at 15 d.A good correlation between in vitro and in vivo data was *** results suggest the potential use of DP microspheres for treatment of Alzheimer’s disease over long periods.

关键词： Donepezil PLGA sustained release Microspheres In vitro and in vivo correlation

A Novel Nerve Guidance Conduit with sustained release of NGF Enhances Sciatic Nerve Regeneration

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 944-947页

作者：万志涛 Biomedical Materials and Engineering Center Wuhan University of Technology

Based on diffusion of nerve growth factor（NGF） from degradable material,a novel nerve guidance conduit（NGC） with sustained NGF release was prepared by embedding NGF into a degradable RGD-modified composite which has good cell affinity and *** vitro,the NGF release was quantified using enzyme-linked immunosorbent assay method,and the bioactivity of released NGF was examined by PC-12 cell *** vivo,the performance of the NGF-containing conduit was examined using rat sciatic nerve defect *** experimental results show that the NGF release process is prolonged over 30 days,and at least some degree of NGF bioactivity is preserved after the fabrication *** to the promoting effect of bioactive released NGF on nerve regeneration,the performance of NGC for nerve repair is improved *** results of this study indicate that the sustained NGF release system is suitable for peripheral nerve repair.

关键词： RGD nerve growth factor sustained release peripheral nerve injury

Cyclodextrin/polyethylenimine-based supramolecular nanoparticles for loading and sustained release of ATP

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Chinese Chemical Letters 2018年第6期29卷 989-991页

作者： Lu Liang Yong Chen Xu-Man Chen Yi Zhang Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University

A supramolecular nanoparticle that realized the loading and sustained release of ATP was successfully constructed from sulfato-b-cyclodextrin（SCD） and polyethylenimine（PEI）. The assembly and disassembly behaviors of supramolecular nanoparticle were investigated by means of Tyndall effect,UV–vis spectroscopy, dynamic light scattering（DLS）, zeta potential and transmission electron microscopy（TEM）. Significantly, the resulting nanoparticle was disrupted with the increasing of p H and recovered to the spherical nanoparticle as the p H decreased to initial value. Owing to the positive zeta potential, the supramolecular nanoparticle showed the good loading and sustained release abilities towards ATP.

关键词： Sulfato-b-cyclodextrin Polyethylenimine ATP pH-responsive sustained release

Polymeric microneedle-mediated sustained release systems: Design strategies and promising applications for drug delivery

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Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 70-86页

作者： Li Yang Yao Yang Hongzhong Chen Lin Mei Xiaowei Zeng Institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Parenteral sustained release drug formulations, acting as preferable platforms for longterm exposure therapy, have been wildly used in clinical practice. However, most of these delivery systems must be given by hypodermic injection. Therefore, issues including needle-phobic, needle-stick injuries and inappropriate reuse of needles would hamper the further applications of these delivery platforms. Microneedles (MNs) as a potential alternative system for hypodermic needles can benefit from minimally invasive and self-administration. Recently, polymeric microneedle-mediated sustained release systems (MN@SRS) have opened up a new way for treatment of many diseases. Here, we reviewed the recent researches in MN@SRS for transdermal delivery, and summed up its typical design strategies and applications in various diseases therapy, particularly focusing on the applications in contraception, infection, cancer, diabetes, and subcutaneous disease. An overview of the present clinical translation difficulties and future outlook of MN@SRS was also provided.

关键词： Transdermal drug delivery Microneedles sustained release Long-term exposure therapy

Selenized liposomes with ameliorative stability that achieve sustained release of emodin but fail in bioavailability

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Chinese Chemical Letters 2023年第1期34卷 235-238页

作者： Mujuan Zhu Shiping Zhu Qiubo Liu Yuehong Ren Zhiguo Ma Xingwang Zhang Department of Pharmaceutics School of PharmacyJinan UniversityGuangzhou 511443China Department of Chinese Traditional Medicine/Sun-Shengyun Heritage Studio of Eminent TCM Practitioner in Guangdong Province The First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

Stability of liposomes plays a crucial role in drug delivery,especially in oral *** structural modification of liposomes has been the orientation of efforts to improve their stability and enable the controllability of payload *** study reported a selenylation strategy to optimize the liposomal structure in an attempt to enhance the nanocarrier’s stability,hence the bioavailability of emodin(EM),an active compound with poor ***-loaded selenized liposomes(EM-Se@LPs)were prepared by thin film dispersion followed by in situ reduction *** results showed that EM-Se@LPs were provided with enhancive gastrointestinal stability and exhibited sustained release of drug compared with EM-loaded liposomes(EM-LPs).However,the modified liposomes with Se depositing onto the interior and exterior bilayers did not substantially facilitate absorption of *** reinforced structure of liposomes irrelevant to absorption was affirmed to be due to good stability and absorbability of EM ***,the present work provides an alternative option for stabilization of liposomes instead of conventional methods,which may be promising for oral delivery of physiologically unstable and/or poorly absorbed drugs and systemic drug delivery.

关键词： Emodin Liposomes Selenium Stability sustained release Bioavailability