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Infra-tentorial brain tumor subtypes in children and adults--surgical outcome in an ethnic population with a single regional tertiary center

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Chinese Neurosurgical Journal 2022年第3期8卷 160-168页

作者： Abdul Rashid Bhat Muhammed Afzal Wani Altaf Rehman Kirmani Department of Neurosurgery Sher-i-Kashmir Institute of Medical Sciences(SKIMS)SrinagarKashmirIndia

Background:To analyze clinically and radiologically the surgical outcome like residual disease,progression of disease,recurrence,disabilities,event-free survival(EFS),and mortality of different infra-tentorial tumor subtypes in children and adults of a strictly non-migratory and ethnic ***:The 410 histologically proved,out of 589,infra-tentorial brain tumor patients were analyzed clinically and by the imaging post-surgically in a single tertiary center for an ethnic *** this analytico-observational study,retrospectively postoperative records of 589 infra-tentorial brain tumors from November 1998 to December 2018(20 years)were retrieved,scrutinized,and *** post-operative clinic-radiological records of 410 patients with proved histopathological examination results were *** law of variance was applied where-ever ***:The 63.2%of the all 410 operated infra-tentorial brain tumors were males while females predominated in meningiomas and *** 31.7%infra-tentorial tumors were children(below 18 years).About 54.1%cases were histologically *** residual tumors comprised 40.2%and symptoms of disease-progression occurred in 10.9%.The tumor recurrence occurred in 14.3%while 6.0%patients developed severe *** overall mortality was 11.4%but 18.9%in malignant *** event-free survival(EFS)for all the patients was 66.0%,patients with malignancies had 47.7%and benign group had 87.7%.Conclusion:The study,surgical outcome of infra-tentorial brain tumor subtypes in children and adults(approx.1/3rd of patients being children),conducted in a tertiary center at a remote land-locked location with non-migratory ethnic population as its catchment area,has a significant epidemiological value for the community and the region.

关键词： Infra-tentorial brain tumors Histological subtypes Ethnic population surgical outcome

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surgical outcome and patient satisfaction after Z-epicanthoplasty and blepharoplasty

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1922-1925页

作者： Jing-Yi Zhao Xiao-Shuang Guo Guo-Dong Song Xian-Lei Zong Xiao-Nan Yang Le Du Chen-Zhi Lai Zuo-Liang Qi Xiao-Lei Jin Department No.16 Plastic Surgery Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

AIM: To evaluate surgical outcomes of modified Z-epicanthoplasty with blepharoplasty that we previously reported from the patient’s perspective using patient-reported outcome measures(PROMs) and patient satisfaction ***: A total of patients(n=180) who underwent the surgery between January 2013 and June 2016 were randomly selected. Standardized patient satisfaction forms(total score, 40) and validated PROMs questionnaires(total score, 12) were sent to patients for completion. PROMs assesses the severity of scarring, pain and asymmetry, as well as functional and appearance ***: All patients were female, ranging from 18 to 35 years old(mean=24). The response rate was 73.3%(n=132). The majority of patients reported good or excellent outcomes based on PROM analysis. Patients reported minimum or non-visible scarring at both the double eyelid surgical scar(85.6%) and the inner canthus(80.3%). Issues concerning function and appearance were minimal as 80.3% reported satisfaction with both domains. Notably, the majority of patients reported either a high or very high satisfaction rate to yield a mean score of 104 out of 120(Poutcomes based on PROM results, which shows a positive linear relationship with patient satisfaction scores.

关键词： surgical outcome patient satisfaction patient-reported outcome measures Z-epicanthoplasty blepharoplasty

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Predisposing factors and surgical outcome of complicated liver hydatid cysts

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World Journal of Gastroenterology 2010年第24期16卷 3040-3048页

作者： Alper Akcan Erdogan Sozuer Hizir Akyildiz Zeki Yilmaz Ahmet Ozturk Altay Atalay Department of General Surgery Erciyes University School of Medicine Department of Biostatistics Erciyes University School of Medicine Department of Microbiology Erciyes University School of Medicine

AIM: To evaluate the predisposing factors for peritoneal perforation and intrabiliary rupture and the effects of these complications on surgical outcome in liver hydatid ***: A total of 372 patients with liver hydatid cysts who had undergone surgical treatment were evaluated retrospectively. Twenty eight patients with peritoneal perforation, 93 patients with spontaneous intrabiliary perforation, and 251 patients with noncomplicated hydatid cysts were treated in our ***: When the predisposing factors for complications were evaluated, younger age, superf icial position, and larger cyst dimensions (P surgical procedure in all groups (71.6%). The incidence of postoperative complications in the peritoneal perforated group, in the intrabiliary ruptured group, and in the noncomplicated group was 25%, 16.1% and 5.5%, respectively. When compared, complication rates were significantly different (P = 0.002). When length of hospital stay was compared, there was no signif icant difference between the groups (P > 0.05). The overall recurrence rate was 3.8% (14 patients), but there was not any statistical difference among the patient groups (P = 0.13). The early postoperative mortality rate was 1.1%. CONCLUSION: In peritoneally perforated and intrabiliary ruptured cases, the most important steps are irrigation of the peritoneal cavity and clearance of the cystic material from the biliary tree.

关键词： Complicated liver hydatid cysts Predisposing factors surgical treatment surgical outcome

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Comparison of surgical outcome of trabeculectomy and phacotrabeculectomy in Chinese glaucoma patients

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1928-1930页

作者： Bonnie Nga Kwan Choy Department of Ophthalmology LKS Faculty of Medicinethe University of Hong KongHong KongChina

Our study retrospectively reviewed the surgical outcomes up to 3 mo of 38 consecutive Chinese glaucoma patients who underwent trabeculectomy（n=18） or phacotrabeculectomy（n=20）.Baseline age,visual acuity,and intraocular pressure were *** pressure from post-operative 1 d to 3 mo were similar between 2 *** success was achieved in 65% of phacotrabeculectomy,and 66.7% of trabeculectomy cases;while failure occurred in 16.7% of phacotrabeculectomy,and 10% of trabeculectomy cases at 3 *** group consistently showed better improvement in visual *** blebs occurred in 65% of phacotrabeculectomy and 83% of trabeculectomy eyes;and flat blebs in 35% of phacotrabeculectomy,but none after *** was more hypotony（5% vs 0） after *** conclude,phacotrabeculectomy and trabeculectomy demonstrated comparable intraocular pressure control up to 3 mo ***,phacotrabeculectomy patients had better visual acuity ***,more diffuse bleb and less hypotony were present following trabeculectomy.

关键词： trabeculectomy phacotrabeculectomy glaucoma surgery surgical outcome

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A Modified Enhanced Recovery after Surgery (ERAS): Use and surgical outcome in Breast Cancer Patients

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Journal of Biosciences and Medicines 2018年第3期6卷 15-25页

作者： Tajudeen A.Wahab Hanna Uwakwe Maher Jumah Rilwan Aransi Humayun Kabir Khan Elm Breast Care Centre BarkingHavering and Redbridge University Hospitals NHS TrustKing George HospitalLondonUK

Background: ERAS protocols are perioperative interventions aimed at reducing postoperative complications, length of hospital stay (LOS) and early return to normal activities. This has improved outcome in many surgical specialties, including breast surgery. We present the surgical outcome of breast cancer (BC) patients treated over a 12-month period following the principle of ERAS protocols and highlight the underpinning evidence. Methods: A retrospective analysis of all BC patients diagnosed and had breast cancer surgery over 12 months. Data collected included patient’s demographics, type of surgery, LOS, other perioperative care and significant postoperative complications. Excluded were patients with bilateral cancer surgeries, diagnostic excision, margin clearance or breast reconstruction. Results: There were 621 BC diagnosed including 5 male and 12 bilateral female BC. The ages ranged from 25 to 93 years. Excluding bilateral BC, 351 patients (70.2 %) had breast conserving surgery (BCS) while 149 (29.8%) patients had mastectomy as index cancer surgery. Sixteen (4.5%) of the women who initially underwent BCS subsequently had a completion mastectomy. The overall rate of successful BCS was 335/500 (67%). 441 (85.5%) of patients were discharged same or next day. 12 (7.2%) cases of postoperative haematoma, 6 cases of wound infection and a case of seroma requiring surgical/radiological drainage recorded. Conclusion: ERAS protocol in BC surgery is associated with decreased LOS and low complication rate. Delayed discharges are mostly due to adverse social factors and medical comorbidity rather than post-operative surgical complications.

关键词： ERAS^(■) Breast Cancer surgical outcome

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Pathological and Physiological High-frequency Oscillations on Electroencephalography in Patients with Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 609-620页

作者： Hongyi Ye Cong Chen Shennan A.Weiss Shuang Wang Department of Neurology Epilepsy CenterSecond Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China Department of Neurology State University of New York DownstateBrooklynNY11203USA Department of Physiology and Pharmacology State University of New York DownstateBrooklynNY11203USA Department of Neurology New York City Health+Hospitals/Kings CountyBrooklynNY11203USA

High-frequency oscillations(HFOs)encompass ripples(80 Hz–200 Hz)and fast ripples(200 Hz–600 Hz),serving as a promising biomarker for localizing the epileptogenic zone in *** fast ripples are always pathological,while ripples may be physiological or *** physiological from pathological ripples is important not only for designating epileptogenic brain regions,but also for investigations that study ripples in the context of memory encoding,consolidation,and recall in patients with *** studies have sought to identify distinguishing features between pathological and physiological ripples over the past two *** and pathological ripples differ with respect to their spatial location,cellular mechanisms,morphology,and coupling with background electroencephalographic *** studies have demonstrated that differentiating between pathological and physiological ripples can improve surgical outcome *** this review,we summarize the characteristics,differences,and applications of pathological and physiological HFOs and discuss strategies for their clinical translation.

关键词： Ripples Epilepsy Memory Sleep surgical outcome

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Clinical Characteristics, Imaging Findings and surgical outcomes of Chiari Malformation Type I in Pediatric and Adult Patients

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Current Medical Science 2018年第2期38卷 289-295页

作者： Zhuo-wei LEI Shi-qiang WU Zhuo ZHANG Yang HAN Jun-wen WANG Feng LI Kai SHU Department of Orthopedics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

A growing number of children and adolescents are being diagnosed as Chiari malformation type I （CM- I ） for behavioral disorders, developmental delay, seizures, or abnormal orpharyngeal function. The aim of this study was to compare the clinical characteristics, imaging findings and surgical outcomes of CM- I in pediatric and adult patients. Between January 2014 and June 2017, 84 patients with CM- I underwent surgical treatment in our department. We divided the patients into two groups： pediatric group （n=l 1, age 〈18 years） and adult group （n=73, age 〉18 years）. Data on clinical characteristics, imaging findings, surgical outcomes, and prognosis were retrospectively reviewed and compared between these two groups. For clinical presentation, scoliosis （36.4%） and developmental delay （36.4%） were more common in pediatric patients, whereas, sensory disturbance （58.9%） and motor weakness （41. 1%） were more common in adult patients. Imaging findings showed that the incidence of hydrocephalus and craniovertebral junctional abnormalities was significantly higher in pediatric group than in adult group （P〈0.05）. Compared to adult group, pediatric group showed a better improvement or resolution of syrinx and tonsillar herniation after surgical treatments （P〈0.05）. The total Chicago Chiari outcome Scale （CCOS） score in pediatric patients at the last follow- up was significantly higher than that in adult patients （P=0.002）. In conclusion, the clinical characteristics and imaging findings appeared to be different in pediatric and adult patients with CM- I. The surgical outcomes of pediatric patients were shown to be significantly better than those of adult patients.

关键词： Chiari malformation type I adult patients pediatric patients clinical manifestations surgical outcome

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Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma

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World Journal of Hepatology 2017年第35期9卷 1286-1295页

作者： Hiroki Koga Keita Kai Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro Department of Surgery Saga University Faculty of Medicine Department of Pathology Saga University Hospital Department of Pathology and Microbiology Saga University Faculty of Medicine Center for Comprehensive Community Medicine Saga University Faculty of Medicine

AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical *** Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors.

关键词： Hepatocellular carcinoma Non-B non-C Occult hepatitis B virus infection Surgery surgical outcome

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Deep sclerectomy-trabeculectomy with mitomycin C in treating glaucoma:postoperative long-term results

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1951-1959页

作者： Chung Shen Chean Li Jiang Gayathri Kanchana Niroshani Pati Arambage Punithawathy Ranjit Ophthalmology Department Royal Stoke University HospitalNewcastle RoadStoke-on-Trent ST46QGUnited Kingdom

AIM:To determine the long-term postoperative outcomes of deep sclerectomy-trabeculectomy(DST)with mitomycin C(MMC)in the treatment of ***:Patients who underwent DST with MMC between 2010 and 2017 were included in this retrospective observational *** success was defined as postoperative intraocular pressure(IOP)≤21 mm Hg or 30%reduction of IOP from baseline without any topical IOP-lowering agent,and qualified success defined as IOP≤21 mm Hg or 30%reduction of IOP from baseline with/without single topical *** evaluated the surgical success rates and complication rates of this procedure,as well as described the IOP profiles,best corrected visual acuity(BCVA)profiles and mean deviations(MD)of Humphrey visual field(HVF)24-2 performance at each follow-up time *** linear regression models were constructed to determine estimated predictive values of demographic data,use of topical IOPlowering agents,baseline and postoperative IOP and optical profiles(e.g.,BCVA and MD).RESULTS:Totally 98 eyes(mean postoperative followup 67.5mo)showed mean IOP reduction at every followup *** median BCVA and MD of visual fields were maintained throughout the follow-up intervals when comparing to *** number of IOP-lowering medications decreased from 2.8±0.8 to 0.3±0.7(P=0.068).Totally 84(85.7%)eyes achieved complete success at final *** hyphaema and transient choroidal effusion developed in 15 eyes(15.3%)and 11 eyes(11.2%)*** complications included shallow anterior chamber in 5 eyes(5.1%),bleb leak in 4 eyes(4.1%),bleb revision in 7 eyes(7.1%),bleb needling in 9 eyes(9.2%)and repeat trabeculectomy in 1 eye(1.0%).There was no endophthalmitis,blebitis or macular *** was no significant correlation between postoperative IOP control and postoperative ***:DST with MMC demonstrates effective and sustained long-term outcomes in the treatment of glaucoma with no major complication.

关键词： glaucoma surgical outcome deep sclerectomy trabeculectomy mitomycin C

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World Journal of Gastroenterology 2010年第40期16卷 5024-5034页

作者： Konstantin Umanskiy Alessandro Fichera Department of Surgery University of Chicago Medical Center

Over the past 30 years, health related quality of life (HRQOL) has developed into a scientific index of subjective health status. Measurement of HRQOL is now clearly a mandatory component in evaluating interventions and management of medical and surgical diseases. In designing comprehensive and meaningful clinical studies particular attention ought to be made of measures of HRQOL. This is clearly very important in inflammatory bowel disease. Both ulcerative colitis (UC) and Crohn’s disease (CD) have a major impact on HRQOL. The chronic and unrelenting nature of these diseases, the often early age of onset, and the impact on social and sexual aspects of life significantly change patient’s perception, body image and quality of life. This manuscript is an overview of the available published data on HRQOL in UC and CD patients focusing on the impact of surgical therapy. While these two diseases may have some similarities in their management, clearly their impact on quality of life and the effects of are significantly different. Hence we are presenting the data separately.

关键词： Inflammatory bowel disease Quality of life Gastrointestinal surgery surgical outcome

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