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Structure and expression of sulfatase and sulfatase modifying factor genes in the diamondback moth,Plutella xylostella

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Insect Science 2018年第6期25卷 946-958页

作者： Xiao-Li Ma Wei-Yi He Wei Chen Xue-Jiao Xu Wei-Ping Qi Ming-Min Zou Yan-Chun You Simon W.Baxter Ping Wang Min-Sheng You State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry UniversityFuzhouChina. Institute of Applied Ecology Fujian Agriculture and Forestry UniversityFuzhouChina. Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests Fujian Agriculture and Forestry UniversityFuzhouChina. Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops Ministry of AgricultureFuzhouChina. Department of Entomology Comell UniversityNew York State Agricultural Experiment StationGenevaNYUSA . School of Biological Sciences University of AdelaideSouth AustraliaAustralia.

The diamondback moth,Plutella xylostella (L.),uses sulfatases (SULF)to counteract the glucosinolate-myrosinase defensive system that cruciferous plants have evolved to deter insect *** activity is regulated by post-translational modi- fication of a cysteine residue by sulfatase modifying factor 1(SUMF1).We identified 12 SULF genes (PxylSulfs)and two SUMF1 genes (PxylSumfls)in the *** genome. Phylogenetic analysis of SULFs and SUMFs from ***,Bombyx mori,Manduca sexta,Heliconius melpomene,Danaus plexippus,Drosophila melanogaster,Tetranychus urticae and Homo sapiens showed that the SULFs were clustered into five groups,and the SUMFs could be divided into two *** of the expression of PxylSulfs and Pxyl Sumfs by RNA-seq and by quantitative real-time polymerase chain reaction showed that two glucosinolate sulfatase genes (GSS),PxylSulf2and PxylSulf3,were primarily expressed in the midgut of 3rd-and 4th-instar ***,expression of sulfatases PxylSulf2, PxylSulf3 and PxylSulf4 were correlated with expression of the sulfatases modifying fac tor *** findings from this study provide new insights into the structure and expression of SUMF1and PxylSulf genes that are considered to be key factors for the evolutionary success *** as a specialist herbivore of cruciferous plants.

关键词： evolutionary arms race glucosinolate detoxification glucosinolate sulfatase phylogenetie analysis transcriptome analysis

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Cell Iines from diamondback moth exhibiting differential susceptibility to baculovirus infection and expressing midgut genes

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Insect Science 2019年第2期26卷 251-262页

作者： Xiao-Li Ma Wei-Yi He Ping Wang Min-Sheng You State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry University Fuzhou China Fujian -Taiwan Joint Centre for Ecological Control of Crop Pests Fujian Agriculture and Forestry University Fuzhou China Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops Ministry of Agriculture Fujian Agriculture and Forestry University Fuzhou China Institute of Applied Ecology Fujian Agriculture and Forestry University Fuzhou China Department of Entomology Cornell University Geneva NY USA

Abstract Six new cell lines were established from embryonic tissues of the diamondback moth, Plutella xylostella (L.). The cell lines showed differential characteristics, including growth in attachment or in suspension, susceptibility to a baculovirus infection and expression of genes involved in the glucosinolate detoxification pathway in R xylostella larvae. Five of the cell lines grew attached to the culture flask and one cell line grew unattached as a suspension cell line. The cell lines had population doubling times ranging from IS to 23 h. Among five of the P. xylostella cell lines examined for infection of a nucleopolyhe. drovirus from Autographa californica, AcMNPV four cell lines were highly susceptible to AcMNPV infection, but one was only semi-permissive to AcMNPV infection. The production of two recombinant proteins, a β-galactosidase of bacterial origin and a secreted alkaline phosphatase of eukaryotic origin, in the R xylostella cell lines was examined in comparison with that in the cell line Sf9 which is commonly used for recombinant protein production. In the P. xylostella cell lines, expression of three important midgut genes involved in the glucosinolate detoxification pathway, including the glucosinolate sulfatase genes GSS1 and GSS2 and the sulfatase modifying factor gene SUMF1、was detected. The R xylostella cell lines developed in this study could be useful in in vitro research systems for studying insec-virus interactions and complex molecular mechanisms in glucosinolate detoxification and insect-plant interactions.

关键词： AcMNPV cell lines glucosinolate sulfatase (GSS) Plutella xylostella PxGV sulfatase modifying factor 1 (SUMF1)

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Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches

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World Journal of Psychiatry 2017年第2期7卷 77-88页

作者： William Davies Medical Research Council Centre for Neuro-psychiatric Genetics and Genomics and Division of Psychological Medicine and Clinical Neurosciences School of Medicine Cardiff University School of Psychology Cardiff University Neuroscience and Mental Health Research Institute Cardiff University

Postpartum psychosis is a severe psychiatric condition which affects 1-2 of every 1000 mothers shortly after childbirth. Whilst there is convincing evidence that the condition is precipitated by a complex combination of biological and environmental factors, as yet the pathophysiological mechanisms remain extremely poorly defined. Here, I critically review approaches that have been, or are being, employed to identify and characterise such mechanisms; I also review a recent animal model approach, and describe a novel biological risk model that it suggests. Clarification of biological risk mechanisms underlying disorder risk should permit the identification of relevant predictive biomarkers which will ensure that "at risk" subjects receive prompt clinical intervention if required.

关键词： CCN3 Immune system Steroid sulfatase Nephroblastoma-overexpressed Mouse Animal model Risk factor

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Genetics and pathophysiology of mammalian sulfate biology

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Journal of Genetics and Genomics 2017年第1期44卷 7-20页

作者： Rachel Langford Elizabeth Hurrion Paul A. Dawson Mater Research Institute University of Queensland Woolloongabba 4102 Queensland Australia Mater Mothers' Hospital South Brisbane 4101 Queensland Australia

Nutrient sulfate is essential for numerous physiological functions in mammalian growth and development. Accordingly, disruptions to any of the molecular processes that maintain the required biological ratio of sulfonated and unconjugated substrates are likely to have detrimental consequences for mammalian physiology. Molecular processes of sulfate biology can be broadly grouped into four categories： firstly, intracellular sulfate levels are maintained by intermediary metabolism and sulfate transporters that mediate the transfer of sulfate across the plasma membrane; secondly, sulfate is converted to 3＇-phosphoadenosine 5＇-phosphosulfate （PAPS）, which is the universal sulfonate donor for all sulfonation reactions; thirdly, sulfotransferases mediate the intracellular sulfonation of endogenous and exogenous substrates; fourthly, sulfate is removed from substrates via sulfatases. From the literature, we curated 91 human genes that encode all known sulfate transporters, enzymes in pathways of sulfate generation, PAPS synthetases and transporters, sulfotransferases and sulfatases, with a focus on genes that are linked to human and animal pathophysiology. The predominant clinical features linked to these genes include neurological dysfunction, skeletal dysplasias, reduced fecundity and reproduction, and cardiovascular pathologies. Collectively, this review provides reference information for genetic investigations of perturbed mammalian sulfate biology.

关键词： Sulfate Pathogenetics Transport Sulfotransferase sulfatase PAPS

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X linked recessive ichthyosis: Current concepts

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World Journal of Dermatology 2015年第3期4卷 129-134页

作者： Jaime Toral-López Luz María González-Huerta Sergio A Cuevas-Covarrubias Departamento de Genética Médica Centro Médico Ecatepec Instituto de Seguridad Social del Estado de México y Municipios Ecatepec Estado de México CP 55000 México Departamento de Genética Médica Hospital General de México/Facultad de Medicina Universidad Nacional Autónoma de México Ciudad de México CP 06726 México

In the present review, we describe the most importantaspects of the X-linked ichthyosis(XLI) and make a compilation of the some historic details of the disease. The aim of the present study is an update of the XLI. Historical, clinical, epidemiological, and molecular aspects are described through the text. Recessive XLI is a relatively common genodermatosis affecting different ethnic groups. With a high spectrum of the clinical manifestations due to environmental factors, the disease has a genetic heterogeneity that goes from a point mutation to a large deletion involving several genes to produce a contiguous gene syndrome. Most XLI patients harbor complete STS gene deletion and flanked sequences; seven intragenic deletions and 14 point mutations with a complete loss of the steroid sulfatase activity have been reported worldwide. In this study, we review current knowledge about the disease.

关键词： STS gene X-linked ichthyosis Steroid sulfatase Gene deletion Contiguous gene syndrome Genodermatosis

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