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striae gravidarum as a predictor of spontaneous preterm delivery: A case control study

Open Journal of Obstetrics and Gynecology 2012年第4期2卷 394-397页

作者： Sefa Kelekci Servet Gencdal Orcun Ozdemir Emre Destegul Kiymet Handan Kelekci Dermatology Clinic Ataturk Education and Research Hospital Ministry of Health Izmir Turkey Obstetrics and Gynecology Clinic Adana Numune Education and Research Hospital Ministry of Health Adana Turkey Obstetrics and Gynecology Clinic Aegean Education and Research Hospital Ministry of Health Izmir Turkey

Background/Aims: The association between striae gravidarum (SG) and preterm delivery may be postulated because of sharing similar poor organization of extracellular matrix in both skin and cervix. Our goal was to compare the frequency of striae gravidarum in women who gave preterm birth and women who gave term birth. Methods: A case-control study was conducted in women who gave preterm birth (n = 66) and age matched women who gave term birth (n = 68). Cases and controls were recruited from puerperal women consequently seen at delivery wards of perinatology unit. All women underwent dermatologic examination in terms of SG blindly to theirs gestational weeks of delivery. The frequency of SG was compared in all groups. Results: The frequency of SG was 63.6% in women with preterm birth and 54.4% in women with term birth (p = 0.278). SG is five times more common in late preterm group than in women with term group, but this difference was not statistically significant [(p = 0.227, OR: 5.02, CI 95% (0.5 - 44.0)]. The rate of preventive cream usage was not statistically different in women with SG and without SG (p = 0.245). Conclusions: It seems that there was no statistically significant association between the risk of preterm labor and the presence of striae gravidarum. Larger prospective observational studies are needed to state expressly the probable clinical association between the presence of SG and preterm delivery.

关键词： Preterm Delivery Predictive Screening striae Distensae striae Gravidarum Term Delivery

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Morphological substantiation of application of cellular technologies for correction of striae

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Health 2010年第12期2卷 1430-1436页

作者： Igor Maiborodin Andrey Shevela Andrey Babko Vitaly Morozov Vera Matveeva 不详

The possibility of the application of autologic pluripotent cells from peripheral blood (APCPB) for correction of striae after pregnancy was studied. Visually first signs of improvement of atrophic scars can be noticed in 6-8 weeks after injection of APCPB and gradually progress during 6 months. The atrophy of epithelium, hyperkeratosis, sclerosis of all dermis layers with smoothing of papillae, reduction of number of blood vessels and skin appendages were found before treatment by method of light mi-croscopy. In all observations after injection of APCPB in a connective tissue, which replaces of dermis, an increase of number of vessels at the expense of processes of neoangiogenesis, leukocytic infiltration reduction, thinning and ordering of arrangement of collagen and elastin fibers were detected. These results give a chance for more successful application of cosmetology procedures for correction of these defects of skin.

关键词： Skin striae after Pregnancy Atrophy of Epidermis Dermal Sclerosis Pluripotent Cells from Peripheral Blood Neoangiogenesis

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Carbocysteine: A New Way for Stretch Marks Treatment

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第4期5卷 275-282页

作者： Francesco Scarci Federico Mailland Scientific Department Polichem S.A. Lugano Switzerland

Background/Purpose: Although stretch marks (or striae) do not represent a medical problem, they are considered as the cause of psychological distress for women of any age that need to be treated. There are many cosmetic products or procedures claiming to improve the appearance of striae, but most of them are able to affect only striae appearance rather than physical characteristics or, even worse, they are provided with untoward effects. Our aim was to find a more efficacious and safe alternative to the existing tools. Methods: A randomized, blind observer study was conducted on 33 women to test the efficacy and safety of P-3059, a new product containing carboxymethylcysteine, Vitamin E and sweet almond oil. P-3059 was applied twice daily for 8 weeks and it was tested intra-subject in a split-body design versus an untreated area (negative control), comparing two symmetric areas with striae selected on the body/legs of each subject. The main study endpoint was the visual evaluation of striae, by means of the validated POSAS scale (consisting of two parts, OSAS and PSAS), at the end of treatment in comparison with baseline. Results: The comparison of the individual parameters of OSAS, showed significantly improved mean values for striae thickness, relief and pliability at the end of treatment (p striae towards that of normal skin (p striae, reducing their thickness and improving relief and pliability, as well as subjects satisfaction.

关键词： striae Distensae Stretch Marks Emollient Carbocysteine Sweet Almond Oil

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