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DNA Nanotechnology-based Biocomputing

Chemical Research in Chinese Universities 2020年第2期36卷 219-226页

作者： YIN Jue WANG Junke NIU Renjie REN Shaokang WANG Dexu CHAO Jie Key Laboratory for Organic Electronics and Information Displays(KLOEID) Institute of Advanced Materials(IAM)Jiangsu Key Laboratory for BiosensorsSchool of Materials Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023R R.China

With silicon-based microelectronic technology pushed to its limit,scientists hunt to exploit biomolecules to power the bio-computer as substitutes.As a typical biomolecule,DNA now has been employed as a tool to create computing systems because of its superior parallel computing ability and outstanding data storage capability.However,the key challenges in this area lie in the human intervention during the computation process and the lack of platforms for central processor.DNA nanotechnology has created hundreds of complex and hierarchical DNA nanostructures with highly controllable motions by exploiting the unparalleled self-recognition properties of DNA molecule.These DNA nanostructures can provide platforms for central processor and reduce the human intervention during the computation process,which can offer unprecedented opportunities for biocomputing.In this review,recent advances in DNA nanotechnology are briefly summarized and the newly emerging concept of biocomputing with DNA nanostructures is introduced.

关键词： DNA computing DNA nanotechnology DNA strand-displacement Programmable self-assembly DNA origami

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A Triode-like Enzyme-free Catalytic Circuit with Junction Fuel

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Chemical Research in Chinese Universities 2020年第2期36卷 261-267页

作者： LUO Tao WANG Xiaojing FAN Sisi LIU Yan CHENG Jin TANG Linlin SONG Jie Institute of Nano Biomedicine and Engineering Department of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240P R.China

Target detection circuits have been previously designed,which are propelled by conventional PCR,isothermal amplification and strand-displacement reaction.These detection circuits obtain the target signal via the replication of the target strand,the aggregation of the signal particles or the branch migration.Here we constructed a tri-ode-like enzyme-free catalyst strand-displacement circuit for target DNA detection.The target strand triggered die reaction and released the fluorescence signal strand circularly through branch migration.However,the main challenge of strand-displacement reaction is the signal leakage.Therefore,we designed a double strand structure"junction fuel",which was used to increase the binding energy across the displacement process.Ultimately,the leakage of the system obtained stable inhabitation due to the junction fuel strand.The limit of detection of the system was as low as 0.11 nmol/L and the gain of the system was as high as 28-fold(the concentration of target was 50 nmol/L).Furthermore,the process of the system was visualized vividly in the reaction curve through the kinetic simulation implemented,which suggests that the combination of the kinetic simulation and the experiment exhibits a promising prospect towards the use of strand-displacement circuit in analytical,diagnostic application and synthetic biology.

关键词： Catalysis strand-displacement Junction fuel Triode-like Kinetic simulation

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