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A　COMPARATIVE　STUDY　ON　THERAPEUTIC　RESPONSE　AND　survival　time　OF　PATIENTS　WITH　MULTIPLE　MYELOMA　TREATED　WITH　MODIFIED　VMCP　RE

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Journal of Pharmaceutical Analysis 1996年第2期10卷 169-173页

作者：陈学民郑成云王宝燕韩云峰侯抗日邵文斌 Department of Hematology First Affiliated Hospital Xi'an Medical University Xi'an 710061 China

Therapeutic response and survival time or 43 patients with multiple myeloma treated with modified VMCP(Vincristine,Melphalan, Cyelophosphamide and perdnisone;mVMCP)multidrug regimen are analyzed,and compared with those of 41 patients treated with VACP, M2, MP and other regimens.Therapeutic response to mVMCP regimen was better than that to other combination regimens(83. 5% VS 60.9%;Psurvival time of two groups of responders was not signifficautly different(32. 5 vs 34.1 mouths; P>0.5).The prognostic significance of various pretreatment characteristics was evaluated in term of therapeutic response.The bone status and renal function had a significant inverse correlation with the survival time of patients responding to chemotherapy.Our data indicate that the patients with MM treated by mean or mVMCP regimen can obtain a better response in early treatment and maintain a longer remission duration as well as a better performance status. although the regimen can not prolong the patients survival time.

关键词： multiple myeloma combination chemotherapy survival time remission duration prognostic factor

Urinary bladder cancer as a late sequela of traumatic spinal cord injury

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Military Medical Research 2022年第1期9卷 21-31页

作者： Ralf Bthig Christian Tiburtius Wolfgang Schps Michael Zellner Oliver Balzer Birgitt Kowald Sven Hirschfeld Roland Thietje Aki Pietsch Ines Kurze Martin Forchert Thura Kadhum Klaus Golka Department of Neuro-Urology Centre for Spinal Cord InjuriesBG Klinikum Hamburg21033 HamburgGermany Urological Practice 53757 Sankt AugustinGermany Department of Urology and NeuroUrology Johannesbad Fachklinik94072 Bad FussingGermany Biomechanical Laboratory Centre for Spinal Cord InjuriesBG Klinikum Hamburg21033 HamburgGermany Centre for Spinal Cord Injuries BG Klinikum Hamburg21033 HamburgGermany Department of Sports and Rehabilitation Medicine BG Klinikum Hamburg21033 HamburgGermany Department of Paraplegiology and Neuro-Urology Centre for Spinal Cord InjuriesZentralklinik Bad Berka Berka99437 Bad BerkaGermany Staff Position Accident Insurance Law Statutory Accident Insurance for Wood and Metal(BGHM)33602 BielefeldGermany Department of Psychosomatic Rehabilitation Mittelrheinklinik Fachklinik56154 Boppard-Bad SalzigGermany Clinical Occupational Medicine Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund(IfADo)44139 Bothig et al.Mil Med Res 2021

Background:Traumatic spinal cord injury(SCI)is also a combat-related injury that is increasing in modern warfare.The aim of this work is to inform medical experts regarding the different course of bladder cancer in able-bodied patients compared with SCI patients based on the latest medical scientific knowledge,and to present decision-making aids for the assessment of bladder cancer as a late sequela of traumatic SCI.Methods:A study conducted between January 1998 and December 2019 in the BG Trauma Hospital Hamburg formed the basis for the decision-making aids.Urinary bladder cancer was diagnosed in 40 out of 7396 treated outpatient and inpatient SCI patients.General patient information,latency period,age at initial diagnosis,type of bladder management and survival of SCI patients with bladder cancer were collected and analysed.T category,grading and tumor entity in these patients were compared with those in the general population.Relevant bladder cancer risk factors in SCI patients were analysed.Furthermore,relevant published literature was taken into consideration.Results:Initial diagnosis of urinary bladder cancer in SCI patients occurs at a mean age of 56.4 years(SD±10.7 years),i.e.,approximately 20 years earlier as compared with the general population.These bladder cancers are significantly more frequently muscle invasive(i.e.,T category≥T2)and present a higher grade at initial diagnosis.Furthermore,SCI patients show a significantly higher proportion of the more aggressive squamous cell carcinoma than that of the general population in areas not endemic for the tropical disease schistosomiasis.Consequently,the survival time is extremely unfavourable.A very important finding,for practical reasons is that,in the Hamburg study as well as in the literature,urinary bladder cancer is more frequently observed after 10 years or more of SCI.Based on these findings,a matrix was compiled where the various influencing factors,either for or against the recognition of an association between SCI and urinary bladder cancer,wer

关键词： Traumatic spinal cord injury Neurogenic bladder Transitional cell carcinoma Squamous cell carcinoma survival time Battlefield injury Medical assessment

Clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study

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Emergency and Critical Care Medicine 2022年第3期2卷 109-115页

作者： Xianlong Zhou Guoyong Ding Qing Fang Jun Guo Luyu Yang Ping Wang Shou-Zhi Fu Ang Li Jian Xia Jiangtao Yu Jianyou Xia Min Ma Zhuanzhuan Hu Lei Huang Ruining Liu Cheng Jiang Shaoping Li Mingxia Yu Xizhu Xu Yan Zhao Quan Hu Weijia Xing Zhigang Zhao Emergency Center Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina School of Public Health Shandong First Medical University and Shandong Academy of Medical SciencesTai’anShandongChina Emergency Department General Hospital of Central Theater Command of PLAWuhanHubeiChina Intensive Care Unit Huazhong University of Science and Technology Union Jiangbei HospitalWuhanHubeiChina Intensive Care Unit Wuhan Third HospitalWuhanHubeiChina Department of Urology General Hospital of Central Theater Command of PLAWuhanHubeiChina Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Hubei Clinical Research Center for Emergency and Resuscitation Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Intensive Care Unit The First People’s Hospital of Jiangxia DistrictWuhanHubeiChina

Background:The coronavirus disease 2019(COVID-19)has affected approximately 2 million individuals worldwide;however,data regarding fatal cases have been limited.Objective:To report the clinical features of 162 fatal cases of COVID-19 from 5 hospitals in Wuhan between December 30,2019 and March 12,2020.Methods:The demographic data,signs and symptoms,clinical course,comorbidities,laboratory findings,computed tomographic(CT)scans,treatments,and complications of the patients with fatal cases were retrieved from electronic medical records.Results:The median patient age was 69.5(interquartile range:63.0–77.25)years,and 80%of the patients were over 61 years.A total of 112(69.1%)patients were men.Hypertension(45.1%)was the most common comorbidity,while 59(36.4%)patients had no comorbidity.At admission,131(81.9%)patients had severe or critical COVID-19,whereas 39(18.1%)patients with hypertension or chronic lung disease had moderate COVID-19.In total,126(77.8%)patients received antiviral treatment,while 132(81.5%)patients received glucocorticoid treatment.A total of 116(71.6%)patients were admitted to the intensive care unit(ICU),and 137(85.1%)patients received mechanical ventilation.Most patients received mechanical ventilation before ICU admission.Approximately 93.2%of the patients developed respiratory failure or acute respiratory distress syndrome.There were no significant differences in the inhospital survival time among the hospitals(P=0.14).Conclusion:Young patients with moderate COVID-19 without comorbidity at admission could also develop fatal outcomes.The in-hospital survival time of the fatal cases was similar among the hospitals of different levels in Wuhan.

关键词： Clinical features Coronavirus disease 2019 Fatal cases survival time

Ethanol Extract of Ilex Hainanensis Merr. Exhibits Anti-Melanoma Activity by Induction of G1/S Cell-Cycle Arrest and Apoptosis

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Chinese Journal of Integrative Medicine 2018年第1期24卷 47-55页

作者： ZHANG Ya-qi YANG Hao SUN Wei-dong WANG Juan ZHANG Bao-yuan SHEN Yan-jun YIN Min-qiang LIU Yun-xing LIU Chang SUN Yun College of Medicine Yangzhou University YangzhouJiangsu Province 225009 China College of Clinical Chinese Medicine Yangzhou University Yangzhou Jiangsu Province 225009 China Medical and Pharmaceutical Institute Yangzhou University Yangzhou Jiangsu Province 225009 China Chinese Medicine Hospital of YangzhouCity Yangzhou Jiangsu Province 225009 China Oncology Business Unit Wuxi AppTec. Inc Shanghai 200131 China

Objective： To evaluate anti-melanoma effect of ethanol extract of Ilex hainanensis Merr. （IME） and elucidate its underlying mechanism. Methods： Thirty-six tumor-bearing mice were randomized into 6 groups （n=6） as follows： model group, IME 25, 50, 100, and 200 mg/kg groups and dacarbazine （DTIC） 70 mg/kg group. The mice in the IME treatment groups were intragastrically administered with IME 25, 50, 100 or 200 mg/kg per day, respectively. The mice in the DTIC group were intraperitoneally injected with DTIC 70 mg/kg every 2 days. The drug administration was lasting for 14 days. The cell viability was evaluated by 3-（4,5-dime-thylthylthiazol-2-yl）-2, 5-diphenyl-tetrazolium bromide （MTT） assay. Flow cytometry was employed to detect cell cycle and apoptosis. The gene and protein expressions of nuclear factor κB-p65 （NF-κB-p65）, Bcl-2, B-cell lymphoma-extra large （Bcl-xL） and Bax were detected by quantitative real-time polymerase chain reaction and Western blot analyses. Caspases-3, -8, and -9 activities were detected using the colorimetric method. In addition, a B16-F10 melanoma xenograft mouse model was used to evaluate the anti-cancer activity of IME in vivo. Furthermore, a survival experiment of tumor-bearing mice was also performed to evaluate the possible toxicity of IME. Results： IME significantly inhibited the proliferation of B16-F10 cells （P〈0.01）. Flow cytometric analysis showed that IME induced G1/S cell cycle arrest and apoptosis （both P〈0.01）. IME inhibited activation of NF-κB, decreased the gene and protein expressions of Bcl-2, Bcl-xL, and increased the gene and protein expressions of Bax （all P〈0.01）. In addition, IME induced the activation of Caspases-3, -8, and -9 in B16-F10 cells. The study in vivo showed that IME significantly reduced tumor volume （P〈0.01）, and the inhibitory rate came up to 68.62%. IME also induced large areas of necrosis and intra-tumoral apoptosis that correlated with a reduction in tumor volume. survival experiment showed that treatment with IME for 14 days significantly prolong

关键词： Ilex hainanensis Merr. anti-melanoma activity G1/S arrest apoptosis survival time caspase,Chinese medicine

Application of Positron Emission Tomography in the Detection of Myocardial Metabolism in Pig Ventricular Fibrillation and Asphyxiation Cardiac Arrest Models after Resuscitation

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Biomedical and Environmental Sciences 2014年第7期27卷 531-536页

作者： WU Cai Jun LI Chun Sheng ZHANG Yi YANG Jun Department of Emergency Beijing Chaoyang HospitalCapital Medical University

Objective To study the application of positron emission tomography （PET） in detection of myocardia metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Methods Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac arrest （VFCA） group （n=16） and an asphyxiation cardiac arrest （ACA） group （n=16）. Cardiac arrest （CA） was induced by programmed electric stimulation or endotracheal tube clamping followed by cardiopulmonary resuscitation （CPR） and defibrillation. At four hours and 24 h after spontaneous circulation was achieved, myocardial metabolism was assessed by PET. 18F-FDG myocardial uptake in PET was analyzed and the maximum standardized uptake value （SUVmax） was measured. Results Spontaneous circulation was 200% and 62.5% in VFCA group and ACA group, respectively. PET demonstrated that the myocardial metabolism injuries was more severe and widespread after ACA than after VFCA. The SUVrnax was higher in VFCA group than in ACA group （P〈0.01）. In VFCA group, SUVmax at 24 h after spontaneous circulation increased to the level of baseline. Conclusion ACA causes more severe cardiac metabol associated with less successful resuscitation. Myocardial sm injuries than VFCA. Myocardial dysfunction is stunning does occur with VFCA but not with ACA.

关键词： Ventricular fibrillation Asphyxia Cardiac arrest Spontaneous circulation Positron emissiontomography Standardized uptake value survival time

Orbital metastases in Italy

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 1018-1023页

作者： Patrizio Magliozzi Diego Strianese Paola Bonavolontà Mariantonia Ferrara Pasquale Ruggiero Raffaella Carandente Giulio Bonavolontà Fausto Tranfa Department of Neuroscience Odontostomatological and Reproductive SciencesUniversity of Naples Federico Ⅱ

AIMTo describe a series of Italian patients with orbital metastasis focusing on the outcomes in relation to the different primary site of malignancy.METHODSRetrospective chart review of 93 patients with orbital metastasis collected in a tertiary referral centre in a period of 38y and review of literature.RESULTSOut of 93 patients, 52 were females and 41 were males. Median age at diagnosis was 51y (range 1 to 88y). The patients have been divided into four groups on the basis of the year of diagnosis. The frequency of recorded cases had decreased significantly (Psurvival time (OMST) after the orbital diagnosis of 13.5mo.CONCLUSIONBreast, kidney and lung are the most frequent primary sites of cancer leading to an orbital metastasis. When the primary site is unknown, gastrointestinal tract should be carefully investigated. In the last decade a decrease in the frequency of orbital metastasis has been observed. Surgery provides a local palliation. Prognosis remains poor with a OMST of 13.5mo ranging from the 3mo in the lung cancer to 24mo in the kidney tumor.

关键词： orbital metastasis primary tumor survival time

Construction of a clinical survival prognostic model for middle-aged and elderly patients with stage III rectal adenocarcinoma

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World Journal of Clinical Cases 2021年第7期9卷 1563-1579页

作者： Hao Liu Yu Li Yi-Dan Qu Jun-Jiang Zhao Zi-Wen Zheng Xue-Long Jiao Jian Zhang Department of Colonrectal Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Rheumatology and Immunology Department The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Nomograms for prognosis prediction in colorectal cancer patients are few,and prognostic indicators differ with age.AIM To construct a new nomogram survival prediction tool for middle-aged and elderly patients with stage III rectal adenocarcinoma.METHODS A total of 2773 eligible patients were divided into the training cohort(70%)and the validation cohort(30%).Optimal cutoff values were calculated using the X-tile software for continuous variables.Univariate and multivariate Cox proportional hazards regression analyses were used to determine overall survival(OS)and cancer-specific survival(CSS)-related prognostic factors.Two nomograms were successfully constructed.The discriminant and predictive ability and clinical usefulness of the model were also assessed by multiple methods of analysis.RESULTS The 95%CI in the training group was 0.719(0.690-0.749)and 0.733(0.702-0.74),while that in the validation group was 0.739(0.696-0.782)and 0.750(0.701-0.800)for the OS and CSS nomogram prediction models,respectively.In the validation group,the AUC of the three-year survival rate was 0.762 and 0.770,while the AUC of the five-year survival rate was 0.722 and 0.744 for the OS and CSS nomograms,respectively.The nomogram distinguishes all-cause mortality from cancer-specific mortality in patients with different risk grades.The time-dependent AUC and decision curve analysis showed that the nomogram had good clinical predictive ability and decision efficacy and was significantly better than the tumor-node-metastases staging system.CONCLUSION The survival prediction model constructed in this study is helpful in evaluating the prognosis of patients and can aid physicians in clinical diagnosis and treatment.

关键词： Rectal adenocarcinoma Lymph node positive rate Nomogram Prognostic model Predictive model survival time

Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis

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World Journal of Gastroenterology 2010年第11期16卷 1397-1401页

作者： Jiang, Ming Liu, Fei Xiong, Wu-Jun Zhong, Lan Xu, Wen Xu, Fei Liu, Yan-Bing Tongji Univ Shanghai E Hosp Affiliated Dept Gastroenterol Shanghai 200120 Peoples R China

AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the fi rst day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed up for 1 year. The relationship between the change of blood lipid level and the value of MELD score was studied by analysis of variance. The prognostic factors were screened by multivariate Cox proportional hazard model. Draw Kaplan-Meier survival curves were drawn. RESULTS: Forty-f ive patients died within 3 mo and 83 patients died within 1 year. The levels of TG, TC, HDL and LDL of the death group were all lower than those of the survivors. The serum TG, TC, HDL and LDL levels were lowered with the increase of the MELD score. Multivariate Cox proportional hazard model showed that MELD ≥18 and TC ≤2.8 mmol/L were independent risk factors for prognosis of decompensated cirrhosis. survival analysis showed that MELD ≥18 combined with TC ≤ 2.8 mmol/L can clearly discriminate between the patients who would survive and die in 1 year. CONCLUSION: MELD ≥18 and TC ≤2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis.

关键词： Cirrhosis Model of end-stage liver disease Blood lipid Prognosis survival time

Prognostic value of post-treatment ^(18)F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy

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Chinese Journal of Cancer Research 2014年第1期26卷 30-37页

作者： Kimiteru Ito Keigo Shimoji Yoko Miyata Kouhei Kamiya Ryogo Minamimoto Kazuo Kubota Momoko Okasaki Miyako Morooka Jyunkichi Yokoyama Department of Radiology National Center of Neurology and Psychiatry Department of Radiology Juntendo University Graduate School of Medicine Division of nuclear Medicine International Medical Center of Global Health Department of Otolaryngology Head and Neck SurgeryJuntendo University Graduate School of Medicine

Objective：To clarify the prognostic value of post-treatment 18F-fluorodeoxyglucose （FDG） positron emission tomography （PET）/computed tomography （CT） in patients with advanced head and neck squamous cell carcinoma （HNSCC） after combined intra-arterial chemotherapy and radiotherapy （IACR）.Methods：Thirty-six patients with HNSCC who underwent IACR were recruited.The period from the end of IACR to the last post-treatment 18F-FDG PET/CT examination was 8-12 weeks.Both patient-based and lesion-based analyses were used to evaluate the PET/CT images.For lesion-based analysis,36 regions （12 lesions of recurrences and 24 scars at primary sites） were selected.The Kaplan-Meier method was used to assess the overall survival （OS） stratified by 18F-FDG uptake or visual interpretation results.Results：Twelve patients with recurrence were identified by six months after IACR.The sensitivity and specificity in the patient-based analysis were 67％（8/12） and 88％（21/24）,respectively.The mean OS was estimated to be 12.1 months （95％ CI,6.3-18.0 months） for the higher maximum standardized uptake value （SUVmax） group （n=7） and 44.6 months （95％ CI,39.9-49.3 months） for the lower SUVmax group （n=29）.OS in the higher SUVmax group （cut-off point,6.1） or positive visual interpretation group was significantly shorter than that in the lower SUVmax or negative visual interpretation group （P＜0.001 and P＜0.05,respectively）.Conclusions：The SUVmax and visual interpretation of HNSCC on post-IACR 18F-FDG PET/CT can provide prognostic survival estimates.

关键词： 18F-fluorodeoxyglucose （18F-FDG） positron emission tomography （PET）/computed tomography （CT） head and neck cancer recurrence survival time intra-arterial chemotherapy and radiotherapy （IACR）