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sub-chronic Toxicity of Defoamer Used in Seawater Desalination

Biomedical and Environmental Sciences 2019年第5期32卷 334-344页

作者： DUAN Lian ZHANG Chong Hua GU Wen ZHI Hong KONG Jian ZHANG Shao Ping LI Yi Min LU Kai Institute for Environmental Health and Related Product Safety Chinese Center for Disease Control and PreventionBeijing 100020China The Centers for Disease Control and Prevention Harbin Harbin 150000HeilongjiangChina Chinese Center for Disease Control and Prevention Beijing 102206China

Objective To explore the possible long‐term health effects of the defoamer used in seawater desalination by sub‐chronic toxicity testing. Methods Blood analysis, internal organ assessment, and histopathological examination were carried out in rats exposed to low, medium, and high(0.5, 1.0, and 2.0 g/kg BW, respectively) doses of defoamer for 90 days through oral administration. Results The high dose group showed decreased blood alanine aminotransferase and aspartate aminotransferase(P < 0.05). All doses resulted in a significant increase in albumin and decrease in globulin(P < 0.05). The direct bilirubin and indirect bilirubin were decreased in the medium and high dose groups(P < 0.05). All dose groups showed significant induction of alkaline phosphatase(P < 0.05). Pathological examination revealed a case of liver mononuclear cell infiltration in the medium dose group and three cases of liver congestion, steatosis of hepatic cells around the central vein, and punctate necrosis with multiple focal mononuclear cell infiltration in male rats administered the high dose. The No Observed Adverse Effect Level was 0.5 g/kg BW in rats, with albumin and total bilirubin as health effect indices. Conclusion Long‐term defoamer exposure may cause liver injury but has no significant impact on renal function in rats. The effect on blood cells in female rats was more prominent than that in male rats.

关键词： Seawater desalination Defoamer sub‐chronic toxicity

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