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Aggregate 2024年第5期5卷 454-464页

作者： Manyu Zhu Shanshan Li Qixin Liu Yuqi Zhang Zihao Li Yiran Wang Lie Wu Xiue Jiang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiChina Research Center for Analytical Science College of ChemistryNankai UniversityTianjinChina

surface chirality plays an important role in determining the biological effect,but the molecular nature beyond stereoselectivity is still ***,through surface-enhanced infrared absorption spectroscopy,electrochemistry,and theoretical simulations,we found diasteromeric monolayers induced by assembled density on chiral gold nanoﬁlm and identiﬁed the positive contribution of water dipole poten-tial at chiral interface and their different interfacial interactions,which result in a difference both in the positive dipoles of interfacial water compensating the negative surface potential of the SAM and in the hindrance effect of interface dehydration,thereby regulating the interaction between amyloid-βpeptide(Aβ)and N-isobutyryl-cysteine(NIBC).Water on L-NIBC interface which shows stronger positive dipole potential weakens the negative surface potential,but its local weak binding to the isopropyl group facilitates hydrophobic interaction between Aβ42 and L-NIBC and resultedﬁber ***,electrostatic interaction between Aβ42 and D-NIBC induces spherical ***ﬁndings provide new insight into molecular nature of chirality-regulated biological effect.

关键词： amyloid-β42 chiral interface surface-enhanced infrared absorption spectroscopy

Attenuated Total Reflection surface-enhanced infrared absorption spectroscopy: a Powerful Technique for Bioanalysis

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Journal of Analysis and Testing 2017年第1期1卷 71-83页

作者： Jian Li Bo Zheng Qian-Wen Zhang Yang Liu Cai-Feng Shi Feng-Bin Wang Kang Wang Xing-Hua Xia State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China

Attenuated total reflection surface-enhanced infrared absorption spectroscopy(ATR-SEIRAS)has recently been proven to be a powerful tool for *** enables in situ and in real-time observation of dynamic processes occurring on specific interface,revealing rich structural and functional information of biomolecules at sub monolayer *** aim of this general review was to give an overview of the cutting edge applications of *** start with description of the basic configuration of the standard ATR-SEIRAS *** enhanced mechanisms and methods to fabricate enhanced substrates are then *** discuss the recent developments,challenges and applications of ATR-SEIRAS in bioanalysis,mainly focusing on DNA analysis,protein behavior and cell ***,further development of the ATRSEIRAS technique with enhanced sensitivity,improved time and spatial resolutions will be prospected.

关键词： surface-enhanced infrared absorption spectroscopy ATR-SEIRAS Bioanalysis DNA Protein Cell

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

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Light(Science & Applications) 2017年第1期6卷 656-665页

作者： Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug Bionanophotonic Systems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne CH-1015Switzerland Laboratory of Molecular Neurobiology and Neuroproteomics EPFLLausanne CH-1015Switzerland Institute of Physics Laboratory of the Physics of Living MatterEPFLLausanne CH-1015Switzerland Department of Chemistry Lensfield roadUniversity of CambridgeCambridge CB21EWUK

Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant *** amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and ***,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I *** successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative ***,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological *** nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers.

关键词： label-free biosensing nanoantennas plasmonics protein secondary structure surface-enhanced infrared absorption spectroscopy

Boron nitride nanoresonators for phonon-enhanced molecular vibrational spectroscopy at the strong coupling limit

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Light(Science & Applications) 2017年第1期6卷 55-62页

作者： Marta Autore Peining Li Irene Dolado Francisco J Alfaro-Mozaz Ruben Esteban Ainhoa Atxabal Fèlix Casanova Luis E Hueso Pablo Alonso-González Javier Aizpurua Alexey Y Nikitin Saül Vélez Rainer Hillenbrand CIC nanoGUNE Donostia-San Sebastián 20018Spain Donostia International Physics Center(DIPC) Donostia-San Sebastián 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain Departamento de Física Universidad de OviedoOviedo 33007Spain Centro de Física de Materiales(MPC CSIC-UPV/EHU)Donostia-San Sebastián 20018Spain Current address:Department of Materials ETH ZürichZürich 8093Switzerland CIC nanoGUNE and UPV/EHU Donostia-San Sebastián 20018Spain

enhanced light-matter interactions are the basis of surface-enhanced infrared absorption(SEIRA)spectroscopy,and conventionally rely on plasmonic materials and their capability to focus light to nanoscale spot *** polariton nanoresonators made of polar crystals could represent an interesting alternative,since they exhibit large quality factors,which go far beyond those of their plasmonic *** recent emergence of van der Waals crystals enables the fabrication of highquality nanophotonic resonators based on phonon polaritons,as reported for the prototypical infrared-phononic material hexagonal boron nitride(h-BN).In this work we use,for the first time,phonon-polariton-resonant h-BN ribbons for SEIRA spectroscopy of small amounts of organic molecules in Fourier transform infrared ***,the interaction between phonon polaritons and molecular vibrations reaches experimentally the onset of the strong coupling regime,while numerical simulations predict that vibrational strong coupling can be fully *** polariton nanoresonators thus could become a viable platform for sensing,local control of chemical reactivity and infrared quantum cavity optics experiments.

关键词： boron nitride phonon polaritons strong coupling surface-enhanced infrared absorption spectroscopy SEIRA