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subcellular distribution of prohibitin 1 in rat liver during liver regeneration and its cellular implication

World Journal of Hepatology 2024年第1期16卷 65-74页

作者： Qing-Ju Sun Tao Liu Department of Clinical Laboratory Navy No.971 HospitalQingdao 266072Shandong ProvinceChina Department of Infectious Diseases Navy No.971 HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND The function of prohibitin 1(Phb1)during liver regeneration(LR)remains relatively *** previous research identified downregulation of Phb1 in rat liver mitochondria 24 h after 70%partial hepatectomy(PHx),as determined by subcellular proteomic *** To investigate the potential role of Phb1 during *** We examined changes in Phb1 mRNA and protein levels,subcellular distribution,and abundance in rat liver during LR following 70%*** also evaluated mitochondrial changes and apoptosis using electron microscopy and flow ***-interference-mediated knockdown of Phb1(PHBi)was performed in BRL-3A *** Compared with sham-operation control groups,Phb1 mRNA and protein levels in 70%PHx test groups were downregulated at 24 h,then upregulated at 72 and 168 ***1 was mainly located in mitochondria,showed a reduced abundance at 24 h,significantly increased at 72 h,and almost recovered to normal at 168 ***1 was also present in nuclei,with continuous increase in abundance observed 72 and 168 h after 70%*** altered ultrastructure and reduced mass of mitochondria during LR had almost completely recovered to normal at 168 *** in BRL-3A cells resulted in increased S-phase entry,a higher number of apoptotic cells,and disruption of mitochondrial membrane *** Phb1 may contribute to maintaining mitochondrial stability and could play a role in regulating cell proliferation and apoptosis of rat liver cells during LR.

关键词： Prohibitin 1 Liver regeneration subcellular proteomic analysis Mitochondrial stability Cell proliferation

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