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Integrate Omics Data and Molecular Dynamics Simulations toward Better Understanding of Human 14-3-3 Interactomes and Better Drugs for Cancer Therapy

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Journal of Genetics and genomics 2015年第10期42卷 531-547页

作者： Jo Anne J.Babula Jing-Yuan Liu Department of Pharmacology and Toxicology Indiana University School of Medicine Department of Computer and Information Science Indiana University Purdue University Indianapolis

The 14-3-3 protein family is among the most extensively studied, yet still largely mysterious protein families in mammals to date. As they are well recognized for their roles in apoptosis, cell cycle regulation, and proliferation in healthy cells, aberrant 14-3-3 expression has unsurprisingly emerged as instrumentalin the development of many cancers and in prognosis. Interestingly, while the seven known 14-3-3 isoforms in humans have many similar functions across cell types, evidence of isoform-specific functions and localization has been observed in both healthy and diseased cells The strikingly high similarity among 14-3-3 isoforms has made it difficult to delineate isoform-specific functions and for isoform-specific targeting. Here, we review our knowledge of 14-3-3 interactome（s） generated by high- throughput techniques, bioinformatics, structural genomics and chemical genornics and point out that integrating the information with molecular dynamics （MD） simulations may bring us new opportunity to the design of isoform-specific inhibitors, which can not only be used as powerful research tools for delineating distinct interactomes of individual 14-3-3 isoforms, but also can serve as potential new anti-cancer drugs that selectively target aberrant 14-3-3 isoform.

关键词： Interactome Chemical genomics structural genomics Molecular dynamics simulation

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Twenty years of rice genomics research: From sequencing and functional genomics to quantitative genomics

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Molecular Plant 2022年第4期15卷 593-619页

作者： Changsheng Wang Bin Han National Center for Gene Research State Key Laboratory of Plant Molecular GeneticsCenter for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China

Since the completion of the rice genome sequencing project in 2005,we have entered the era of rice genomics,which is still in its *** genomics studies can be classified into three stages:structural genomics,functional genomics,and quantitative *** genomics refers primarily to genome sequencing for the construction of a complete map of rice genome *** is fundamental for rice genetics and molecular biology *** genomics aims to decode the functions of rice *** genomics is large-scale sequence-and statistics-based research to define the quantitative traits and genetic features of rice *** genomics has been a transformative influence on rice biological research and contributes significantly to rice breeding,making rice a good model plant for studying crop sciences.

关键词： rice Oryza sativa structural genomics functional genomics quantitative genomics

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Prospects for the Chinese Human Genome Project (HGP) at the beginning of next century

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Progress in Natural Science:Materials International 2000年第3期 14-18页

作者：陈竺 Chinese National Human Genome Center at Shanghai Shanghai 201203 China Shanghai Inslitute of Hematology Rui Jin Hospital Shanghai Second Medical University

Chinese Human Genome Project (CHGP) as part of the international human genome research has achieved significant progress and created a solid foundation for further development. While participating in the human genome sequencing and gene discovery, the emphasis of CHGP in the next century will be laid on functional genomics. The strategy, resources and some policy issues will be addressed.

关键词： Chinese Human Genome Project structural genomics functional genomics prospects.

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