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Incidence and mortality of stomach cancer in China,2014

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Chinese Journal of cancer Research 2018年第3期30卷 291-298页

作者： Lei Yang Rongshou Zheng Ning Wang Yannan Yuan Shuo Liu Huichao Li Siwei Zhang Hongmei Zeng Wanqing Chen Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Beijing Office for Cancer Prevention and ControlPeking University Cancer Hospital & Institute National cancer Center/cancer Hospital Chinese Academy of Medical Science and Peking Union Medical College

Objective： In this study,we aimed to estimate the updated incidence and mortality rate of stomach cancer based on the cancer registration data in 2014,collected by the National Central cancer Registry of China（NCCRC）.Methods： In 2017,339 registries＇ data were qualified based on the criteria of data quality control of the *** of stomach cancer were retrieved from the national *** estimated numbers of stomach cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area,sex,agegroup（0,1–4,5–9,10–14,…,85＋）.Chinese standard population in 2000 and Segi＇s world population were applied for age-standardized incidence and mortality ***： In 2014,410,400 new stomach cancer cases and 293,800 cancer-associated deaths were estimated to have occurred in *** crude incidence rate of stomach cancer was 30.00/100,000,age-standardized incidence rates by Chinese standard population（ASIRC） and by world standard population（ASIRW） were 19.62/100,000 and19.51/100,000,*** crude mortality rate of stomach cancer was 21.48/100,000,age-standardized mortality rates by Chinese（ASMRC） and by world standard population（ASMRW） were 13.44/100,000 and13.30/100,000,*** and mortality rates in rural areas were both higher than that in urban *** cancer has a strong relationship with gender and *** disease has occurred more frequently among men than women with a male to female ratio of 2.4 for *** age group of 40-44 years,incidence rates are substantially higher in men than in women,same pattern was seen for age-specific mortality ***： There is still a heavy burden of stomach cancer in *** incidence and mortality patterns of stomach cancer show substantial gender and regional *** effort is needed to provide more accessible health services,sufficient financial resources,and adequate cancer-care infrastructure for the Chinese population,esp

关键词： Incidence mortality population-based stomach cancer

Epidemiology of stomach cancer

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World Journal of Gastroenterology 2022年第12期28卷 1187-1203页

作者： Milena Ilic Irena Ilic Department of Epidemiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Despite a decline in incidence and mortality during the last decades,stomach cancer is one of the main health challenges *** to the GLOBOCAN 2020 estimates,stomach cancer caused approximately 800000 deaths(accounting for 7.7%of all cancer deaths),and ranks as the fourth leading cause of cancer deaths in both genders *** 1.1 million new cases of stomach cancer were diagnosed in 2020(accounting for 5.6%of all cancer cases).About 75%of all new cases and all deaths from stomach cancer are reported in *** cancer is one of the most lethal malignant tumors,with a five-year survival rate of around 20%.There are some well-established risk factors for stomach cancer:Helicobacter pylori infection,dietary factors,tobacco,obesity,and *** date,the most important way of preventing stomach cancer is reduced exposure to risk factors,as well as screening and early *** research on risk factors can help identify various opportunities for more effective *** programs for stomach cancer have been implemented in a few countries,either as a national or opportunistic screening of high-risk individuals ***,due to its high aggressiveness and heterogeneity,stomach cancer still remains a severe global health problem.

关键词： stomach cancer Epidemiology Incidence Mortality Survival Predictive factors Prevention

Elevated DLL3 in stomach cancer by tumor-associated macrophages enhances cancer-cell proliferation and cytokine secretion of macrophages

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Gastroenterology Report 2022年第1期10卷 322-334页

作者： Jian-Bin Ye Jun-Jie Wen Dan-Lin Wu Bing-Xin Hu Mei-Qun Luo Yan-Qing Lin Yun-Shan Ning Yan Li School of Laboratory Medicine and Biotechnology Southern Medical UniversityGuangzhouGuangdongP.R.China Service Union Medicine Southern Medical UniversityZhuhaiGuangdongP.R.China

Background The notch signal pathway is important in the development of both tumor-associated macrophages(TAMs)and stomach cancer,but how Notch signaling affects TAMs in stomach cancer is barely *** The expressions of Notch1,Notch2,Notch3,Notch4,hes family bHLH transcription factor 1(Hes1),and delta-like canonical Notch ligand 3(DLL3)were detected by Western blot and the expressions of interleukin(IL)-10,IL-12,and IL1-b were detected using enzyme-linked immunosorbent assay after the co-culture of macrophages and stomach-cancer *** proliferation and migration of cancer cells were detected using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and scratch assay,respectively,and the cell cycle was detected using Annexin V/propidium iodide *** protein interactions with DLL3 were detected using co-immunoprecipitation and mass *** The co-culture of macrophages and stomach-cancer cells MKN45 and BGC823 could enhance cell proliferation accompanied by the activation of Notch1/Notch2 signaling and upregulation of *** signaling gamma-secretase inhibitor(DAPT)blocked this *** overexpression of DLL3 in stomach-cancer cells could promote the proliferation of cancer cells,enhance the activation of Notch1/Notch2 signaling,induce the expression of IL-33,lead to the degradation of galectin-3–binding protein(LG3BP)and heat shock cognate 71 kDa protein(HSPA8),and result in elevated IL-1b,IL-12,and IL-10 secretion by *** expression of DLL3 or IL-33 could lead to a lower survival rate based on University of California,Santa Cruz Xena Functional Genomics Explorer and The cancer Genome Atlas data *** This is evidence that DLL3 regulates macrophages in stomach cancer,suggesting that DLL3 may be a novel and potential target for stomach-cancer therapy.

关键词： stomach cancer DLL3 macrophages Notch signaling,proliferation cytokines

High scored thyroid storm after stomach cancer perforation: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8768-8774页

作者： Seung Min Baik Yejune Pae Jae-Myeong Lee Department of Surgery Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985South Korea Department of Surgery College of MedicineGraduate School of Korea UniversitySeoul 02841South Korea Department of Acute Care Surgery Korea University Anam HospitalSeoul 02841South Korea

BACKGROUND Thyroid storm is a life-threatening ***,the prevalence of thyroid storm is 1%-2%among patients admitted to the hospital for *** and Wartofsky(1993)introduced a scoring system using precise clinical criteria to identify thyroid *** 17 cases of thyroid storm with a score>70 points have been *** thyroid storms are uncommon,their clinical findings resemble those of *** SUMMARY A 48-year-old man was referred to the emergency room from a local clinic owing to suspicion of gastric ulcer perforation;medications for hypertension,diabetes mellitus,and hyperthyroidism had been suspended 1 year prior to this *** performed an emergency distal gastrectomy with Billroth II anastomosis for gastric cardia cancer perforation,and the patient was referred to the surgical intensive care unit(ICU).On the 2nd d in the ICU,his body temperature(BT)increased to 41.3℃ at 19:00,with the thyroid storm score(90 points)peaking at 18:00(BT;41.2℃,pulse rate;138/min,irritable status).The patient was administered propylthiouracil,intravenous glucocorticoids,acetaminophen,and Lugol’s solution ***,we performed bladder irrigation with cold saline using a Foley catheter and applied a hypothermic blanket to decrease the patient's *** vital signs were stable on the 8th day in the *** Thyroid storms are uncommon,with few reports in the literature;however,their clinical findings resemble those of sepsis and require further *** an untreated thyroid storm results in a high mortality rate,it should be investigated when managing sepsis.

关键词： Thyroid storm stomach cancer Severity score Sepsis Case report

A　NEW　FUNCTIONAL　CLASSIFICATION　OF　stomach　cancer　AND　ITS　PATHOBIOLOGICAL　AND　CLINICAL　SIGNIFICANCE

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Chinese Medical Sciences Journal 1994年第2期9卷 119-124页

作者：辛彦赵风凯宫伟王艳萍张荫昌闫瑞方 cancerInstitute ChinaMedicalUniversityShenyang110001 CenterLaboratory CancerHospitalofLiaoningProvinceShenyang110042

The functional differentiations of stomach cancer specimens from 121 patients were investigated by enzyme-,mucin-,affinity-and immunohistochemical methods, and the stomach cancers were divided into five functionally differentiated types : 1 ) Absorptive Function Differentiation Type (AFDT), 19. 8% ; 2) Mucin Secreting Function Differentiation Type(MSFDT) , 24. 0% ; 3) Absorptive and Mucin-Producing Function Differentiation Type(AMPFDT) , 47. 1%; 4 ) Special Function Differentiation Type(SFDT) , 0. 8 %; and 5) Non-Function Differentiation Type(NFDT) , 8. 3%. The results indicate that stomach cancer tissues of the same histological type often display differing functional differentiation, and these functionally differentiated types have different invasive and metastatic characteristics. In addition, the functionally differentiated types have particular organic affinities of metastasis and different clinical prognoses. This study suggests that this new functional classification may supplement histological classification. The mechanisms of liver and ovary metastases of stomach cancer are also dis-cussed.

关键词： stomach cancer functional classification histochemistry

BIOLOGICAL　EFFECTS　OF　TWEEN－80　IN　COMBINATION　WITH　HYPERTHERMIA　ON　HUMAN　stomach　cancer　CELL　LINE　BGC－823

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Chinese Journal of cancer Research 1994年第4期6卷 252-258页

作者：杨虎川杨耀琴陶惠红周君怡王永德 1. Shanghai Railway Medical Collage 200070 Shanghai

Various biological indices were used to observe the effects of Tween-80 in combination with hyperthermia at different temperature (39-43℃) for different period of time (20-100 minutes) on human stomach cell line BGC-823. The results showed that Tween-80obviously reduced the activation energy of BGC-823 cells. Synergistic effect was observed if applied with heat at 39℃ with the increase in temperature and time,the inhibitory effect on the cancer cells was gradually intensified. The lethal rate of BGC-823 cells treated by heat at 41℃ in combination with Tween-80 was around 5.2 times as that treated by hyperthermia alone. The synergistic effect of heat at 41℃ for 100 min. in combination with Tween-80 was equivalent to the effect of 43℃ for 100 *** other words, the critical temperature for BGC-823 cells was hereby reduced about 2℃. The measurement of membrane mobility, SDH activity *** showed that at 41℃ the synergistic effect of hyperthermia in combination with Tween-80 was the best, it exceeding the single effect of these factors in combination and showing effect of multiplication. The synergistic effect of heat at 41℃ in combination with Tween-80 was higher than that of heat at 41℃ in combination with MMC. It also demonstrated that the specific and sustained action on the inhibition of cancer cells did exist. These studies suggested that the synergistic mechanism of Tween-80 and hyperthermia probably was that both of them acted on the cell membrane system. Supported by The National Natural Science Fund of China (No. 3860948)

关键词： stomach cancer cancer cell line BGC-823,Tween-80 Hyperthermia Biological effect.

AN EPIDEMIOLOGICAL EVIDENCE OF MULTISTAGE PROCESS OF stomach cancer

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Chinese Journal of cancer Research 1994年第2期6卷 113-118页

作者：游伟程李吉友罗云生全懋林韩中祥徐光炜 1. Beijing Institute for cancer Research 100034 Beijing China 2. National cancer Institute 20892 Bethesda MD USA 3. Weifang Medical Institute 261041 Shandong China 4. Linqu Public Health Bureau 252600 Linqu Shandong China

An endoscopic screening examination was conducted in Linqu county, Shandong Province of China, an area with one of the highest rates for stomach cancer (SC) in the world. A total of 3, 433 residents aged 35 64 were enrolled in this *** than 3% of the subjects had normal or superficisl gastritis(SG), 44. 8% had chronic atrophic gastritis(CAG),33.0% had intestinal metaplasia (IM)and 20. 1% had dysplasia (DYS) as the meet advanced gastric lesions in this population. The transition rates from normal to advanced lesions and SC were calculated in overall and different anatomic locations of the stomach. The transition rates were 98. 3% from SG to CAG, 55.1% from CAG to IM, 38. 3% from IM to DYS and 2. 0% from DYS to SC. Tbe transition rates were significantly higher in the angulus and lesser curvature of antrum than other sites, particularly in the sites of the *** from this study showed that SC may undergo 3050 years' latent period and involves a multistage *** probability of transition from normal mucosa to SC is dependept on the transition rate of each intermdiate stage of precancerous lesions.

关键词： stomach cancer Epidemiology Precancerous lesion multistage.

FACTORS INFLUENCING SERUM PEPSINOGEN LEVELS IN A CHINESE POPULATION AT HIGH RISK OF stomach cancer

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Chinese Journal of cancer Research 1993年第3期5卷 4-11页

作者：昌云生游伟程张联赵雷马骏岭刘宪秋刘伟东 RobertW.Kneller 张劲松 MichealI.Samloff WilliamJ.Blot Weifang Medical Institute Weifang 261041 Shandong China Beijing Institute far cancer Research Beijing 100034 Linqu Public Health Bureau Lmqu 252600 Shandong China Verterans Administration Medical Center Sepulveda CA USA 91343 National cancer Institute Betheada Maryland USA 20892he relationships between serum pepsinogen (PG) levels and age sex ABO blood type cigarette smoking and diet were studied among over 3 000 residents selected at random in an area with high risk of stomach cancer in Shandong Province China. Males had significantly higher median PG Ⅰ and Ⅱ levels than feamles. PG Ⅰ tended to decrease and PG Ⅱ to rise with age. Subjects with blood type A had a higher PG Ⅱ level than subjects with other blood types. Both PG Ⅰ and Ⅱ levels rose with dally consumption of cigarettes. Alcohol consumption was not related to PG levels. The PG Ⅰ/Ⅱ ratio declined with increasing consumption of sour pancakes a fermented staple food found to contain N-nitroso compounds and to be a risk factor for stomach cancer in this population.

The relationships between serum pepsinogen (PG) levels and age, sex, ABO blood type, cigarette smoking and diet were studied among over 3, 000 residents selected at random in an area with high risk of stomach cancer in Shandong Province, China. Males had significantly higher median PG Ⅰ and Ⅱ levels than feamles. PG Ⅰ tended to decrease and PG Ⅱ to rise with age. Subjects with blood type A had a higher PG Ⅱ level than subjects with other blood types. Both PG Ⅰ and Ⅱ levels rose with dally consumption of cigarettes. Alcohol consumption was not related to PG levels. The PG Ⅰ/Ⅱ ratio declined with increasing consumption of sour pancakes, a fermented staple food found to contain N-nitroso compounds and to be a risk factor for stomach cancer in this population.

关键词： Serum pepainogen stomach cancer Risk factors.

Review of salt consumption and stomach cancer risk:Epidemiological and biological evidence

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World Journal of Gastroenterology 2009年第18期15卷 2204-2213页

作者： Xiao-Qin Wang Paul D Terry Hong Yan Department of Epidemiology School of Medicine Xi'an Jiaotong University Xi'an 710061Shaanxi Province China Department of Epidemiology Rollins School of Public Health Emory University 1518 Clifton Road NE Atlanta GA 30322 United States

stomach cancer is still the fourth most common cancer;thus,it remains an important public health burden worldwide,especially in developing *** remarkable geographic variations in the rates of stomach cancer indicate that dietary factors,including a range of food groups to which salt and/or nitrates have been added,may affect stomach cancer *** this paper,we review the results from ecologic,case-control and cohort studies on the relationship between salt or salted foods and stomach cancer *** majority of ecological studies indicated that the average salt intake in each population was closely correlated with gastric cancer *** case-control studies showed similar results,indicating a moderate to high increase in risk for the highest level of salt or salted food *** overall results from cohort studies are not totally consistent,but are suggestive of a moderate direct *** salt intake has been correlated with Helicobacter pylori(H pylori) infection,it is possible that these two factors may synergize to promote the development of stomach ***,salt may also cause stomach cancer through directly damaging gastric mucus,improving temporary epithelial proliferation and the incidence of endogenous mutations,and inducing hypergastrinemia that leads to eventual parietal cell loss and progression to gastric *** on the considerable evidence from ecological,case-control and cohort studies worldwide and the mechanistic plausibility,limitation on salt and salted food consumption is a practical strategy for preventing gastric cancer.

关键词： Disease prevention Helicobacter pylori infection Salt consumption stomach cancer