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Evaluation on Effectiveness and Safety of Chinese Herbs inTreatment of sub-health: A Systematic Review andMeta-Analysis of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2019年第6期25卷 471-480页

作者： ZHAO Jun LIAO Xing ZHAO Hui LI Zhi-geng WANG Nan-yue WANG Li-min China Academy of Chinese Medical Science Beijing (100700) China Beijing University of Chinese Medicine Beijing (100029) China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Science Beijing (100700) China Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences Beijing (100700) China Experimental Research Center China Academy of Chinese Medical Sciences Beijing (100700) China

Objective: To evaluate the effectiveness and safety of Chinese herbs in the treatment of sub-health systematical y. Methods: Nine databases were systematicaly and extensively searched to col ect randomized control ed trials(RCTs) about Chinese herbs in the treatment of sub-health. The outcomes included overal effective rate, main symptoms, quality of life, etc. Literature screening, data extraction and quality assessment were conducted according to Cochrane Handbook 5.1. Meta-analysis was conducted to the included literature with Review Manager ***: Seventy-two studies involving 9,296 patients with sub-health were included with 4,908 patients in experimental groups and 4,387 patients in control groups. The overal quality of included clinical research was not high. In the aspect of improving overall effective rate, relieving main symptoms, Pittsburgh sleep quality index(PSQI) score, Athens Insomnia Scale(AIS) score, Fatigue Scale-14(FS-14), Cornel Medical Index(CMI) score and discontinuation rate, the effects of experimental groups were better than that of control groups. According to available research reports, adverse reactions in Chinese herb groups were mainly mild gastrointestinal symptoms, which did not affect the ***: Chinese herbs have a curative effect in the treatment of sub-health. However, there are no clear criteria for diagnosis and curative effectiveness judgment global y, which would affect the accuracy of curative effect evaluation.

关键词： sub-health randomized controlled trials Chinese medicine systematic review

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Effect of moxibustion on the nailfold microcirculation of young and middle-aged people in sub-health status

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World Journal of Acupuncture-Moxibustion 2017年第4期27卷 1-7页

作者：田岳凤翟春涛高海宁陈猛王军山西中医药大学针灸推拿学院山西太原030024 湖南中医药大学湖南长沙410208

Objective To explore the mechanism of moxibustion for people in sub-health status. Methods Thirty-nine young and middle-aged sub-health volunteers were enrolled, including 13 males and 26 females. Mild moxibustion was adopted, and Shenque （神阙 CV 8）, Guanyuan （关元 CV 4）, Zusanli （足三里 ST 36, bilateral）, Pish0 （脾俞 BL 20, bilateral） and Shenshu （肾俞 BL 23, bilateral） were selected. The moxibustion was performed once every other day, 20 min at each time, and moxibustion for ten times was needed. The changes in morphology, flow velocity and pefiloop of nailfold microcirculation were detected by adopting microcirculation detector before moxibustion, after moxibustion for three times, six times, ten times, and on the 15th day after moxibustion, respectively. Results After moxibustion, the abnormal blood capillary morphology of microcirculation gradually turned into normal pattern along with the increase of the number of times of moxibustion, according to the comparison of the number of capillary loop, the diameter of input limb, the diameter of output limb/the diameter of input limb, flow pattern integral, pefiloop integral and total integral with those before moxibustion, the differences were all statistically significant （all P〈0.01）. Conclusion Moxibustion changs the microcirculation of nailfold of body, improves the blood flow pattern, makes the pefiloop status clear, accelerats the blood flow and increases the microcirculation perfusion amount, thus regulating the sub- health status of human body.

关键词： Mild moxibustion sub-health nail fold microcirculation

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Study of Zero-Inflated Regression Models in a Large-Scale Population Survey of sub-health Status and Its Influencing Factors

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Chinese Medical Sciences Journal 2017年第4期32卷 218-225页

作者： Tao Xu Guangjin Zhu Shaomei Han Department of Epidemiology and Statistics Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing 100005 China Department of physiopathology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing 100005 China

Objective sub-health status has progressively gained more attention from both medical professionals and the publics. Treating the number of sub-health symptoms as count data rather than dichotomous data helps to completely and accurately analyze findings in sub-healthy population. This study aims to compare the goodness of fit for count outcome models to identify the optimum model for sub-health *** The sample of the study derived from a large-scale population survey on physiological and psychological constants from 2007 to 2011 in 4 provinces and 2 autonomous regions in China. We constructed four count outcome models using SAS: Poisson model, negative binomial (NB) model, zero-inflated Poisson (ZIP) model and zero-inflated negative binomial (ZINB) model. The number of sub-health symptoms was used as the main outcome measure. The alpha dispersion parameter and O test were used to identify over-dispersed data, and Vuong test was used to evaluate the excessive zero count. The goodness of fit of regression models were determined by predictive probability curves and statistics of likelihood ratio *** Of all 78 307 respondents, 38.53% reported no sub-health symptoms. The mean number of sub-health symptoms was 2.98, and the standard deviation was 3.72. The statistic O in over-dispersion test was 720.995 (Psub-health study. ZINB model had the largest log likelihood (-167 519), the smallest Akaike’s Information Criterion coefficient (335 112) and the smallest Bayesian information criterion coefficient (335455),indicating its best goodness of fit. The predictive probabilities for most counts in ZINB model fitted the observed counts best. The logit section of ZINB model analysis showed that age, sex, occupation, smoking, alcohol drinking, ethn

关键词： zero-inflated negative binomial regression sub-health population survey

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Progress of research on massage therapy for sub-health conditions

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TMR Non-Drug Therapy 2019年第1期2卷 20-26页

作者： Bo-Yang Pan Tian Chen Long-Ming Lei Liuzhou Hospital of Traditional Chinese Medicine Liuzhou China The first Affiliated Hospital of Guangxi University of Traditional Chinese Medicine Nanning China

sub-health state is a kind of low-quality state between health and disease, and will lead to disease if not intervened in time. As one of the external treatment options in traditional Chinese medicine (TCM), massage therapy has achieved an ideal curative effect in the treatment of the sub-health state. This paper summarizes the articles on massage treatment for the treatment of patients in the sub-health state from the past decade. It mainly includes the current understanding of sub-health, treatment ideas and specific methods, as well as clinical classification of treatment modalities. From the perspective of treatment ideas and specific methods, most massage therapies are performed under the guidance of the holistic concept of TCM, and the concept of treatment based on syndrome differentiation (four diagnostic methods of TCM: inspection, auscultation, inquiry, and palpation). In this treatment, not only are the therapeutic functions of meridians and acupoints emphasized, but the selection of the therapeutic time is also performed according to the "Ziwuliuzhu" and the "Lingguibafa"(the acupuncture method based on time in ancient China). According to the different clinical symptoms of sub-health, it can be divided into three types: physical sub-health, psychological sub-health, and social adaptive sub-health. Massage therapy eliminates pain, relieves physical fatigue, and has a good therapeutic effect on physical sub-health. It can alleviate anxiety and depression, promote psychosomatic pleasure of patients, and has a satisfactory regulatory effect on the psychological sub-health symptoms. However, basic research on using modern medical theories and the means to explain its mechanism of action is relatively weak. Therefore, only constantly improving the quality of clinical observation and strengthening basic research can provide more and better evidence for the clinical application of massage therapy in treating the symptoms of the sub-health status.

关键词： Massage therapy TCM sub-health Review

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Concepts of body constitution, health and sub-health from traditional Chinese medicine perspective

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World Journal of Translational Medicine 2013年第3期2卷 56-66页

作者： Rose YP Chan Wai Tong Chien School of Nursing Faculty of Health and Social Sciences The Hong Kong Polytechnic University

This paper described and discussed the important literature and ideas about the concepts, types and measurement of body constitution, in terms of healthy,sub-healthy and disease status. In view of traditional Chinese medicine, ‘‘healthy" state is a status of relative balance of Yin and Yang to keep our bodily homeostasis. If there are significant physical and/or psychological stressors, such as loss of a beloved one and failure in study or work, the body can no longer keep its own bodily condition balanced and subsequently enter a state of ‘‘sub-health"(sub-optimal health).‘‘unhealthy" body constitution such as ‘‘Dampnessheat", ‘‘Cold-dampness" and ‘‘Heat- or Cold- dryness"with a subnormal body temperature and humidity and clinical manifestations such as insomnia, malaise and overweight will be presented. Immediate, appropriate strategies such as modification of life-style and seeking medical treatment can prevent evolution of an ***, the body will enter a disease status with a‘‘pathological" body constitution of ‘‘Yin or Yang deficiency'', ‘‘Blood-stasis" and/or ‘‘Phlegm-dampness". To be complimentary with health promotion and disease prevention in Western medicine, understanding about an individual's body constitution, together with itsdeterminants(e.g., healthy eating and lifestyle behaviors), can contribute to a more proactive, holistic and individualized healthcare.

关键词： Body constitution health sub-health Disease Traditional Chinese medicine

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Clinical Efficacy of Sedative Cataplasm for Insomnia Patients with sub-health

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Medicinal Plant 2021年第2期12卷 67-69页

作者： Xiaoxue GONG Qin GONG Xi WANG Shiyan Hospital of Traditional Chinese Medicine Shiyan 442000 China Shiyan Taihe Hospital/Affiliated Hospital of Hubei University of Medicine Shiyan 442000 China

[Objectives]This study aimed to observe the clinical efficacy of sedative cataplasm in the treatment of insomnia patients with sub-health.[Methods]A total of 90 insomnia patients with sub-health were randomly and evenly divided into treatment group and control *** patients in the control group were given Bozi Yangxin pills orally,and those in the treatment group were treated with sedative cataplasm on Shenjue *** treatment duration was 4 *** Pittsburgh Sleep Quality Index(PSQI)was used to evaluate clinical efficacy.[Results]The overall efficacy of the treatment group and control group was 91.1%and 77.1%,respectively,and the difference between the two was significant(Psub-healthy insomnia patients.

关键词： sub-health Insomnia Sedative cataplasm Clinical observation

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Relationship Research between the Chinese Medicine Constitution and sub-health

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Engineering（科研） 2013年第10期5卷 429-432页

作者： Xiufeng Liu Bo Xu Zhenhu Chen School of Medical Information Engineering Guangzhou University of Chinese Medicine Guangzhou China

With further development of the bio-psycho-social medical model, people began to re-examine the knowledge of disease and health. The concept of sub-health has also been proposed in western medicine. Because of the lack of a specific standard, it is difficult to make clinical diagnosis and treatments for sub-health. Chinese medicine constitution theory has been widely accepted in China, and has a set of executable standards. This paper puts forward a new research method that connects the sub-health in western medicine and Chinese medicine constitution theory together. The potential relationships and influences between Chinese medicine constitution theory and sub-health were analyzed and key content and research progress were discussed. The research method in this paper will provide new ideas for sub-health research.

关键词： Chinese Medicine Constitution sub-health Relationship

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A research on the composing of sub-health people’s hygienic gymnastics

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International Journal of Technology Management 2016年第6期 63-65页

作者： Jiao Lizhi Sports College Hulun Buir College Inner Mongolia 021008

according to statistics, 70 percent of Chinese people are in sub-health, so the health care for them should be payed more attention. In recent years, researches on sub-health people has increased and the classifi cation, diagnose for sub-health people’s current situation has entered an area of researching. Among them, the research of sub-health people’s infl uence on society stands out, because the occupational group is tightly related to the promotion of social economic development and stability. Hygienic gymnastics will help to improve sub-health situation and it still need to conduct relatively composing and completing. In this paper, questionnaire method and literature method are used to carry out investigation and analysis on sub-health people and therefore, the hygienic gymnastics for sub-health improving is composed and summarized.

关键词： sub-health hygienic gymnastics composing thinking method

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Structural and functional characteristics of microbiota in oropharynx of sub-healthy children with gastrointestinal heat retention syndrome differentiated by traditional Chinese medicine

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 230-236页

作者： Jianhua Zhen He Yu Xiaofei Li Fei Dong Zi'an Zheng Xueyan Ma Yuxiang Wan Tiegang Liu Lu Fan Xiaohong Gu School of Life Sciences Beijing University of Chinese MedicineBeijing102488China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Department of Traditional Chinese Medicine People's Hospital of Laoling CountyLaoling253600China Institute of Chinese Medicine Epidemic Disease Beijing University of Chinese MedicineBeijing102488China School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang550025China Department of Acupuncture and Mini-invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing100029China Student Affairs Department Beijing University of Chinese MedicineBeijing102488China

Objective:To explore the structural and functional characteristics of microbiota in oropharynx of subhealthy children with gastrointestinal heat retention syndrome(GHRS)differentiated by traditional Chinese medicine,and screen the biometric operational taxonomic units(OTUs)to assist the clinical ***:We recruited children according to the“GHRS diagnostic scale”,collected their oropharyngeal swabs,and sequenced the 16 SrDNA V4 *** described the bacterial structure with alpha-indexes,beta-distances,and relative abundances;moreover,we screened the differential genera/OTUs with Wilcoxon rank-sum test,Metagenome Seq analysis,and linear discriminant analysis effect size(LEf Se)analysis,in which biometric OTUs were selected to construct the receiver operating characteristic curve to verify the diagnostic *** bacterial function was predicted with Kyoto Encyclopedia of Genes and Genomes pathways according to 16S rDNA gene by using Phylogenetic Investigation of Communities by Reconstruction of Unobserved ***:The study population was composed of 10 children with GHRS and 10 healthy control *** children were more likely to overeat(gluttony,P=.033).Alpha-indexes,such as Sobs,abundancebased coverage estimator,Bootstrap,and Qstat,were significantly higher in the GHRS group,while betadistances did not exhibit any significant intergroup *** were 9 differently distributed nonpredominant genera between the groups in Wilcoxon rank-sum test,as well as 13 non-predominant genera in Metagenome Seq analysis and 3 non-predominant OTUs in LEfSe ***44 and OTU196 were used to construct the receiver operating characteristic curve,and the area under curve was *** functions showed that pathways related to oxidative phosphorylation and carbon metabolism were enriched in healthy control samples,while the pathway related to renin secretion was remarkably enriched in GHRS ***:Unique oropharyngeal microbial s

关键词： sub-health Gastrointestinal heat retention syndrome Traditional Chinese medicine Microbiota in oropharynx 16S rDNA sequencing Children Differential genus Biometric operational taxonomic units

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Evaluation of the health Status of Six Volunteers from the Mars 500 Project Using Pulse Analysis

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Chinese Journal of Integrative Medicine 2017年第8期23卷 574-580页

作者： SHI Hong-zhi FAN Quan-chun GAO Jian-yi LIU Jun-lian BAI Gui-e MI Tao ZHAO Shuang LIU Yu XU Dong GUO Zhi-feng LI Yong-zhi State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center Beijing 100094 China

Objective：To comprehensively evaluate the health status of 6 volunteers from the Mars 500Project through analyzing their pulse graphs and determining the changes in cardiovascular function,degree of fatigue and autonomic nervous ***：Six volunteers were recruited;all were male aged 26–38years（average 31.83±4.96 years）.Characteristic parameters reflecting the status of cardiovascular functions were extracted,which included left ventricular contraction,vascular elasticity and peripheral *** degree of fatigue was determined depending on the difference between the calendar age and biological age,which was calculated through the analysis of blood pressure value and characteristic *** on the values of pulse height variation and pulse time variation on a 30-s pulse graph,autonomic nervous function was *** parameters examined were marked on an equilateral polygon to form an irregular polygon of the actual figure,then health status was evaluated based on the coverage area of the actual ***：The results demonstrated：（1）volunteers developed weakened pulse power,increased vascular tension and peripheral resistance,and slight decreased ventricular systolic function;（2）the degree of fatigue was basically mild or moderate;and（3）autonomic nervous function was excited but generally ***：These volunteers were in the state of *** to Chinese medicine theories,such symptoms are mainly caused by the weakening of healthy qi,Gan（Liver）failing in free coursing,and disharmony between Gan and Wei（Stomach）,which manifests as a weak and string-like pulse.

关键词： pulse graph cardiovascular function fatigue autonomic nervous function sub-health

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