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Assessing keloid recurrence following surgical excision and radiation

Burns & Trauma 2020年第1期8卷 34-40页

作者： Michael H.Gold Mark S.Nestor Brian Berman David Goldberg Gold Skin Care Center 2000 Richard Jones RoadSuite 220NashvilleTN 37215 Center for Clinical and Cosmetic Research 2925 NE 199th StSuite 205AventuraFL 33180 Department of Dermatology and Cutaneous Surgery University of Miami Miller School of MedicineMiamiFL Skin Laser&Surgery Specialists of NY/NJ 110 E.55th Street13th floorNew YorkNY 10022

Keloids are a fibroproliferative disorder that can result from a cutaneous injury to the reticular *** rates as high as 100%have been reported following surgical excision ***,a variety of post-surgical techniques have been employed to prevent keloid recurrence,including the use of *** numerous studies have shown post-excisional X-rays,electron beam,lasers and brachytherapy can reduce the rate of keloid recurrence,numerous inconsistencies,including a wide range of definitions for keloid recurrence,make it difficult to compare study *** review aims to examine the various means for defining keloid recurrence in clinical trials involving the use of radiation *** of the Cochrane Library and PubMed were performed to identify the available information for post-surgical keloid recurrence following radiation *** identified study was reviewed for patient followup and criteria used to define keloid *** search results included clinical studies with external beam radiation,brachytherapy and superficial radiation *** studies did not include a definition of keloid recurrence,or defined recurrence only as the return of scar *** studies defined keloid recurrence based on patient self-assessment questionnaires,symptoms and scar elevation and changes in Kyoto Scar Scale,Japan Scar Workshop Scale and Vancouver Scar Scale *** results of this review indicate keloidectomy followed by radiation therapy provide satisfactory recurrence rates;however,clinical studies evaluating these treatments do not describe treatment outcomes or use different definitions of keloid ***,recurrence rates vary widely,making comparisons across studies *** recurrence should be clearly defined using both objective and subjective measures.

关键词： Keloid Keloid scar Recurrence External beam radiation Brachytherapy superficial radiation therapy

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