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Dissecting the Contributing Role of Divergent adipose tissue to Multidimensional Frailty in Cirrhosis

Journal of Clinical and Translational Hepatology 2023年第1期11卷 58-66页

作者： Lihong Mao Chaoqun Li Xiaoyu Wang Mingyu Sun Yifan Li Zihan Yu Binxin Cui Gaoyue Guo Wanting Yang Yangyang Hui Xiaofei Fan Jie Zhang Kui Jiang Chao Sun Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjinChina Tianjin Institute of Digestive Disease Tianjin Medical University General HospitalTianjinChina Department of Internal Medicine Tianjin Hexi HospitalTianjinChina Department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjinChina

Background and Aims:Emerging evidence has demonstrated that abnormal body composition may potentiate the development of frailty,whereas little work focuses on the role of divergent adipose ***,we aimed to determine the potential contribution of adipose tissue distribution to multidimensional frailty in decompensated ***:We conducted a retrospective cohort *** adipose tissues were assessed by computed tomography-derived subcutaneous adipose tissue index(SATI),visceral adipose tissue index(VATI)and total adipose tissue index(TATI),*** was identified by our validated self-reported Frailty *** binary logistic models incorporating different covariates were established to assess the relationship between adipose tissue distribution and ***:The study cohort comprised 245 cirrhotic patients with 45.3%being *** median Frailty index,body mass index(BMI)and model for end-stage liver disease(MELD)score were 0.11,24.3 kg/m2 and 8.9 points,*** both men and women,patients who were frail exhibited lower levels of SATI in comparison with nonfrail *** inversely correlated with Frailty index in the entire cohort(rs=−0.1361,p=0.0332).Furthermore,SATI or TATI was independently associated with frail phenotype in several multiple logistic regression models adjusting for age,BMI,presence of ascites,sodium,Child-Pugh class or MELD score in ***:In the context of decompensated cirrhosis,low SATI and concomitant TATI were associated with higher risk of being *** findings highlight the importance to further apply tissue-specific tools of body composition in place of crude metric like BMI.

关键词： Frailty adipose tissue Liver cirrhosis subcutaneous adipose tissue index

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