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Trends in the management of anorectal melanoma:A multiinstitutional retrospective study and review of the world literature

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World Journal of Gastroenterology 2021年第3期27卷 267-280页

作者： Josh Bleicher Jessica N Cohan Lyen C Huang William Peche T Bartley Pickron Courtney L Scaife Tawnya L Bowles John R Hyngstrom Elliot A Asare Department of Surgery Huntsman Cancer Institute at the University of UtahSalt Lake CityUT 84114United States Department of Surgery George E Wahlen Department of Veterans Affairs Medical CenterSalt Lake CityUT 84114United States Department of Surgery Intermountain Medical CenterMurrayUT 84107United States

BACKGROUND Anorectal melanoma(ARM)is a rare disease with a poor *** on optimal treatment is limited and surgical management varies *** hypothesized that the frequency of abdominoperineal resection used as primary treatment of ARM has decreased over the past several *** To update our understanding of outcomes for patients with ARM and analyze management trends around the *** This is a multi-institutional,retrospective study of patients treated for ARM at 7 *** included both large,academic,tertiary care centers and smaller,general community *** prospectively maintained institutional tumor registries,we identified 24 patients diagnosed with ARM between January 2000 and May *** analyzed factors prognostic for recurrence and *** then used Cox regression to measure overall survival(OS)and melanoma-specific *** also performed a literature review to assess trends in surgical management and *** Of the 24 patients diagnosed with ARM,12(50.0%)had local,8(33.3%)regional,and 4(16.7%)distant disease at *** time to recurrence was 10.4 mo[interquartile range(IQR)7.5-17.2]with only 2 patients(9.3%)not developing recurrence following surgical *** OS was 18.8 mo(IQR 13.5-33.9).One patient is still alive without recurrence at 21.4 mo from diagnosis;no other patient survived 5 *** surgical management with abdominoperineal resection(APR)vs wide excision(WE)did not lead to differences in OS[hazard ratio=1.4(95%CI:0.3-6.8)].Review of the literature revealed geographic differences in surgical management of ARM,with increased use of WE in the United States and Europe over time and more frequent use of APR in Asia and *** was no significant improvement in survival over *** There is wide variation in the management of ARM and survival outcomes remain poor regardless of *** management should aim to minimize morbidity.

关键词： Melanoma Anorectal melanoma Literature review Melanoma surgery surgical oncology Colorectal surgery

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Giant cellular leiomyoma in the broad ligament of the uterus:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12696-12702页

作者： Jiao Yan Yu Li Xing-Yu Long Dao-Cheng Li Si-Jin Li The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina The Sixth Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Obstetrics and Gynecology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND The treatment of large pelvic masses in postmenopausal women is a challenge in clinical *** ultrasound or magnetic resonance imaging can be used to determine the size and location of the mass,it is still difficult to achieve a preoperative *** majority of cellular leiomyomas are diagnosed by histopathology after *** report the differential diagnosis and surgical management of a rare case of cellular leiomyoma in the broad ligament of the *** SUMMARY A 52-year-old Chinese woman without sexual history was admitted to the First Affiliated Hospital of Guangzhou University of Chinese Medicine for the first *** patient had a 1-year history of progressive abdominal enlargement as well as a 2-year history of menopause,and complained of frequent abdominal pain and low-grade *** tomography of the abdomen showed a solid cystic mass(29.4 cm×18.8 cm×37.7 cm)in the pelvis and ***,routine blood test results indicated a baseline cancer antigen 125(CA-125)level of 187.7 U/mL and C-reactive protein of 109.58 mg/***,retrograde hysterectomy and bilateral adnexectomy were performed in this *** histopathologic examination of the surgical specimen,a rare cellular leiomyoma in the broad ligament was *** Clinicians need to constantly improve diagnosis and treatment for the challenges posed during clinical assessment,differential diagnosis,and surgical management.

关键词： surgical oncology Cellular leiomyoma in the broad ligament Uterine leiomyoma Retrograde abdominal hysterectomy Case report

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Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis

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World Journal of Gastroenterology 2014年第25期20卷 8274-8281页

作者： Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao Department of Surgery and Cancer QEQM BuildingSt Mary’s HospitalImperial CollegeLondon W2 1NY United Kingdom Department of Surgery Hammersmith HospitalImperial College LondonLondon SW7 2AZUnited Kingdom

AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma (HCC) in patients with known liver cirrhosis.

关键词： Laparoscopic Hepatocellular carcinoma Cirrhosis Hepatic resection Surgery Hepatobiliary surgical oncology

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Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma:When and how?

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World Journal of Gastrointestinal oncology 2021年第12期13卷 2050-2063页

作者： Tudor Mocan Adelina Horhat Emil Mois Florin Graur Cristian Tefas Rares Craciun Iuliana Nenu Mihaela Spârchez Zeno Sparchez Third Medical Department "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162Romania Institute for Gastroenterology and Hepatology Cluj-Napoca 400162Romania Second Pediatric Department University of Medicine and Pharmacy"Iuliu Hatieganu"Cluj-Napoca 400162Romania

Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dimprognosis. The role of preoperative and palliative biliary drainage has long beendebated. The most common techniques are endoscopic retrograde cholangiopancreatography(ERCP) and percutaneous transhepatic biliary drainage (PTBD);however, recently developed endoscopic ultrasound-assisted methods are gainingmore atention. Selecting the best available method in any specific scenario iscrucial, yet sometimes challenging. Thus, this review aimed to discuss theavailable techniques, indications, perks, pitfalls, and timing-related issues in themanagement of hCCA. In a preoperative setting, PTBD appears to have someadvantages: low risk of postprocedural complications (namely cholangitis) andbetter priming for surgery. For palliative purposes, we propose ERCP/PTBDdepending on the experience of the operators, but also on other factors: the levelof bilirubin (if very high, rather PTBD), length of the stenosis and the presence ofcholangitis (PTBD), ERCP failure, or altered biliary anatomy.

关键词： Hilar cholangiocarcinoma Endoscopic biliary drainage Percutaneous biliary drainage Endoscopic ultrasound biliary drainage surgical oncology

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Indocyanine green:The guide to safer and more effective surgery

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 641-649页

作者： Pietro Fransvea Maria Michela Chiarello Valeria Fico Maria Cariati Giuseppe Brisinda Emergency Surgery and Trauma Center Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Department of Surgery Azienda Sanitaria Provinciale di CrotoneCrotone 88900Italy Department of Abdominal and Endocrine Metabolic Medical and surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

In this editorial we comment on the article by Kalayarasan and co-workers published in the recent issue of the World Journal of Gastrointestinal *** authors present an interesting review on the use of indocyanine green fluo-rescence in different aspects of abdominal *** also highlight future perspectives of the use of indocyanine green in mini-invasive ***-cyanine green,used for fluorescence imaging,has been approved by the Food and Drug Administration and is safe for use in *** can be administered in-travenously or *** its advent,there have been several advance-ments in the applications of indocyanine green,especially in the surgical field,such as intraoperative mapping and biopsy of sentinel lymph node,measurement of hepatic function prior to resection,in neurosurgical cases to detect vascular anomalies,in cardiovascular cases for patency and assessment of vascular ab-normalities,in predicting healing following amputations,in helping visualization of hepatobiliary anatomy and blood vessels,in reconstructive surgery,to assess flap viability and for the evaluation of tissue perfusion following major trauma and *** these reasons,the intraoperative use of indocyanine green has become common in a variety of surgical specialties and transplant ***-lorectal surgery has just lately begun to adopt this technique,particularly for perfusion visualization to prevent anastomotic *** regular use of in-docyanine green coupled with fluorescence angiography has recently been pro-posed as a feasible tool to help improve patient *** the best available data,it has been shown that routine use of indocyanine green in colorectal surgery reduces the rates of anastomotic *** use of indocyanine green is proven to be safe,feasible,and effective in both elective and emergency ***,additional robust evidence from larger-scale,high-quality studies is essential before incorporating indocyanine g

关键词： Indocyanine green Colorectal surgery Fluorescence-guided surgery Gastrointestinal surgery Hepato-biliary surgery Pancreatic surgery surgical oncology

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Modern surgical approach to hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 953-955页

作者： Paolo Magistri Gian Piero Guerrini Stefano Di Sandro Fabrizio Di Benedetto Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University Hospital of Modena“Policlinico”University of Modena and Reggio EmiliaModenaItaly

We are glad to contribute with an editorial on the important topic of therapeutic opportunities for hepatocellular carcinoma(HCC).The increasing diffusion of minimally invasive approaches to the liver and the growing experience worldwide have progressively changed our curative strategies for patients affected by primary and metastatic liver tumors(1).

关键词： Robotic surgery minimally invasive liver surgery(MILS) surgical oncology liver transplant living donor liver transplantation(LDLT)

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Is it possible to adopt the same oncological approach in urgent surgery for colon cancer?

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World Journal of Clinical oncology 2022年第11期13卷 896-906页

作者： Bruno Yuki Yoshida Raphael L C Araujo José Francisco M Farah Alberto Goldenberg Goldenberg Department of Surgery Federal University of Sao PauloSao Paulo 04024-002Sao PauloBrazil Department of General and Oncological Surgery Sao Paulo State Employee HospitalSao Paulo 04029-000Sao PauloBrazil

BACKGROUND Locoregional complications may occur in up to 30%of patients with colon *** they are frequent events in the natural history of this disease,there should be a concern in offering an oncologically adequate surgical treatment to these *** To compare the oncological radicality of surgery for colon cancer between urgent and elective *** One-hundred and eighty-nine consecutive patients with non-metastatic colon adenocarcinoma were studied over two years in a single institution,who underwent surgical resection as the first therapeutic approach,with 123 elective and 66 urgent *** assessment of oncological radicality was performed by analyzing the extension of the longitudinal margins of resection,the number of resected lymph nodes,and the percentage of surgeries with 12 or more resected lymph *** clinicopathological variables were compared between the two groups in terms of sex,age,tumor location,type of urgency,surgical access,staging,compromised lymph nodes rate,differentiation grade,angiolymphatic and perineural invasion,and early *** There was no difference between the elective and urgency group concerning the longitudinal margin of resection(average of 6.1 in elective vs 7.3 cm in urgency,P=0.144),number of resected lymph nodes(average of 17.7 in elective vs 16.6 in urgency,P=0.355)and percentage of surgeries with 12 or more resected lymph nodes(75.6%in elective vs 77.3%in urgency,P=0.798).It was observed that the percentage of patients aged 80 and over was higher in the urgency group(13.0%in elective vs 25.8%in urgency,P=0.028),and the early mortality was 4.9%in elective vs 15.2%in urgency(P=0.016,OR:3.48,95%CI:1.21–10.06).Tumor location(P=0.004),surgery performed(P=0.016)and surgical access(P<0.001)were also different between the two *** was no difference in other clinicopathological variables *** Oncological radicality of colon cancer surgery may be achieved in both emergency and

关键词： Colorectal cancer Intestinal obstruction Intestinal perforation surgical oncology Lymph node excision

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Role of immunotherapy in gastric cancer with liver metastasis

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World Journal of Clinical oncology 2024年第11期15卷 1383-1389页

作者： Bogdan Gafton Stefan Morarasu Gabriel Dimofte Department of oncology Regional Institute of OncologyIasi 700483Romania Department of oncology Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Second Department of surgical oncology Regional Institute of OncologyFaculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Surgery University of Medicine and Pharmacy Grigore T.Popa IaşiRegional Institute of Oncology IasiIasi 700483Romania

Gastric cancer continues to be a significant issue for public health,marked by its widespread occurrence and high mortality rates,even as the incidence of the disease shows a declining *** liver is the primary site for metastatic spread,with the peritoneum,lungs,and bones also being common *** the advent of biologic treatments and the introduction of immunotherapy for patients with metastatic conditions,the options to treat metastatic gastric cancer have *** diversified therapeutic approach is designed to enhance patient quality of life and prolong survival,showcasing the progress in treatment modalities for individuals with gastric cancer and liver metastases.

关键词： Gastric cancer Immunotherapy Liver metastases Metastatic gastric cancer oncology surgical oncology

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Diagnostic biopsy of cutaneous melanoma, sentinel lymph node biopsy and indications for lymphadenectomy

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World Journal of Clinical oncology 2022年第10期13卷 861-865页

作者： Efstathios T Pavlidis Theodoros E Pavlidis 2^(nd)Prodedeutic Department of Surgery Hippocration HospitalAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece

The incidence of cutaneous melanoma appears to be increasing worldwide and this is attributed to solar radiation *** diagnosis is a challenging *** clinically suspected lesion must be assessed by complete diagnostic excision biopsy(margins 1-2 mm);however,there are other biopsy techniques that are less commonly *** are characterized by Breslow thickness as thin(4 mm).This thickness determines their biological behavior,therapy,prognosis and *** the biopsy is positive,a wide local excision(margins 1-2 cm)is finally ***,metastasis to regional lymph nodes is the most accurate prognostic ***,sentinel lymph node biopsy(SLNB)for diagnosed melanoma plays a pivotal role in the management *** lymph node clearance has undoubted advantages and is recommended in all cases of positive SLN biopsy.A PET-CT(positron emission tomography-computed tomography)scan is necessary for staging and follow-up after *** targeted therapies and immunotherapies have shown improved outcomes in advanced cases.

关键词： surgical oncology Malignant melanoma Skin cancer Cutaneous melanoma Sentinel lymph node biopsy Complete lymph node dissection

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