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superparamagnetic CoFe2O4@Au with High Specific Absorption Rate and Intrinsic Loss Power for Magnetic Fluid Hyperthermia Applications

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Acta Metallurgica Sinica(English Letters) 2019年第6期32卷 719-725页

作者： Sandip Sabale Vidhya Jadhav Shubhangi Mane-Gavade Xiao-Ying Yu Earth and Biological Sciences Directorate PNNLRichland.WA 99352USA Department of Chemistry Jaysingpur College JaysingpurShivaji UniversityKolhapurMS 416101India

CoFe2O4 nanoparticles(NPs)and surface modified with gold(Au)have been synthesized by a thermal decomposition method.The obtained NPs and formation of CoFe2O4@Au core–shell(CS)were confirmed by characterizing their structural and optical properties using X-ray powder diffraction(XRD)patterns,Fourier transform infrared spectroscopy,Raman spectroscopy,UV–Visible and photoluminescence studies.Morphological and compositional studies were carried out using high-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy,while the magnetic properties were determined using alternating gradient magnetometer and Mossbauer to define the magneto-structural effects of shell formation on the core NPs.Induction heating properties of CoFe2O4 and CoFe2O4@Au CS magnetic nanoparticles(MNPs)have been investigated and correlated with magneto-structural properties.Specific absorption rate and intrinsic loss power were calculated for these MNPs within the human tolerable range of frequency and amplitude,suggesting their potential in magnetic fluid hyperthermia therapy for possible cancer treatment.

关键词： CoFe2O4@Au superparamagnetic Specific absorption rate(SAR) Intrinsic loss power(ILP) Magnetic fluid hyperthermia

Biodistribution and Toxicity Assessment of superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo

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Current Medical Science 2018年第6期38卷 1096-1102页

作者： Qin YU Xiao-qin XIONG Lei ZHAO Ting-ting XU Hao BI Rong FU Qian-hua WANG Department of Clinical Laboratory Wuhan Blood CenterWuhan 430000China School of Chemistry and Life Science Hubei University of EducationWuhan 430205China Department of Obstetrics and Gynecology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China

Biodistribution and toxicity assessment are critical for safe clinical use of newly developed medicines.superparamagnetic iron oxide nanoparticles (SPION)are effective carriers for targeted drug delivery.This study aimed to examine the toxicity and biodistribution of SPION coated with polyethylenimine (PEI)(SPION-PEI)designed for small interfering RNA (siRNA) delivery both in vitro and in vivo.SPION-PEI/siRNA complexes were prepared at different weight ratios.Cytotoxic effects of SPION-PEI/siRNA on HSC-T6 cell viability were determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT).Rats were divided into three groups:a control group,a normal-saline group and a SPION-PEI/siRNA group.After a single intravenous injection,in vivo nanoparticle biodistribution and accumulation were evaluated by Prussian blue staining in the heart,liver,spleen,lung and kidney 8 h,24 h,and 7 days after the injection.Their distribution was histologically studied at the three time points by measuring ironpositive areas (μm2)in organ sections stained with Prussian blue.The same organs were analyzed by H&E staining for any possible histopathological changes.Furthermore,biochemical indexes such as alanine amino transaminase (ALT),aspartate transaminase (AST),blood urea nitrogen (BUN)and creatinine (CREA)were also assessed at all experimental time points.Electrophoresis exhibited that the SPION-PEI could retard siRNA altogether at weight ratios above 4.MTT assay showed that SPION-PEI loaded with siRNA had low cytotoxicity.In vivo study revealed that the liver and spleen were the major sites of SPION-PEI/siRNA deposition.The iron content was significantly increased in the liver and spleen,peaking 24 h after intravenous injection and then declining gradually.No evidence was found of irreversible histopathological damage to any of the organs tested.These results suggested that most SPION-PEI/siRNA complexes were distributed in the liver and spleen,which might be the target organs of SPION-PEI/siRNA complexes.SPION- PE

关键词： superparamagnetic iron oxide nanoparticles toxicity biodistribution Prussian blue staining

Nanosized Pd assembled on superparamagnetic core–shell microspheres:Synthesis,characterization and recyclable catalytic properties for the Heck reaction

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Chinese Chemical Letters 2014年第9期25卷 1265-1270页

作者： Hao Yang Da Shi Sheng-Fu Ji Dan-Ni Zhang Xue-Fei Liu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

A series of magnetically recyclable Pd/Fe3O4@γ-Al2O3 catalysts were synthesized using the superparamagnetic Fe3O4@γ-Al2O3 core-shell microspheres as the supporter and nano-Pd particles assembled on γ-Al2O3 shell as the active catalytic component. The structure of the catalysts was characterized by X-ray diffraction （XRD）, transmission electron microscopy iTEM）, N2 adsorptiondesorption and vibrating sample magnetometer （VSM）. The catalytic activity and the recyclability properties of the catalysts for the Heck coupling reaction with aryl bromides and the olefins were investigated. The results show that the microspheres of the magnetic Pd/Fe304@γ-Al2O3 catalysts were about 400 nm and the nano-Pd particles assembled on γ-Al2O3 shell were about 3-4 nm in size. The saturation magnetization （MS） of the magnetic catalysts was sufficiently high to allow magnetic separations. In the Heck coupling reactions, the magnetic Pd/Fe304@γ-Al2O3 catalysts exhibited good catalytic activity and recyclability. With Pd/Fe304@γ-Al2O3 （0.021 mol%） catalyst, the bromobenzene conversion and product yield reached about 96.8% and 91.2%, respectively, at 120℃ and in 14 h. After being recycled for six times, the conversion of bromobenzene and the recovery of the catalyst were about 80% and 90%, respectively. The nano-Pd particles were kept well dispersed in the used Pd/Fe304@γ-Al2O3 catalysts.

关键词： Nano-Pd superparamagnetic Core-shell Catalyst Heck reaction

Fabrication of magnetically responsive anti-fouling and easy-cleaning nanofiber membrane and its application for efficient oil-water emulsion separation

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Chinese Journal of Chemical Engineering 2022年第1期35卷 286-293页

作者： Yajie Wang Zhiwei Guo Yujie Yang Yanxiang Li Qingchun Guo Peilin Cui Wangliang Li CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Hebei Lansheng Biotech Co. LtdShijiazhuang 052200China International Medical Service Beijing Tiantan Hospital Affiliated to Capital Medical UniversityChina

The magnetically responsive anti-fouling nanofiber membrane(MRANM)was fabricated for efficient oilwater emulsion separation,which could be cleaned using oscillating magnetic field.MRANM was prepared by grafting superparamagnetic Fe_(3)O_(4) nanoparticles onto the surface of electrospun polyacrylonitrile nanofiber membrane(PANM).Compared with PANM,the water contact angle of MRANM decreased from 104°to 0°,indicating that the hydrophilicity of the membrane was significantly improved.For the emulsions of hexadecane,octane and rapeseed oil,the separation efficiency was 98.04%,96.59%and 92.67%,respectively.After the treatments in oscillating magnetic field,the separation efficiency kept above 95%after 8 times recycling,which indicated that the MRANM had good regenerability and reusability.The as-fabricated membrane with magnetic responsiveness facilitated an effective method for solving the membrane fouling problem during practical applications of separation high viscosity oil-water emulsion.

关键词： superparamagnetic Nanofiber membrane Anti-fouling Oil-water emulsion Regeneration

Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging

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World Journal of Gastroenterology 2015年第47期21卷 13400-13402页

作者： Yi-Xiang J Wang Department of Imaging and Interventional Radiology Faculty of Medicine the Chinese University of Hong Kong

Five types of superparamagnetic iron oxide （SPIO）,i.e. Ferumoxides （Feridex？ Ⅳ, Berlex Laboratories）,Fe r u c a r b o t ra n （ Re s ov i s t？, B aye r H e a l t h c a re ） ,Ferumoxtran-10 （AMI-227 or Code-7227, Combidex？, AMAG Pharma; Sinerem？, Guerbet）, NC100150（Clariscan？, Nycomed,） and （VSOP C184, Ferropharm）have been designed and clinically tested as magneticresonance contrast agents. However, until nowResovist？ is current available in only a few countries.The other four agents have been stopped for furtherdevelopment or withdrawn from the market. AnotherSPIO agent Ferumoxytol （Feraheme） is approved forthe treatment of iron deficiency in adult chronic kidneydisease patients. Ferumoxytol is comprised of ironoxide particles surrounded by a carbohydrate coat, andit is being explored as a potential imaging approach forevaluating lymph nodes and certain liver tumors.

关键词： superparamagnetic iron oxide liver hepatocellularcarcinoma magnetic resonance imaging Resovist Gd-EOB-DTPA Primovist Eovist

Distribution of c-erbB2 Antisense Probe Labeled with superparamagnetic Iron Oxide Nanoparticles in the Major Organs of Mice on MR Imaging

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Advances in Nanoparticles 2013年第1期2卷 16-20页

作者： Zhipeng Wen Haiyan Liu Hairong He Shude Tan Ming Wen Shaolin Li Department of Radiology The First Affiliated Hospital Chongqing Medical University Chongqing China

Background: The aim of this study was to investigate the distribution of the c-erbB2 antisense probe labeled with superparamagnetic iron oxide nanoparticles in the major organs of mice by MR imaging. Methods: Sixty BALB/c mice were randomly divided into experimental and control groups. MR scans were performed in each mouse of the experimental group at five different time points (10, 30, 60, 180 and 360 min) after injection of the antisense probe. The signal from each major organ (liver, spleen, heart, kidney and muscle tissue) in comparison with the background signal (signal to noise ratio) was determined at each time point as a measure of the distribution of the antisense probe. Six control mice were killed at each of the same time points and the organs immediately removed for determination of their iron content. Results: After injection of the antisense probe, the highest enrichment of the probe was seen in the spleen, reaching a peak at 180 min, followed by the liver, muscle, heart and kidney. Conclusions: MR imaging can visualize the distribution of c-erbB2 antisense probe labeled with superparamagnetic iron oxide nanoparticles in the major organs of mice, and this may provide the basis for further in vivo studies of MR imaging time and dose selection.

关键词： Antisense Oligodeoxynucleotide superparamagnetic Iron Oxide Mr Imaging Iron Concentration Vivo Distribution

Development and in vitro study of a bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第24期25卷 3030-3043页

作者： Xiao-Hong Ma Shuang Wang Si-Yun Liu Kun Chen Zhi-Yuan Wu Deng-Feng Li Yong-Tao Mi Long-Bin Hu Zhong-Wei Chen Xin-Ming Zhao Department of Diagnostic Radiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China GE Healthcare (China) Beijing 100176China State Key Laboratory of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100021China

BACKGROUND Hepatocellular carcinoma(HCC)ranks second in terms of cancer mortality worldwide.Molecular magnetic resonance imaging(MRI)targeting HCC biomarkers such as alpha-fetoprotein(AFP)or glypican-3(GPC3)offers new strategies to enhance specificity and help early diagnosis of HCC.However,the existing iron oxide nanoparticle-based MR molecular probes singly target AFP or GPC3,which may hinder their efficiency to detect heterogeneous micro malignant HCC tumorssuperparamagnetic iron oxide nanoparticle(USPIO).At the same time,the singly labeled probes of anti-AFP-USPIO(UA)and anti-GPC3-USPIO(UG)and non-targeted USPIO(U)were also prepared for comparison.The physical characterization including morphology(transmission electron microscopy),hydrodynamic size,and zeta potential(dynamic light scattering)was conducted for each of the probes.The antigen targeting and MRI ability for these four kinds of USPIO probes were studied in the GPC3-expressing murine hepatoma cell line Hepa1-6/GPC3.First,AFP and GPC3 antigen expression in Hepa1-6/GPC3 cells was confirmed by flow cytometry and immunocytochemistry.Then,the cellular uptake of USPIO probes was investigated by Prussian blue staining assay and in vitro MRI(T2-weighted and T2-map)with a 3.0 Tesla clinical MR scanner.RESULTS Our data showed that the double antibody-conjugated probe UAG had the best specificity in targeting Hepa1-6/GPC3 cells expressing AFP and GPC3 antigens co

关键词： Hepatocellular carcinoma Molecular imaging Magnetic resonance imaging Ultra-small superparamagnetic iron nanoparticles Alpha-fetoprotein Glypican-3

Growth of monodisperse nanospheres of MnFe_2O_4 with enhanced magnetic and optical properties

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Chinese Physics B 2013年第10期22卷 453-459页

作者： M.Yasir Rafique 潘礼庆 Qurat-ul-ain Javed M.Zubair Iqbal 邱红梅 M.Hassan Farooq 郭振刚 M.Tanveer College of Science and Research Institute for New Energy China Three Gorges University Department of Physics University of Science and Technology of Beijing School of Material Science and Engineering University of Science and Technology of Beijing Research Center of Materials Science Beijing Institute of Technology

Highly dispersive nanospheres of MnFe204 are prepared by template free hydrothermal method. The nanospheres have 47.3-nm average diameter, narrow size distribution, and good crystallinity with average crystallite size about 22 nm. The reaction temperature strongly affects the morphology, and high temperature is found to be responsible for growth of uniform nanospheres. Raman spectroscopy reveals high purity of prepared nanospheres. High saturation magnetization （78.3 emu/g）, low coercivity （45 Oe, 10e = 79.5775 A.cm-1）, low remanence （5.32 emu/g）, and high anisotropy constant 2.84 × 10^4 J/m3 （10 times larger than bulk） are observed at room temperatures. The nearly snperparamagnetic behavior is ~ spin due to comparable size of nanospheres with superparamagnetic critical thameter Dcr spm The high value of Keff may be due to coupling between the pinned moment in the amorphous shell and the magnetic moment in the core of the nanospheres. The nanospheres show prominent optical absorption in the visible region, and the indirect band gap is estimated to be 0.98 eV from the transmission spectrum. The prepared Mn ferrite has potential applications in biomedicine and photocatalysis.

关键词： Mn ferrite magnetic materials hydrothermal method superparamagnetic Raman spectroscopy

Simultaneous acquisition of Fe3O4 monocrystals:Tunable magnetic properties with various morphologies

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Progress in Natural Science:Materials International 2020年第1期30卷 41-46页

作者： Zemin Zheng Yiming Cao Zhe Li Huiyong Li Dafeng Hu Hao Jiang Xuemin Geng Jiangwei Lu Xudong Zhang Peng Yang Yanfen Wan School of Materials Science and Engineering Yunnan Key Laboratory for Micro/nano Materials & TechnologyYunnan University Center for Magnetic Materials and Devices & Key Laboratory for Advanced Functional and Low Dimensional Materials of Yunnan Higher Education Institute Qujing Normal University

Fe3O4nanoparticles(NPs) with a face-centered cubic(fcc) structure and two different morphologies(nanospheres and nanoprisms) were synthesized by a facile one-step method.The synthesized Fe3O4nanospheres and nanoprisms were monocrystalline and separable in a magnetic field.In different volume ratios of oleylamine(OAm) to dibenzyl ether,the sizes of the prepared Fe3O4NPs ranged from 5 to 21 nm.The OAm amount in the synthesis can significantly control the morphology of Fe3O4NPs.As the OAm content increased from 10 ml to 30 ml,the faceted nanoprisms shrank while the nanospheres enlarged.At an OAm content of 25 ml,the nanoprisms diminished while more hexagonal and sphere-like particles appeared,implying a critical point of morphology transition from triangle to hexagon.The magnetic properties also depended on the NP morphology and size.The prepared Fe3O4NPs are promising candidates in medical applications such as magnetic resonance imaging,targeted drug delivery,blood purification,and tumor hyperthermia.

关键词： Fe 3 O 4 Nanoparticles Nanoprism Nanosphere superparamagnetic