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Acupotomy ameliorates subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis by regulating bone morphogenetic protein 2-Smad1 pathway

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中医杂志:英文版 2023年第4期43卷 734-743页

作者： Chen Xilin GUO Yan LU Juan QIN Luxue HU Tingyao ZENG Xin WANG Xinyue ZHANG Anran ZHUANG Yuxin ZHONG Honggang GUO Changqing School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Acupuncture and Moxibustion Department Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical UniversityBeijing 100010China Shenzhen Hospital of Southern Medical University Shenzhen 518000China Institute of bone Injury China Academy of Chinese Medical SciencesBeijing 100010China

OBJECTIVE:To investigate the effects of acupotomy on the subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis(KOA).METHODS:The rabbits were divided into blank control,model,acupotomy and electroacupuncture(EA)groups,with 12 rabbits in *** Videman's method was used to prepare KOA *** acupotomy and EA group were given indicated intervention for 3 *** behavior of rabbits in each group was ***,cartilage–subchondral bone units were obtained and morphological changes were observed by optical microscope and micro computed *** test was used to detect the mechanical properties of subchondral bone,Western blot and real-time polymerase chain reaction(RT-PCR)were applied to detect the expression of bone morphogenetic protein 2-Smad1(BMP2-Smad1)pathway in subchondral ***:Compared with the control group,rabbits in the KOA group showed lameness,knee pain,and cartilage degradation;the subchondral bone showed active resorption,the mechanical properties decreased significantly and the BMP2-Smad1 pathway downregulated *** acupotomy and EA intervention could increase the thickness of trabecular bone(***),the bone volume fraction(BV/TV)and the thickness of subchondral bone plate,reduce the separation of trabecular bone(***),improve the maximum load and elastic modulus of subchondral bone,and effectively delay cartilage degeneration in KOA *** process may be achieved through upregulation the related proteins of BMP2-Smad1 *** maximum load and elastic modulus of subchondral bone in the acupotomy group were slightly better than those in the EA ***:Acupotomy could effectively protect cartilage by inhibiting abnormal bone resorption and improving mechanical properties of subchondral bone thorough the related proteins of BMP2-Smad1 pathway in KOA rabbits.

关键词： acupuncture therapy osteoarthritis knee subchondral bone mechanical properties bone morphogenetic protein 2 Smad1 protein

Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-κB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method

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Journal of Traditional Chinese Medicine 2022年第3期42卷 389-399页

作者： QIN Luxue GUO Changqing ZHAO Ruili WANG Tong WANG Junmei GUO Yan ZHANG Wei HU Tingyao CHEN Xilin ZHANG Qian ZHANG Dian XU Yue School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China the First People's Hospital of Dongcheng District Beijing 100050China Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China the Third Affiliated Hospital of Beijing Universality of Chinese Medicine Beijing 100029China

OBJECTIVE:To investigate the effects of acupotomy on inhibiting abnormal formation of subchondral bone in rabbits with knee osteoarthritis(KOA).METHODS:A total of 24 New Zealand rabbits were randomly divided into four groups of 6 rabbits each[control,model,electroacupuncture(EA)and acupotomy].Eighteen KOA model rabbits were established using a modified Videman *** in EA and acupotomy groups received the intervention for 3 ***,the cartilage and subchondral bone unit were obtained and the histomorphological changes were ***(OPG)and receptor activator of nuclear factor-κB ligand(RANKL)in subchondral bone were evaluated by Western blotting,real-time polymerase chain reaction and ***:Compared with the model group,both the acupotomy and EA groups showed a significant decrease in the Lequesne index(both Psubchondral bone plate in EA and acupotomy groups were decreased(both Pbone volume(BV/TV),protein and relative expression of OPG and the ratio of OPG/RANKL in the subchondral bone of acupotomy group were decreased statistically significant,while these parameters were not significantly changed in the EA group compared with the model ***:In the rabbit model of KOA,acupotomy inhibits aberrant formation of subchondral bone by suppressing OPG/RANKL ratio as a potential therapy for KOA.

关键词： acupuncture therapy osteogenesis osteoarthritis,knee subchondral bone

subchondral bone as a novel target for regenerative therapy of osteochondritis dissecans:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3623-3630页

作者： Sheng-Yang Zhang Hui-Hui Xu Miao-Miao Xiao Jing-Jing Zhang Qiang Mao Bang-Jian He Pei-Jian Tong Institute of Orthopedics and Traumatology The First College of Clinical MedicineZhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina The First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Osteochondritis dissecans(OCD)is a rare disease of unclear cause characterized by subchondral bone damage and overlying cartilage *** current report presents the results of subchondral bone as a novel target for implantation of peripheral blood stem cells(PBSCs)in the treatment of *** SUMMARY A 16-year-old patient diagnosed with OCD underwent subchondral bone implantation of *** months later,the patient's visual analog scale scores,Western Ontario and McMaster University osteoarthritis index,and whole-organ magnetic resonance imaging score improved significantly,and regeneration of cartilage and subchondral bone was observed on magnetic resonance *** This is the first case of OCD treated with subchondral bone as an implantation target of PBSCs,which highlights the importance of subchondral bone for cartilage *** treatment could be a potential option for articular cartilage and subchondral bone recovery in OCD.

关键词： Osteochondritis dissecans Peripheral blood stem cells subchondral bone Cartilage Case report

Effects of Structural Changes in subchondral bone on Articular Cartilage in a Beagle Dog Model

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Biomedical and Environmental Sciences 2017年第3期30卷 194-203页

作者： YAN Dong LIU Tong Xi LIU Bao Yue WANG Ling QIAN Zhan Hua CHENG Xiao Guang LI Kun Cheng Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Radiology Beijing Jishuitan HospitalFourth Clinical Hospital of Peking University Health ScienceCenterBeijing 100035China Department of Pathology Beijing Jishuitan HospitalFourth Clinical Hospital of Peking University Health Science CenterBeijing 100035China

Objective Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. Methods Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group （n = 12） and a bone cement group （n = 12）. Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side. The T2 value for articular cartilage at the medial tibial plateau was measured at postoperative weeks 4, 8, 16, and 24. The articular cartilage specimens were stained with hematoxylin and eosin, and evaluated using the Mankin score. Results There was a statistically significant difference （P 〈 0.05） in Mankin score between the bone defect group and the cement group at postoperative weeks 16 and 24. There was a statistically significant difference in the T2 values between the bone defect group and its sham group （P 〈 0.05） from week 8, and between the cement group and its sham group （P 〈 0.05） from week 16. There was significant difference in T2 values between the two experimental groups at postoperative week 24 （P 〈 0.01）. The T2 value for articular cartilage was positively correlated with the Mankin score （ρ = 0.758, P 〈 0.01）. Conclusion Structural changes in subchondral bone can lead to degeneration of the adjacent articular cartilage. Defects in subchondral bone cause more severe degeneration of cartilage than subchondral bone filled with cement. The T2 value for articular cartilage increases with the extent of degeneration. MR T2-mapping images and the T2 value for articular cartilage can indicate earlycartilage degeneration.

关键词： MR T2-mapping subchondral bone Articular cartilage Degeneration

Observation on the Clinical Effect of Needle Knife Release Combined with Microporous Decompression in subchondral bone Marrow Edema Area for Treatment of Knee Osteoarthritis

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World Journal of Integrated Traditional and Western Medicine 2021年第6期7卷 45-51页

作者：胡永召徐迎锋张健阮志华徐通赵腾飞韩柄秋张义浦 Kaifeng Hospital of Traditional Chinese Medicine Henan ProvinceKaifeng 475000China The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou 450008China

Objective:To observe the curative effect of release with needle knife combined with microporous decompression in bone marrow edema area of subchndral bone for treatment of knee ***:From March 2019 to March 2020,66 patients with knee osteoarthritis were selected as the research objects,and divided into treatment group and control group according to random nuber *** treatment group was treated with release with needle knife combined with microporous decompression in bone marrow edema area,while the control group was treated with release with needle *** analogue scale(VAS),the Western Ontario and Mc Master University composite index(WOMCA)and inflammatory factors were used to evaluate the curative effect of patients before treatment and after ***:The VAS scores of knee pain in both groups decreased after *** treatment group was lower than the control *** WOMAC scores of both groups were decreased significantly after treatment,and then gradually decreased with *** WOMAC scroes of the treatment group were lower than those of the control group after treatment,and there was an interactive effect on time ***:Release with needle knife combined with microporous decompression in bone marrow edema area of subchondral bone has good curative effect in the treatment of knee osteoarthritis;it can relieve the pain of patients,improve the function of joint,reduce inlfammatory reaction,and then delay the pathological progress of KOA,which is worthy of clinical promotion.

关键词： Small needle knife subchondral bone bone marrow edema area Microporous decompression Knee osteoarthrosis

Distribution of mechanical strain in equine distal metacarpal subchondral bone:A microCT-based finite element model

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Medicine in Novel Technology and Devices 2020年第2期6卷 19-25页

作者： Fatemeh Malekipour R.Chris Whitton Peter Vee-Sin Lee Department of Biomedical Engineering Melbourne School of EngineeringUniversity of MelbourneAustralia U-Vet Equine Centre Melbourne Veterinary SchoolFaculty of Veterinary and Agricultural SciencesUniversity of MelbourneMelbourneAustralia

Microdamage accumulation and adaptation of subchondral bone subjected to intensive cyclic loading are important processes associated with catastrophic bone failure,and joint degeneration in athletic humans and *** the tissue-level,they lead to a spatial variation in bone tissue mineral density(TMD)which affects the response of the bone to mechanical *** the spatial distribution of mechanical load within the subchondral bone is critical for understanding the mechanism of the joint ***,a gradient of TMD and mechanical properties has been reported under unconfined compression in osteochondral *** the present study,we used micro computed tomography(μCT)-based finite element(FE)models of cartilage-bone to investigate the gradient of strain in the subchondral bone(SCB)from the third metacarpal(MC3)condyle of racehorses under simulated in situ ***-destructive mechanical testing of specimens under high-rate compression provided the apparent-level modulus of *** models were analysed using unconfined and confined boundary *** FE-predicted apparent-level gradient of modulus across the SCB thickness correlated well with the experimental results(R^(2)=0.72,pbone interface)under the simulated in-situ compression through articular *** findings of this study provide an estimation for the spatial distribution of mechanical strain within SCB in-situ in the presence of heterogeneous bone tissue which is commonly observed in joints subjected to intensive cyclic loading.

关键词： subchondral bone μFE modelling Impact load Cartilage-bone Tissue mineral density Heterogeneity