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Chemical components of ambient particulate air pollution affecting suicides in Thailand

Emerging Contaminants 2022年第1期8卷 304-309页

作者： Kriangsak Jenwitheesuk Surapol Virasiri Kamonwan Jenwitheesuk Udomlack Peansukwech Suwanna Arunpongpaisal Nuttakorn Nampathong Faculty of Medicine Khon Kaen UniversityKhon KaenThailand CKDnet Khon Kaen UniversityKhon KaenThailand Khon Kaen Rajanakarindra Psychiatric Hospital Khon KaenThailand

This research studied correlation between suicide risks and chemical components of particulate matter in *** employed satellite data on atmospheric particulate *** for correlation between data on chemical components of particulate matterda type of accumulated pollution in Thailand from 2010 to 2017dand suicidal incidents in *** methodologies consisted of Bayesian hierarchical spatiotemporal model and the Poisson log-linear model,which referred to the NASA database;aerosol diagnostics model,Modern-Era Retrospective Analysis for Research and Applications,Version 2(MERRA-2);and database from the Bureau of Policy and Strategy Ministry of Public Health,Thailand.A total of 4,756 patients selected for this study accounted for annual suicide rate of 7.16 per 100,000 *** in Thailand are related to chemical components of particulate *** research thus found that every 1 mg/m^(3)increase of dust-PM2.5,only PM2.5 was related to the risks of suicide(which increased for approximately 63.5%).Black carbon,Organic carbon,and sulfate,however,had no statistically significant *** of atmospheric accumulated dust-PM2.5 correlated to increase in suicide risks,with statistical significance.

关键词： suicides Air pollution Dust-PM2.5 Black carbon Organic carbon Sulfate MERRA-2

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Cerbera are coastal trees with promising anticancer properties but lethal toxicity： A short review

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Journal of Chinese Pharmaceutical Sciences 2016年第3期25卷 161-169页

作者： Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan Shigeyuki Baba Mio Kezuka Faculty of Applied Sciences UCSI University 56000 Cheras Kuala Lumpur Malaysia School of Science Monash University Sunway 46150 Petaling Jaya Selangor Malaysia Secretariat International Society for Mangrove Ecosystems c/o Faculty of Agriculture University of the Ryukyus Okinawa903-0129 Japan

In this short review, the current knowledge on the chemical constituents and anticancer properties of Cerbera odollam and Cerbera manghas is updated with some description of their botany and uses. Although these two closely-related coastal tree species have overlapping geographical distribution, they can be distinguished by the eye colour of flowers and the shape of fruits. Chemical constituents of C. odollam and C. manghas include lignans, iridoids, terpenoids, cardiac glycosides(cardenolides), flavonoids, phenolic acids and steroids. Cardiac glycosides of cerberin, dehydrocerberin, neriifolin, tanghinin, deacetyltanghinin and tanghinigenin possess promising anticancer properties with apoptotic activities. However, these cardiac glycosides are also cardiotoxic. Fatal cases of suicides by ingesting Cerbera fruits or seeds have been reported in India and Sri Lanka. In two suicide cases, one in Taiwan and another in the United States, the patients recovered completely. In New Caledonia, four death-threatening cases of poisoning(two were fatal) occurred through consuming toxic coconut crabs. Taken together, both C. odollam and C. manghas are endowed with cardiac glycosides, which have useful pharmacological properties but lethal toxicity.

关键词： Sea mango Phytochemistry Pharmacology Cytotoxic Apoptosis suicides

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