检索结果-南通市图书馆

Hybrid supraparticles of carbon dots/porphyrin for multifunctional tongue-mimic sensors

Chinese Chemical Letters 2022年第5期33卷 2715-2720页

作者： Rong Hu Xingchun Zhai Yubin Ding Guoyue Shi Min Zhang School of Chemistry and Molecular Engineering Shanghai Key Laboratory for Urban Ecological Processes and Eco-RestorationShanghai Key Laboratory of Multidimensional Information ProcessingEngineering Research Centre for Nanophotonics and Advanced Instrument(Ministry of Education)East China Normal UniversityShanghai 200241China Department of Chemistry College of SciencesNanjing Agricultural UniversityNanjing 210095China

supraparticles(SPs),such as assembly of inorganic components with organic,have made tremendous attention in biochemical analysis,which represents a novel but challenging research ***,a single-SPs multifunctional fluorescent sensor array has been developed for high-throughput detection of heavy metal ions in biofluids,which is based on an inorganic/organic hybrid SPs consisting of carbon dots(CDs)and an easily available porphyrin[5,10,15,20-tetra(4-carboxyphenyl)porphyrin(TCPP)].TCPP can aggregate with the CDs to form the assembly(CDs/TCPP SPs)through the electrostatic andπ-πstacking *** are two independent and clearly separated fluorescence emission peaks at 470 and 668 nm in the resultant CDs/TCPP SPs under 380 nm *** a proof-of concept design,F 470,F 668,F 668/F 470 of SPs are chosen as three sensor components to constitute our sensor *** the addi-tion of metal ions,three sensor components can generate different fluorescence response patterns for discriminating 11 heavy metal ions via principal component analysis(PCA).Additionally,thiols can read-ily capture Cu^(2+)to switch the fluorescence of CDs/TCPP initially altered by Cu^(2+).Hence,CDs/TCPP-Cu^(2+)ensemble is further demonstrated to be a powerful sensor array for pattern recognition of 7 thiols and even chiral recognition of cysteine *** novel strategy avoids the tanglesome synthesis of multiple sensing probes and dedicates an innovative method for the facile establishment of tongue-mimic sensors,which would prospectively sprout more homologous assumptions to broaden its application toward more biosensing fields.

关键词： supraparticles Carbon dots Porphyrin Pattern recognition sensor array Heavy metal ions Thiols

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chiral Cu_(x)Co_(y)S supraparticles Ameliorate Parkinson’s Disease

引用

CCS Chemistry 2022年第7期4卷 2440-2451页

作者： Baimei Shi Aihua Qu Weiwei Wang Meiru Lu Zhuojia Xu Chen Chen Changlong Hao Maozhong Sun Liguang Xu Chuanlai Xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection Jiangnan UniversityWuxiJiangsu 214122 State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxiJiangsu 214122

Protein aggregation causes alpha-synuclein(α-syn)to change from its original physiological role to a pathological state,which is a potential pathogenic mechanism in Parkinson’s disease(PD).Chiral _(L/D)-Cu_(x)Co_(y)S supraparticles(_(L/D)-SPs)with a circular dichroism value of 35 mdeg at 805 nm were fabricated using a simple wet-chemical *** _(L/D)-SPs prevented the α-syn monomers from forming fibrils and triggered the α-syn fibrils to turn into monomers under 808 nm near-infrared(NIR)*** living MN9D cells,D-SPs reduced cellular damage,neuronal functional deficits,and neuron loss caused by α-syn fibrils after NIR spectroscopy treatment within 10 min to prevent α-syn ***,the reactive oxygen species produced by _(D)-SPs were 1.42 times higher than those produced by _(L)-*** vivo experiments showed that _(D)-SPs had a protective effect on neuron damage caused by α-syn aggregate deposition,reduced the symptoms in a mouse model of PD,and restored cognitive *** NIR light treatment,the amount of α-syn in a mouse model of PD decreased by more than 67.5%.At the same time,_(D)-SPs gradually decomposed into small nanoparticleswithin 60 days and were excreted through the blood-brain *** discovery paves theway for the treatment of neurodegenerative diseases using chiral SPs under NIR light irradiation.

关键词： chirality Cu_(x)Co_(y)S supraparticles α-synuclein Parkinson’s disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：