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Signal Alteration of Substantia Nigra on 3.0T susceptibility-weighted Imaging in Parkinson's Disease and Vascular Parkinsonism

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Current Medical Science 2019年第5期39卷 831-835页

作者： Xue-jun ZHAO Xi-yuan NIU He-yang YOU Min ZHOU Xue-bing JI Ying LIU Lei WU Xiao-ling DING Neurocritical Care Unit The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Neurology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Recent researches have found that 7 Tesla SWI can detect the alteration of substantia nigra hyperintensity in Parkinson's disease(PD),multiple system atrophy(MSA),and progressive supranuclear palsy(PSP).The aim of this study was to investigate whether 3 Tesla SWI(3T SWI)can visualize anatomical alterations occurring in a hyperintense structure of the substantia nigra in PD and vascular parkinsonism(VP),and whether the evaluation of abnormal signal can be used as a factor in the differential diagnosis of PD and *** 3 Tesla MRI,we evaluated 38 healthy subjects,33 patients with PD and 34 patients with *** blinded readers independently assessed the *** found that the dorsolateral nigral hyperintensity was absent in 31 of 33 patients with PD and 15 of 34 patients with *** dorsolateral nigral hyperintensity was present in 19 of 34 patients with VP and 35 of 38 healthy *** comparisons of absence of dorsolateral nigral hyperintensity revealed significant differences between the patients with PD and those with VP(P<0.001).The sensitivity of SWI for PD was 93.9%and the specificity was 92.1%.Visual assessment of dorsolateral nigral hyperintensity on high-field SWI scans may serve as a new simple diagnostic imaging marker for *** our study results indicate that 3T SWI can be used as a tool to identify PD and VP.

关键词： magnetic resonance imaging susceptibility-weighted imaging Parkinson's disease vascular parkinsonism substantia nigra

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Asymmetrically hypointense veins on T2~*w imaging and susceptibility-weighted imaging in ischemic stroke

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World Journal of Radiology 2013年第4期5卷 156-165页

作者： Ulf Jensen-Kondering Ruwen Bhm Institute of Neuroradiology University of Schleswig-Holstein Campus Kiel Institute of Experimental and Clinical Pharmacology University of Schleswig-Holstein Campus Kiel

AIM:To review the literature on the assessment of venous vessels to estimate the penumbra on T2*w imaging and susceptibility-weighted imaging (SWI). METHODS:Literature that reported on the assessment of penumbra by T2*w imaging or SWI and used a validation method was included. PubMed and relevant stroke and magnetic resonance imaging (MRI) related conference abstracts were searched. Abstracts that had overlapping content with full text articles were excluded. The retrieved literature was scanned for further relevant references. Only clinical literature published in English was considered, patients with Moya-Moya syndrome were disregarded. Data is given as cumulative absolute and relative values, ranges are given where appropriate. RESULTS:Forty-three publications including 1145 patients could be identified. T2*w imaging was used in 16 publications (627 patients), SWI in 26 publications (453 patients). Only one publication used both (65 patients). The cumulative presence of hypointense vessel sign was 54% (range 32%-100%) for T2* (668 patients) and 81% (range 34%-100%) for SWI (334 patients). There was rare mentioning of interrater agreement (6 publications, 210 patients) and reliability (1 publication, 20 patients) but the numbers reported ranged from good to excellent. In most publications (n = 22) perfusion MRI was used as a validation method (617 patients). More patients were scanned in the subacute than in the acute phase (596 patients vs 320 patients). Clinical outcome was reported in 13 publications (521 patients) but was not consistent. CONCLUSION:The low presence of vessels signs on T2*w imaging makes SWI much more promising. More research is needed to obtain formal validation and quantification.

关键词： Acute ischemic stroke Oxygen extraction fraction susceptibility-weighted imaging T2* Penumbra

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Cerebral Microbleeds Identified by susceptibility-weighted Imaging in Two Cases of Fabry Disease without Neurological Symptoms

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Open Journal of Medical Imaging 2015年第4期5卷 194-198页

作者： Mineka Yamazoe Masayuki Maeda Maki Umino Hidekazu Tomimoto Hajime Sakuma Department of Radiology School of Medicine Mie University Mie Japan Department of Advanced Diagnostic Imaging School of Medicine Mie University Mie Japan Department of Neurology School of Medicine Mie University Mie Japan

Cerebrovascular disease is one of the fatal causes of Fabry disease (FD). Brain magnetic resonance imaging findings typically show lacunar infarcts in young patients with FD, but brain hemorrhages in FD are rarely reported. We report two cases of FD focusing on cerebral microbleeds (CMBs). susceptibility-weighted imaging (SWI) and T2*-weighted imaging reveal several lobar and deep CMBs in two patients with no medical history of stroke symptoms, hypertension, and anticoagulant/antiplatelet treatment. SWI can detect a greater number of CMBs than T2*-weighted imaging. Thus, SWI is an excellent tool for identifying underlying CMBs in FD.

关键词： Fabry Disease Magnetic Resonance Imaging susceptibility-weighted Imaging Cerebral Microbleeds

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Relationship of cerebral microbleeds to inflammatory marker levels

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Neuroimmunology and Neuroinflammation 2017年第8期4卷 145-151页

作者： Qiao-Li Lu Chen Li Ying Song Liang Wang Zhi-Rong Jia Department of Neurology Tianjin 5th Center HospitalTianjin 300450China Department of Neurosurgery Tianjin 5th Center HospitalTianjin 300450China Department of Neurology Peking University First HospitalBeijing 100034China

Aim: The purpose of this study is to investigate the incidence, distribution and risk factors of cerebral microbleeds (CMBs) and the relation between CMBs and inflammation in ischemic cerebrovascular disease. Methods: Two hundred and one patients without acute infarction or transient ischemic attack were enrolled. The presence and number of CMB were assessed on susceptibility-weighted imaging. The traditional risk factors of CMB were recorded. Levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) were tested. Logistic regression analyses were used for multiple-factor analysis of risk factors of CMB. Results: Of the 201 patients, 49 (24.38%) had CMB. Multivariate logistic regression analyses showed that the age, the prevalence of hypertension, silent lacunar infarction, white matter lesion, Montreal Cognitive Assessment Score, the using rate of antithrombotic drugs and levels of hs-CRP, IL-6, MMP-9 were the risk factors for CMB. After adjustments for traditional risk factors, inflammatory marker levels remained to be associated with CMBs. The adjusted odd ratios of hs-CRP, IL-6 and MMP-9 were 1.745 (1.342-2.270), 1.223 (1.018-1.533) and 1.284 (1.082-1.423), respectively. Furthermore, inflammatory marker levels were the risk factor for deep or infratentorial CMBs and lobar CMBs. Conclusion: The age, prevalence of hypertension, silent lacunar infarction, white matter lesion, MoCA Score, the using rate of antithrombotic drugs and serum hs-CRP, IL-6, and MMP-9 levels were the independent risk factors for CMBs.

关键词： Cerebral microbleed traditional risk factor inflammatory marker level susceptibility-weighted imaging

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