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Panhypopituitarism caused by a suprasellar germinoma: A case report

World Journal of Clinical Cases 2024年第10期12卷 1844-1850页

作者： Jelena Roganovic Lea Saric Silvije Segulja Ana Dordevic Mia Radosevic Department of Pediatrics Clinical Hospital Centre RijekaRijeka 51000Croatia Faculty of Medicine University of RijekaRijeka 51000Croatia Faculty of Health Sciences University of RijekaRijeka 51000Croatia Department of Business Development Jadran Galenski LaboratorijRijeka 51000Croatia

BACKGROUND suprasellar germinomas are rare intracranial tumors frequently associated with permanent endocrine *** present the clinical picture,treatment,and complications of suprasellar germinoma at pediatric age which,besides being lifethreatening,has lifelong endocrinological *** SUMMARY A 12-year-old female patient was presented having had intensive headaches for three weeks and visual disturbances for six *** ophthalmological examination revealed bilateral papilledema and a marked loss of *** brain magnetic resonance imaging(MRI)showed a suprasellar tumor,involving the infundibulum and the optic chiasm,extending to the third *** tests confirmed decreased levels of thyroxine,cortisol,gonadotropins,and insulin-like growth factor *** tumor reduction was performed,and immunohistopathology established the diagnosis of suprasellar *** of the spine and cerebrospinal fluid cytology confirmed the localized *** chemotherapy and radiotherapy were performed according to the SIOP CNS GCT II protocol.A post-treatment MRI showed no residual tumor,but pituitary function had not *** and a half years after the end of the treatment,the patient is in a complete remission,requiring hormonal replacement therapy,continuous education,and psychological *** This complex case highlights the importance of timely diagnosis,a multidisciplinary approach,and close follow-up in children with suprasellar germinomas.

关键词： Germinoma Germ cell tumor suprasellar tumor Hypopituitarism Management Pediatrics Case report

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Trans-eyebrow supraorbital endoscope-assisted keyhole approach to suprasellar meningioma in pediatric patient:case report and literature review

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Chinese Neurosurgical Journal 2023年第1期9卷 65-74页

作者： Elizaveta I.Safronova Suzanna A.Galstyan Yury V.Kushel Pediatric Neurosurgery Department Burdenko Neurosurgical Center164th Tverskaya-Yamskaya StMoscowRussia Pathology Department Burdenko Neurosurgical Center164th Tverskaya-Yamskaya StMoscowRussia

Background:Meningiomas are rather uncommon tumors in the pediatric population,differing significantly from those found in adults by their atypical location,higher rate of more malignant types,consequently higher risk of recurrence and a less favorable *** in children,suprasellar meningiomas without dural matrix are rare findings mimicking more common suprasellar *** presentation:Here we describe a case of a 12-year-old girl who presented with a rapidly progressing chiasmal syndrome and was diagnosed by MRI with an unusual suprasellar tumor that could not fit the diagnoses expected in a case of a parasellar mass in a child,similar to a craniopharyngioma or optic pathway *** multiple clinical investigations,the tumor etiology was still unclear,so the preferred option of treatment was surgical *** endoscope-assisted gross total resection through a supraorbital keyhole approach was performed uneventfully,with total vision recovery in a short *** meningiomas located in the skull base without dural attachment appear to be rare,even in pediatric ***:Differential diagnoses of suprasellar and para sellar tumor lesions in pediatric patients can be *** are peculiar features of pediatric tumor diseases that should be considered while working out the management *** main principle of meningioma treatment is the highest possible extent of resection minimally affecting the quality of life.

关键词： Pediatric meningioma suprasellar tumor Chiasmal syndrome Pediatric neurosurgery Keyhole supraorbital approach Endoscopic assistance

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