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Science China Chemistry 2004年第4期47卷 340-348页

作者： GAO Ziwei ZHAO Xiaopeng SUN Ping SI Gang Institute of Electrorheological Technology141# Department of Applied PhysicsNorthwestern Polytechnical UniversityXian 710072China Department of Chemistry School of Chemistry and Material ScienceShaanxi Normal UniversityXi’an 710062China

According to the chemical design, electrorheological properties of supramolecular complex from β-cyclodextrin polymer (β -CDP) were discussed. Six supramolecular complexes of β-cyclodextrin polymer with substituted salicylic acid and 3-hydroxy-2-naphthoic acid were synthesized by the solid-phase self-assembly method, and their component and structure were characterized by NMR, FT-IR, UV-vis and the fluorescence analysis. Then the electrorheological properties of their suspensions in silicone oil were investigated under DC electric fields. It was found that the yield stresses of these supramolecular complex ER fluids were 7.3–9.8 kPa at 4 kV/mm in DC electric field, which were enhanced by 34%–72% compared with that of pure β-CDP. Among them, that of β-CDP/3-hydroxy-2-naphthoic acid ER fluid was the highest. It was also found that the ER effect of supramolecular complexes can be controlled by changing different guests. When the substituted group is at phenyl ring, ER behavior can be slightly adjusted by the different substituted groups, their number as well as their position at phenyl ring. This can be proved by the measurement of dielectric properties.

关键词： electrorheological fluids β-cyclodextrin crosslinking polymer substituted salicylic acid 3-hydroxy-2-naphthoic acid supramolecular complex

supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery

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Chinese Chemical Letters 2024年第2期35卷 317-322页

作者： Han Lin Yanchun Li Kun Zhou Dan Li Hangyan Yu Jie Zhao Haofei Hong Zhifang Zhou Zhimeng Wu Key Laboratory of Carbohydrate Chemistry & Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of ***,an essential requirement of this approach is to generate high titers of endogenous antibodies in vivo through pre-immunization,which complicates the immunization procedure and may cause side ***,we report a new generation of APC-targeting TACA-based supramolecular complex vaccine,assembled by sialyl Thomsen-nouveau-bovine serum albumin-adamantine(sTn-BSA-Ada)and heptavalent rhamnose(Rha)-modifiedβ-cyclodextrin(β-CD)via host-guest *** complex vaccine retained anti-Rha antibodies recruiting capability and facilitated the APCs uptake of the vaccine via the interaction of the Fc-domain with the Fc receptors on *** demonstrate that direct immunization of complex vaccine elicited anti-Rha and anti-sTn specific immune response synchronously,generating a novel self-enhancement effect that can improve the antigen delivery to APCs in high *** structure-activity relationship(SAR)study proved that complex vaccine 4 with polyethylene glycol 6(PEG 6)linker in host molecule provoked a robust and specific sTn immune response comparable to the pre-immunization *** antisera induced by complex vaccine,either through direct immunization or pre-immunization,exhibited equal potency of cytotoxicity against the sTn expression cancer *** study provides a general platform for TACA-based vaccines with self-enhancement effects without the need for pre-immunization.

关键词： Glycoconjugate vaccine Endogenous antibody APC-targeting supramolecular complex sTn antigen

Study of a water-soluble supramolecular complex of curcumin andβ-cyclodextrin polymer with electrochemical property and potential anti-cancer activity

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Chinese Chemical Letters 2022年第8期33卷 4043-4047页

作者： Wang Zhang Ping Xiao Liwei Lin Fang Guo Qingyue Wang Yuanzhe Piao Guowang Diao School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySuwon 443-270Republic of Korea Shanghai Suni Biotechnology Development Co. Ltd.Shanghai 201300China Advanced Institutes of Convergence Technology Suwon 443-270Republic of Korea

As a member of the curcuminoid compound family,curcumin(Cur)has many interesting therapeutic ***,its low aqueous solubility and stability have resulted in poor bioavailability and restricted clinical *** on size matching,β-cyclodextrin polymer(β-CDP),with its hydrophilic polymer chains and hydrophobic cavities,can form an inclusion complex with *** improve the water solubility and stability of Cur,a simple and eco-friendly grinding method was designed to formβ-CDP inclusion *** to the Boltzmann-Hamel's method and Job's method,the molar ratio of theβ-CD unit inβ-CDP to Cur was determined to be 1:*** diffusion coefficient and diffusion activation energy of Cur-β-CDP were calculated in an electrochemical *** supramolecular complex worked well in vitro to inhibit the proliferation of hepatoma carcinoma cells ***,this method visibly reduced the undesirable side effects on normal cells,without weakening the anti-cancer activity of the *** expect that the obtained host-guest complex will provide a new approach for delivering natural drug molecules,having low water solubility.

关键词： Cyclodextrin polymer Curcumin Solubility Anti-cancer activity supramolecular complex

~1H NMR Investigation of supramolecular complex between β-Cyclodextrin and Cholesterol

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Wuhan University Journal of Natural Sciences 2011年第1期16卷 79-82页

作者： JIANG Huiming ZHANG Shufen SHI Qi JIA Ying State Key Laboratory of Fine Chemicals Dalian Universityof Technology Dalian 116012 China College of Life Science Dalian Nationalities UniversityDalian 116600 China

A supramolecular complex between β-cyclodextrin and cholesterol was synthesized and characterized via proton 1H NMR spectroscopy. In the supramolecular complex,the stoichiometric proportion of β-cyclodextrin to cholesterol is 1：2. The possible conformation of the supramolecular complex was depicted according to the chemical shift variance of proton 1H NMR of the host and guest molecules inside the inclusion complex. Removal efficiency of cholesterol complexed by β-cyclodextrin in our work is increased to a remarkable extent. This result can be applied in the field of drug development to reduce cholesterol in blood and other human organs.

关键词： supramolecular complex β-cyclodextrin (β-CD) 1H NMR cholesterol conformation

A Novel Self-assembled supramolecular complex {[Cu(II)(en)_2·[JP]H_2O] [Cu(I)_2(CN)_4]}_n with Honeycomb-like Structure and Its Adsorption Properties

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Chinese Journal of Chemistry 2002年第12期20卷 1472-1476,1459页

作者：沈小平邹建忠李宝龙胡怀民徐正

A novel supramolecular complex {[Cu(II)(en) 2·H 2O]· [Cu(I) 2(CN) 4]} n (en=ethylenediamine), in which the cyanide-bridged Cu(I) forms the honeycomb-like skeleton host and the Cu(II) complex ion [Cu(en) 2·H 2O] 2+ is encapsulated in the center of the channel cavity of the skeleton, was synthesized by two different methods. The complex was also characterized by elemental analysis, ICP analysis, IR spectra and thermal analysis. The adsorption and desorption studies of the complex indicate that H 2O and NH 3 can be desorbed and re-adsorbed without collapse of the channel structure of the supramolecule.

关键词： crystal structure cyano-bridged copper complex adsorption properties supramolecular complex

A Hydrogen-Bonding Network Constructed from N-[(4-carboxyphenyl)-sulfonyl]glycine and 2,2'-bipyridine Spacer:Synthesis,Structure and Thermal Property of A Cobalt supramolecular complex

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A Hydrogen-Bonding Network Constructed from N-[(4-carboxyphe...

Hydrothermal Synthesis,Crystal Structure and Thermal Stability of a supramolecular Lead(II) complex with 4-Nitrobenzoic Acid and 1,10-Phenanthroline

2010中西部地区无机化学化工学术研讨会

作者：王永伟王利亚 Department of Chemistry and Chemical Engineering Ankang University College of chemistry and chemical engineering Luoyang normal university

Utilizing N-[(4-carboxyphenyl)-sulfonyl]glycine(abbreviated as cbsglyH),a new cobalt complex[Co(cbsglyH)(bipy)]·9.5HO(bipy=2,2’-bipyridine) has been synthesized under mild conditions and characterized by IR,elemental analysis,thermogravimetric analysis and X-ray diffraction *** title complex is a monomeric compound which is further assembled by intermolecular hydrogen bonds andπ-πinteraction into a 3-D supramolecular network.A discrete(HO) cluster and a puckered eight-membered ring have been observed in this *** analysis illustrates that this complex begins decomposing at 30℃and and decompounding completely at 445℃.

关键词： N-[(4-carboxyphenyl)-sulfonyl]glycine supramolecular complex thermal property (H2O)18 cluster

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Chinese Journal of Structural Chemistry 2012年第5期31卷 639-644页

作者：徐相君吴向阳徐婉珍周威闫永胜 School of Environment Jiangsu University School of Chemistry and Chemical Engineering Jiangsu University

A new complex [Pb（phen）2（4-NBA）]2·2（NO3）·H2O（phen = 1,10-phenanthroline,4-NBA = 4-nitrobenzoate） has been hydrothermally synthesized and structurally determined by single-crystal X-ray diffraction,elemental analyses and IR *** complex crystallizes in monoclinic,space group P21/c with a = 13.416（3）,b = 14.065（3）,c = 16.845（3）（A°） ,β = 110.55（3）o,V = 2976.5（10）（A°）^3,Z = 2,Dc = 1.796 g/cm^3,F（000） = 1564,GOOF = 0.962,the final R = 0.0686 and wR = *** crystal structure shows that the lead ion is coordinated with two carboxylate O atoms from the 4-NBA anion,and four N atoms from two phen molecules,forming a slightly distorted pentagonalbipyramidal coordination *** is further extended by various supramo-lecular interactions to form a three-dimensional supramolecular *** TG analysis result shows that this complex begins decomposing at 30 ℃ and decompounding completely at 733 ℃.

关键词： crystal structure π…π supramolecular complex thermal stability analysis

supramolecular complexes Self-assembled by Copper（Ⅱ） Carboxylate and Monohelical Pyridylamino Ligand

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Chinese Journal of Chemistry 2006年第3期24卷 365-370页

作者：周利君王萃娟王尧宇刘萍周彩华史启祯 Shaanxi Key Laboratory of Physico-inorganic Chemistry Department of Chemistry Northwest University Xi'an Shaanxi 710069 China

Two novel supramolecular complexes [Cu（bpapa）（dhbd）]·CHaOH （1） and [Cu（bpapa）（ma）]·ma （2）（bpapa= bis[6-（2-pyridylamino）pyrid-2-yl]amine, dhbd=2,3-dihydroxybutanedioate dianion, ma=a-methacrylate） were rationally designed, synthesized and characterized by single crystal X-ray diffraction, IR, electronic spectroscopy and thermogravimetric analyses. complex 1 was the first oligo-a-pyfidylamino complex based on hydroxypolycarboxylate and self-assembled into a 3D honeycomb configuration network with open channels and tubes containing 1D ladder-shaped double chains formed by hydrogen bonds and aromatic π-π stacking interactions. complex 2 constructed a 2D supramolecular network extended by 1D chains from dimeric supramolecular synthon through noncovalent supramolecular interactions. In the two complexes, the chelating monohelical ligand adopted all-anti configuration. Density functional theory calculations were applied to 1 and 2.

关键词： monohelical pyridylamino copper(Ⅱ) carboxylate supramolecular complex

Crystal Structures and Theoretical Calculation of Zn（Ⅱ） and Cu（Ⅱ） supramolecular complexes Based on Macrocyclic Triamine Ligand 1,4,7-Triazacyclodecane （tacd）

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Chinese Journal of Chemistry 2007年第6期25卷 784-790页

作者：郭惠朱海燕何贤玲苏振萍李珺张逢星 Department of Chemistry Northwest University Shaanxi Key Laboratory of Physicoinorganic Chemistry Xi'an Shaanxi 710069 China Department of Chemistry and Chemical Engineering Weinan Teacher's College Weinan Shaanxi 714000 China 不详

Two supramolecular complexes [Zn（tacd）2]（C6H8O4）·6H2O（1） and [Cu（tacd）2]Cl2·4H2O（2） were synthesized and characterized by elemental analysis, IR spectra, TGA and single-crystal X-ray diffraction analysis. The crystal structure showed that the metal ions in complexes 1 and 2 had similar coordination circumstance. But for the complex 2, it formed a novel two-dimensional supramolecular network with 12-membered rings and four-membered rings via hydrogen bond interaction. The thermal gravimetric analyses indicated that the two complexes had similar steps of weight-loss. On the basis of experiment, the two complexes were calculated by DFT-B3LYP/6-31G（d） in Gaussian 03. The results of calculation are in good agreement with the experiment.

关键词： supramolecular complex hydrogen bond 1,4,7-triazacyclodecane TGA theoretical calculation

Virus-like supramolecular assemblies formed by cooperation of base pairing interaction and peptidic association

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Science China Chemistry 2016年第3期59卷 310-315页

作者： Meiwen Cao Ningning Wang Peng Zhou Yawei Sun Jiqian Wang Shengjie Wang Hai Xu Centre for Bioengineering and Biotechnology State Key Laboratory of Heavy Oil ProcessingCollege of Chemical EngineeringChina University of Petroleum(East China)Qingdao266555China

A peptide nucleic acid （PNA）-peptide conjugated molecule, T＇3（AKAE）2, was designed to have both a PNA segment for oligo- nucleotide binding and an ionic self-complementary peptide sequence for self-association. T＇3（AKAE）2 could co-assemble with oligoadenines （d（A）x） to form virus-like supramolecular structures whose morphology showed dependence on the chain length and rigidity of the d（A）x molecules. Smaller nanospheres with diameters of 13.0±2.0 nm were produced in the case of d（A）6. Wormlike aggregates with lengths of 20-50 nm and diameters of 15.0±2.5 nm were found in the cases of d（A）12, d（A）ls, d（A）24 and d（A）30. And larger spherical aggregates with diameters of 18±5 nm came into presence in the cases of d（A）36 and d（A）42＋. These nanostructures were suggested to be formed under a cooperative effect of base pair recognition and peptidic association. The study provides insights into the programmed assembly of a multi-components system as well as control of the size and shade of the co-assembled structures, which is of great significance in develouing gene/drug deliverv systems.

关键词： peptide nucleic acid oligonucleotide artificial virus co-assembly supramolecular complex