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Recent strategies of collagen-based biomaterials for cartilage repair: from structure cognition to function endowment

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Journal of Leather Science and Engineering 2022年第1期4卷 152-174页

作者： Xiaoyue Yu Haiping Zhang Yiliang Miao Shanbai Xiong Yang Hu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070HubeiPeople’s Republic of China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070HubeiPeople’s Republic of China Bioactive Peptide Technology Hubei Engineering Research Center No.195 Dongfang AveJingzhou 434000HubeiPeople’s Republic of China.

Collagen,characteristic in biomimetic composition and hierarchical structure,boasts a huge potential in repairing cartilage defect due to its extraordinary bioactivities and regulated physicochemical properties,such as low immunogenicity,biocompatibility and controllable degradation,which promotes the cell adhesion,migration and ***,collagen-based biomaterial has been explored as porous scaffolds or functional coatings in cell-free scaffold and tissue engineering strategy for cartilage *** those forming technologies,freeze-dry is frequently used with special modifications while 3D-printing and electrospinning serve as the structure-controller in a more precise ***,appropriate cross-linking treatment and incorporation with bioactive substance generally help the collagen-based biomaterials to meet the physicochemical requirement in the defect site and strengthen the repairing ***,comprehensive evaluations on the repair effects of biomaterials are sorted out in terms of in vitro,in vivo and clinical assessments,focusing on the morphology observation,characteristic production and critical gene ***,the challenge of biomaterial-based therapy for cartilage defect repairing was summarized,which is,the adaption to the highly complex structure and functional difference of cartilage.

关键词： Collagen Cartilage repair Hierarchical structure structure cognition Function endowment

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