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The effects of starter microbiota and the early life feeding of medium chain triglycerides on the gastric transcriptome profile of 2-or 3-week-old cesarean delivered piglets

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Journal of Animal Science and Biotechnology 2018年第1期9卷 196-207页

作者： Paolo Trevisi Davide Priori Vincenzo Motta Diana Luise Alfons J.M.Jansman Sietse-Jan Koopmans Paolo Bosi DISTAL University of Bologna Viale Fanin 46 40127 Bologna Italy Wageningen University and Research Wageningen The Netherlands

Background： The stomach is an underestimated key interface between the ingesta and the digestive system, affecting the digestion and playing an important role in several endocrine functions. The quality of starter microbiota and the early life feeding of medium chain triglycerides may affect porcine gastric maturation. Two trials（T1, T2） were carried out on 12 and 24 cesarean-delivered piglets（birth, d0）, divided over two microbiota treatments, but slaughtered and sampled at two or three weeks of age, respectively. All piglets were fed orally： sow serum（T1） or pasteurized sow colostrum（T2） on d0; simple starter microbiota（Lactobacillus amylovorus, Clostridium glycolicum and Parabacteroides spp.）（d1-d3）; complex microbiota inoculum（sow diluted feces, CA） or a placebo（simple association, SA）（d3-d4） and milk replacer ad libitum（d0-d4）. The The T1 piglets and half of the T2 piglets were then fed a moist diet（CTRL）; the remaining half of the T2 piglets were fed the CTRL diet fortified with medium chain triglycerides and 7% coconut oil（MCT）. Total m RNA from the oxyntic mucosa was analyzed using Affymetrix？Porcine Gene array strips. Exploratory functional analysis of the resulting values was carried out using Gene Set Enrichment ***： Complex microbiota upregulated 11 gene sets in piglets of each age group vs. SA. Of these sets, 6 were upregulated at both ages, including the set of gene markers of oxyntic mucosa. In comparison with the piglets receiving SA, the CA enriched the genes in the sets related to interferon response when the CTRL diet was given while the same sets were impoverished by CA with the MCT ***： Early colonization with a complex starter microbiota promoted the functional maturation of the oxyntic mucosa in an age-dependent manner. The dietary fatty acid source may have affected the recruitment and the maturation of the immune cells, particularly when the piglets were early associated with a simplified starter microbiota.

关键词： Development Microbiota Pig stomach transcriptome

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