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surface functionalization OF POLYSTYRENE TO BIND WITH FMRF PEPTIDES FOR NOVEL BIOCOMPATIBILITY

Chinese Journal of Polymer Science 2010年第6期28卷 895-902页

作者： Yong Chen Hong-sheng Lu Peng Wang Department of Applied Chemistry School of Chemical & Environmental Engineering Shandong University of Science and Technology Qingdao 266510 China Department of Environmental Science and Technology School of Chemical & Environmental Engineering Shandong University of Science and Technology Qingdao 266510 China

A generic method was described to change surface biocompatibihty by introducing reactive functional groups onto surfaces of polymeric substrates and covalently binding them with biomolecules.A block copolymer with protected carboxylic acid functionality,poly（styrene-b-tert-butyl acrylate）（PS-PtBA）,was spin coated from solutions in toluene on a bioinert polystyrene（PS） substrate to form a bilayer structure：a surface layer of the poly（tert-butyl acrylate）（PtBA） blocks that order at the air-polymer interface and a bottom layer of the PS blocks that entangle with the PS *** thickness of the PtBA layer and the area density of tert-butyl ester groups of PtBA increased linearly with the concentration of the spin coating solution until a 2 nm saturated monolayer coverage of PtBA was achieved at the concentration of 0.4%W/*** protected carboxylic acid groups were generated by exposing the tert-butyl ester groups of PtBA to trifluoroacetic acid （TFA） for bioconjugation with FMRF peptides via amide *** yield of the bioconjugation reaction for the saturated surface was calculated to be 37.1%based on X-ray photoelectron spectroscopy（XPS） *** success of each functionalization step was demonstrated and characterized by XPS and contact angle *** polymer functionalization/modification concept can be virtually applied to any polymeric substrate by choosing appropriate functional block copolymers and biomolecules to attain novel biocompatibility.

关键词： surface functionalization Biocompatibility Bioconjugation reaction

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surface functionalization of SPR chip for specific molecular interaction analysis under flow condition

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Journal of Innovative Optical Health Sciences 2017年第2期10卷 30-39页

作者： Tao Ma Xiaoxia Chen Qing Peng Pengfei Zhang Yonghong He Department of Ophthalmology Shanxi Eye Hospital Taiyuan 030002P.R.China Department of Ophthalmology Xin Hua hospital affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 P.R.China Department of Ophthalmology MinHang Hospital Affiliated to Fudan University Shanghai 201199P.R.China Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Institute of optical imaging and sensing Graduate School at Shenzhen Tsinghua University Shenzhen 518055P.R.China Department of Physics Tsinghua University Beijing 100084P.R.China

surface functionalization of sensor chip for probe immobilization is crucial for the biosensing applications of surface plasmon resonance(SPR)*** this paper,we report a method circulating the dopamine aqueous solution to coat polydopamine film on sensing surface for surface functionalization of SPR *** polydopamine film with available thickness can be easily prepared by controlling the circulation time and the biorecognition elements can be immobilized on the polydopamine film for specific molecular interaction *** opera-tions are all performed under flow condition in the fuidic system,and have the advantages of easy implementation,less time consuming,and low cost,because the reagents and devices used in the operations are routinely applied in most *** this study,the specific absorption between the protein A probe immobilized on the sensing surface and human immunoglobulin G in the buffer is monitored based on this surface functionalization strategy to demonstrated its feasibility for SPR biosensing applications.

关键词： surface plasmon resonance surface functionalization dopamine molecular interac-tion analysis

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surface functionalization of PEO Nanofibers Using a TiO_(2) Suspension as Sheath Fluid in a Modified Coaxial Electrospinning Process

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Chemical Research in Chinese Universities 2021年第3期37卷 571-577页

作者： ZHENG Gaofeng PENG Hao JIANG Jiaxin KANG Guoyi LIU Juan ZHENG Jianyi LIU Yifang Department of Instrumental and Electrical Engineering Xiamen UniversityXiamen361102P.R.China Fujian Innovation Center of Additive Manufacturing Fuzhou350118P.R.China

Convenient and integration fabrication process is a key issue for the application of functional nanofibers.A surface functionalization method was developed based on coaxial electrospinning to produce ultraviolet(UV)protection *** titanium dioxide(TiO_(2))nanoparticles suspension was delivered through the shell channel of the coaxial spinneret,by which the aggregation of TiO_(2) nanoparticles was overcome and the distribution uniformity on the surface of polyethylene oxide(PEO)nanofiber was *** the content of TiO_(2) increasing from 0 to 3%(mass fraction),the average diameter of nanofibers increased from(380±30)nm to(480±100)*** surface functionalization can be realized during the electrospinning process to gain PEO/TiO_(2) composite nanofibers *** uniform distribution of TiO_(2) nanoparticles on the surface of nanofibers enhanced the UV absorption and resistance *** maximum UV protection factor(UPF)value of composite nanofibers reaches *** work presented a novel surface-functionalized way for the preparation of composite nanofiber,which has great application potential in the field of micro/nano system integration fabrication.

关键词： Coaxial electrospinning surface functionalization TiO_(2)nanoparticle Composite nanofiber UV protection

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Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

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Friction 2023年第7期11卷 1194-1211页

作者： Xiaowei MAO Kexin CHEN Yanlong ZHAO Chunrong Xiong Jing LUO Yuguang WANG Bo WANG Hongyu ZHANG School of Chemical Engineering and Technology Hainan UniversityHaikou 570228China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Peking University School of Nursing&National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100191China Beijing Research Institute of Automation for Machinery Industry Co. Ltd.Beijing 100120China Center of Digital Dentistry Peking University School and Hospital of Stomatology&NHC Research Center of Engineering and Technology for Computerized DentistryBeijing 100081China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China

Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage *** the present study,bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages,a biomimetic self-adhesive dopamine methacrylamide-poly(2-methacryloyloxyethyl phosphorylcholine)(DMA-MPC)copolymer was designed and synthesized via free radical *** copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles(bMSNs)by the dip-coating method to prepare the dual-functional nanoparticles(bMSNs@DMA-MPC),which were evaluated using a series of surface characterizations including the transmission electron microscope(TEM),Fourier transform infrared(FTIR)spectrum,thermogravimetric analysis(TGA),X-ray photoelectron spectroscopy(XPS),*** tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug,i.e.,diclofenac sodium(DS).In addition,the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 ***,the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β(IL-1β)and interleukin-6(IL-6).In summary,the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

关键词： surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis

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surface functionalization of Microporous Polypropylene Membrane with Polyols for Removal of Boron Acid from Aqueous Solution

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Chinese Journal of Chemical Engineering 2014年第1期22卷 11-18页

作者：周蓉狄玲王苍方艳吴健徐志康 MOE Key Laboratory of Macromolecular Synthesis and functionalization Department of Polymer Science and Engineering Zhejiang University Department of Chemistry Zhejiang University

Affinity membranes are fabricated for boric acid removal by the surface functionalization of microporous polypropylene membrane(MPPM)with lactose-based *** affinity is based on specific complexation between boric acid and saccharide polyols.A photoinduced grafting-chemical reaction sequence was used to prepare these affinity ***(2-aminoethyl methacrylate hydrochloride)[poly(AEMA)]was grafted on the surfaces of MPPM by UV-induced graft *** in the membrane pores was visualized by dying the cross-section of poly(AEMA)-grafted MPPM with fluorescein disodium and imaging with confocal laser scanning *** is concluded that lactose ligands can be covalently immobilized on the external surface and in the pores by the subsequent coupling of poly(AEMA)with lactobionic acid(LA).Physical and chemical properties of the affinity membranes were characterized by field emission scanning electron microscopy and Fourier Transform Infrared/Attenuated Total Refraction spectroscopy(FT-IR/ATR).3-Aminophenyl boric acid(3-APBA)was removed from aqueous solution by a single piece of lactose-functionalized MPPM in a dynamic filtration *** results show that the 3-APBA removal reaches an optimal efficiency(39.5%)under the alkaline condition(pH9.1),which can be improved by increasing the immobilization density of *** of these affinity membranes can be easily realized through acid-base washing because the complexation of boric acid and saccharide polyol is reversible.

关键词： surface functionalization affinity membrane microporous polypropylene membrane boron removal polyols

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Plenty more room on the glass bottom： surface functionalization and nanobiotechnology for cell isolation

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Nano Research 2018年第10期11卷 5107-5129页

作者： Ali Ansari P. I. Imoukhuede Bioengineering Department University of Illinois at Urbana-Champaign Urbana IL 61B01 USA Biomedical Engineering Department Washington University in St. Louis St. Louis MO 63130 USA

surface functionalization is a widely adopted technique for surface modification which allows researchers to customize surfaces to integrate with their research. surface functionalization has been used recently to adapt surfaces to integrate with biological materials specifically to isolate cells or mimic biological tissues through cell patterning. Cell isolation and cell patterning both can be integrated with extant techniques or surfaces to customize the research to whatever needs to be tested. Substrates such as metals, biologically mimicking surfaces, environmental responsive surfaces, and even three-dimensional surfaces such as hydrogels have all been adapted to allow for functionalization for both patterning and isolation. In this review we have described both the advantages and disadvantages of these techniques and the related chemistries to better understand these tools and how best to apply them in the hope that we can further expand upon the research in the field.

关键词： surface functionalization cell isolation cell patterning self-assembled monolayers hyclrogels surface modification

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The role of surface functionalization of silica nanoparticles for bioimaging

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Journal of Innovative Optical Health Sciences 2016年第4期9卷 11-26页

作者： Maria C.Gomes Angela Cunha Tito Trindade João P.C.Tome QOPNA University of Aveiro 3810-193 AveiroPortugal CICECO and Department of Chemistry University of Aveiro 3810-193 AveiroPortugal CESAM and Department of Biology University of Aveiro 3810-193 AveiroPortugal Centro de Quimica Estrutural Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal Department of Organic and Macromolecular Chemistry Ghent University B-9000 Gent Belgium

Among the several types of inorganic nanoparticles available,silica nanoparticles(SNP)have earned their relevance in biological applications namely,as bioimaging *** fact,uorescent SNP(FSNP)have been explored in this-eld as protective nanocarriers,overcoming some limitations presented by conventional organic dyes such as high photobleaching rates.A crucial aspect on the use of uorescent SNP relates to their surface properties,since it determines the extent of interaction between nanoparticles and biological systems,namely in terms of colloidal stability in water,cellular recognition and internalization,tracking,biodistribution and speci-city,among ***,it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces,making surface functionalization a relevant step in order to take full advantage of particle *** versatility of the surface chemistry on silica platforms,together with the intrinsic hydrophilicity and biocompatibility,make these systems suitable for bioimaging applications,such as those mentioned in this review.

关键词： Fluorescent silica nanoparticles bioimaging surface functionalization nanoparticlecell interactions.

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Double-sided surface functionalization: An effective approach to stabilize and modulate the electronic structure of graphene-like borophene

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InfoMat 2021年第3期3卷 327-336页

作者： Xiao Tang Jinxing Gu Jing Shang Zhongfang Chen Liangzhi Kou School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbaneQueenslandAustralia Department of Chemistry University of Puerto RicoRio Piedras CampusSan JuanPuerto Rico

Graphene-like borophene was theoretically proposed and recently synthesized on Al(111)surface,however,how to conquer its structural instability is still an open *** means of density functional theory computations,we theoretically predicted that honeycomb borophene can be well stabilized by double-sided surface passivation with monovalent functional groups(X=F,Cl,Br,I,OH,and NH2)due to the electron *** system undergoes the transition from metallic to semiconducting upon functionalization,while the energy gap depends on the choice of functional *** external strain,the gap values can be manipulated over a broad *** further calculations indicated that the functionalized borophene possesses moderate and anisotropic carrier mobility,which is comparable to or even higher than some 2D materials such as MoS2 and *** work provides a feasible strategy to effectively stabilize the graphene-like borophene and tune the electronic properties with great potentials for electronic applications.

关键词： density functional theory calculations graphene-like borophene surface functionalization twodimensional materials

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Thermally Conductive and Insulating Epoxy Composites by Synchronously Incorporating Si-sol Functionalized Glass Fibers and Boron Nitride Fillers

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Chinese Journal of Polymer Science 2020年第7期38卷 730-739,I0006页

作者： Rui-Han Zhang Xue-Tao Shi Lin Tang Zheng Liu Jun-Liang Zhang Yong-Qiang Guo Jun-Wei Gu Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

Glass fibers(GFs)/epoxy laminated composites always present weak interlaminar shear strength(ILSS)and low cross-plane thermal conductivity coefficient(λ⊥).In this work,silica-sol,synthesized from tetraethyl orthosilicate(TEOS)and KH-560 via sol-gel method,was employed to functionalize the surface of GFs(Si-GFs).Together with a spherical boron nitride(BNN-30),the thermally conductive BNN-30/Si-GFs/epoxy laminated composites were then *** demonstrate that Si-sol is beneficial to the improvement of mechanical properties for epoxy laminated composites(especially for ILSS).The BNN-30/Si-GFs/epoxy laminated composites with 15 wt%BNN-30 fillers display the optimal comprehensive ***-planeλ(λ//)andλ⊥reach the maximum of 2.37 and 1.07 W.m-1.K-1,146.9%and 132.6%higher than those of SiGFs/epoxy laminated composites(λ//=0.96 W.m-1.K-1 andλ⊥=0.46 W.m-1K-1),respectively,and also about 10.8 and 4.9 times those of pure epoxy resin(λ//=λ⊥,0.22 W.m-1.K-1).And the heat-resistance index(THRI),dielectric constant(ε),dielectric loss(tanδ),breakdown strength(E0),surface resistivity(ρs)as well as volume resistivity(ρv)are 197.3℃,4.95,0.0046,22.3 ***-1,1.8×1014Ω,and 2.1×1014Ω.cm,respectively.

关键词： Thermally conductive composites Glass fibers Epoxy resin Silica-sol surface functionalization

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Chemical design and characterization of cellulosic derivatives containing high-nitrogen functional groups:Towards the next generation of energetic biopolymers

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Defence Technology（防务技术） 2022年第4期18卷 537-546页

作者： Ahmed Fouzi Tarchoun Djalal Trache Thomas M.Klapotke Amir Abdelaziz Mehdi Derradji Slimane Bekhouche Energetic Materials Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria Energetic Propulsion Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria Department of Chemistry Ludwig Maximilian University Butenandtstrasse 5-13(D)D-81377MunichGermany Process Engineering Laboratory Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17Bordj El-Bahri16046AlgiersAlgeria

In this research,a promising class of insensitive and high-energy dense biopolymers,which contain nitrogen-rich 1H-tetrazol-1-yl acetate and nitrate ester functional groups,was successfully synthesized through tetrazole derivatization and nitration of cellulose and its micro-sized derivative(TNCN and TCMCN).Their molecular structures,physicochemical properties,thermal behaviors,mechanical sensitivities and detonation performances were studied and compared to those of the corresponding nitrocellulose and nitrated micro-sized cellulose(NCN and CMCN).The developed energetic TNCN and TCMCN exhibited insensitive character with excellent features such as density of 1.710 g/cm3and 1.726 g/cm3,nitrogen content of 20.95%and 22.59%,and detonation velocity of 7552 m/s and 7786 m/s,respectively,and thereby demonstrate their potential applications as new generation of energetic biopolymers to substitute the common ***,thermal results showed that the designed nitrated and chemical modified cellulosic biopolymers displayed good thermal stability with multistep decomposition *** results enrich future prospects for the design of promising insensitive and high-energy dense cellulose-rich materials and commence a new chapter in this field.

关键词： Cellulose surface functionalization Tetrazole Nitrate ester Nitrogen-rich polymer Energetic properties

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