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sterols from the Fungus Catathelasma imperiale

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Chinese Journal of Chemistry 2003年第10期21卷 1390-1394页

作者：杨升平徐军岳建民 State Key Laboratory of Drug Research

Eight ergostane type sterols and three their derivatives (one mono linoleate and two mono glucosides) were isolated from the ethyl acetate soluble fraction of the fungus Catathelasma imperiale . Two of them are novel compounds, namely 22 E ,24 R ergosta 7,22 diene 3 β ,5 α diol 6 β linoleate (1) and 22 E ,24 R ergosta 7,22 diene 3 β ,5 β ,6 α triol (5) with an uncommon cis fused A/B ring. Structures of these compounds were demonstrated on the basis of their chemical evidences and spectroscopic methods, especially 2D NMR techniques.

关键词： fungus,Catathelasma imperiale sterol

Mori Cortex extract ameliorates nonalcoholic fatty liver disease( NAFLD) and insulin resistance in high-fat-diet/streptozotocininduced type 2 diabetes in rats

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Chinese Journal of Natural Medicines 2018年第6期16卷 411-417页

作者： MA Li-Li YUAN Yan-Yan ZHAO Ming ZHOU Xin-Rong Tashina Jehangir WANG Fu-Yan XI Yang BU Shi-Zhong Runliang Diabetes Laboratory Diabetes Research Center School of Medicine Ningbo University

Nonalcoholic fatty liver disease(NAFLD) and type 2 Diabetes Mellitus(T2 DM) are highly prevalent diseases and are closely associated, with NAFLD being present in the majority of T2 DM patients. In Asian traditional medicine, Mori Cortex is widely used for the treatment of diabetes and hyperlipidemia. However, whether it has a therapeutic effect on T2 DM associated with NAFLD is still unknown. The present study showed that the oral treatment with Mori Cortex extract(MCE; 10 g·kg-1·d-1) lowered the blood lipid levels and reversed insulin resistance(IR) in high fat-diet/streptozotocin-induced type 2 diabetes in rats. The expression levels of sterol receptor element-binding protein-1 c(SREBP-1 c) and carbohydrate-responsive element binding protein(Ch REBP), which are involved in steatosis in NAFLD rats, were measured in the liver samples. MCE decreased the protein and m RNA expression levels of SREBP-1 c and Ch REBP. In conclusion, down-regulation of SREBP-1 c and Ch REBP might contribute to the protective effect of MCE on hepatic injury and IR in the rats with T2 DM associated with NAFLD.

关键词： Mori Cortex extract Type 2 diabetes Non-alcoholic fatty liver sterol receptor element-binding protein-It Carbohy-drate-responsive element binding protein

Tracing the settlement region of massive floating green algae in the Yellow Sea

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Journal of Oceanology and Limnology 2019年第5期37卷 1555-1565页

作者： GENG Huixia YU Rencheng ZHANG Qingchun YAN Tian KONG Fanzhou ZHOU Mingjiang Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology (Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Outbreaks of large-scale green tides formed by Ulva prolifera in the Yellow Sea (YS) cause heavy ecological damages and huge economic losses. However, the ecological consequences of green tides remain poorly understood due to the lack of knowledge on the settlement region of massive green algae floating in the YS. In this study, we established a method to trace the settlement region of floating green algae, using 28-isofucosterol preserved in sediment as the specific biomarker for green algae. sterols including 28-isofucosterol in surface sediment samples collected during an investigation in the YS and the Bohai Sea (BS) in August 2015 were analyzed using gas chromatography coupled with a mass spectrometer (GC-MS). Based on the content of 28-isofucosterol in sediment samples, the potential settlement region of fl oating green algae was identifi ed in the sea area southeast to the Shandong Peninsula around the sampling site H06 (122.66°E, 36.00°N). This paper presents a first result on the settlement region of floating green algae in the YS for providing a solid basis to elucidate the ecological consequences of green tides in the area.

关键词： green tide biomarker sterol Ulva prolifera

Two New sterols from Bolbostemma paniculatum

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Chinese Chemical Letters 2003年第10期14卷 1037-1040页

作者： Wen Yong LIU, Wei Dong ZHANG, Hai Sheng CHEN, Zheng Ring GU, Ting Zhao LI, Wan Sheng CHENCollege of Pharmacy, Second Military Medical University, Shanghai 200433 College of Pharmacy Second Military Medical University Shanghai 200433 China

Two new sterols were isolated from bulbs of Bolbostemma paniculatum (Maxim.) Franquet. Their structures were elucidated as stigmasta-7, 22, 25-triene-3-O-nonadecanoic acid ester (1) and stigmasta-7, 22, 25-triene-3-O-... 详细信息

关键词： Bolbostemma paniculatum sterol stigmasta-7 22 25-triene-3-O-nonadecanoic acid ester stigmasta-7 22 25-triene-3-O-B-D- (6'-palmitoyl) glucopyranoside.

The Identification of Two New sterols from Marine Organism

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Chinese Chemical Letters 2000年第6期11卷 531-534页

作者： Shi Hai XU Long Mei ZENG(Department of Chemistry, Jinan University Guanzhou 510632)(Department of Chemistry Zhongshan University Guanzhou 510275) Department of Chemistry Jinan University Guanzhou 510632 China Department of Chemistry Zhongshan University Guanzhou 510275 China

Two new sterol have been isolated from the South China Sea marine organism. Compound 1 was isolated from the sponge Polymastia sobustia and compound 2 was obtained from the soft coral Sinularia inexplicata. Their structures were established as 3 beta-hydroxy-stigmast-5en-7-one and 24-methylene cholestan -3 beta, 6 beta, 9 alpha, 19-tetrol by variety of spectral analysis such as IR, EIMS, 1DNMR, H-1-H-1 COSY, HMQC, HMBC, NOESY.

关键词： sterol Polymastia sobustia 3 beta-hydroxy- stigmast-5en-7-one soft coral Sinularia inexplicita 24-methylene cholestan-3 beta, 6 beta, 9 alpha, 19-tetrol

Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell

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Acta Oceanologica Sinica 2008年第1期27卷 147-151页

作者： SHI Dayong XU Feng HE Juan SHI Jiangong FAN Xiao HAN Lijun Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Institute of Materia Medica Chinese Academy of Medical Sciences and Beijing Union Medical College Beijing 100050 China Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China

Chemical investigation of the ethanol extract of the marine green alga Chaetomorpha basiretorsa Setchell led to the isolation of a new sterol stigmast-4,28-dien-3α,6β-diol 1 in addition to the five known sterols of β-lawsaritol 2, saringosterol 3, 24-hydroperoxy-24-vinyl - cholesterol 4, β-stigmasterol 5, 29-hydroxystigmasta-5, 24 （28） -dien-3β-ol 6. Compounds were isolated by normal phase silica gel and Sephadex LH - 20 gel colum chromatography, reverse phase HPLC and recrystalization. Their structures were elucidated by spectroscopic methods including MS, IR 1D/2D NMR and X-ray analysis. Cytotoxicity of compounds was screened by using the standard MTF method. All these compounds were isolated from the green alga Chaetomorpha basiretorsa Setchell for the first time and they were inactive （50% inhibitory concentration was greater than 10 μg/cm^3） against KB, Bel -7402, PC - 3M, Ketr 3 and MCF-7 cell lines.

关键词： green alga sterol X-ray crystal structure

Chemical Constituents from Bletilla ochracea Schltr.

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Chemical Research in Chinese Universities 2007年第6期23卷 705-707页

作者： CAI Jin-yan ZHAO Lin ZHANG De-zhi Faculty of Pharmaceutical Science Guangdong Pharmaceutical University Guangzhou 510006 P. R. China School of Life Science and Biopharmacy Guangdong Pharmaceutical University Guangzhou 510006 P. R. China

To study the chemical constituents in Bletilla ochracea Schltr. , repeated column chromatographies and preparative TLC were used for the isolation of compounds, and spectroscopic techniques （NMR, IR, UV and MS） were used for their structural identification. Seven compounds, 2,7-bis （ allyloxy ） -5-methoxy-3-methyl-9, 10-dihydrophenanthrene（1）, gastrodin（2）, gastrodigenin（3）, β-sitosterol（4）, stigmasterol（5）, 4-hydroxybernzaldehyde（6）, and daucosterol（7） were obtained from the roots of B. ochracea Schltr. Compound 1 is structurally illustrated as a novel compound, and the others are isolated from the title plant for the first time.

关键词： Bletilla ochracea Schltr. Dihydrophenanthrene Gastrodin sterol

Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses

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World Journal of Cardiology 2015年第5期7卷 277-286页

作者： Annette Graham Anne-Marie Allen Department of Life Sciences School of Health and Life Sciences and the Institute for Applied Health Research (Diabetes Research Group)Glasgow Caledonian University

The aim of this review is to explore the role of mitochondria in regulating macrophage sterol homeostasis and inflammatory responses within the aetiology of atherosclerosis.Macrophage generation of oxysterol activators of liver X receptors(LXRs),via sterol 27-hydroxylase,is regulated by the rate of flux of cholesterolto the inner mitochondrial membrane,via a complex of cholesterol trafficking proteins.Oxysterols are key signalling molecules,regulating the transcriptional activity of LXRs which coordinate macrophage sterol metabolism and cytokine production,key features influencing the impact of these cells within atherosclerotic lesions.The precise identity of the complex of proteins mediating mitochondrial cholesterol trafficking in macrophages remains a matter of debate,but may include steroidogenic acute regulatory protein and translocator protein.There is clear evidence that targeting either of these proteins enhances removal of cholesterol via LXRα-dependent induction of ATP binding cassette transporters(ABCA1,ABCG1) and limits the production of inflammatory cytokines; interventions which influence mitochondrial structure and bioenergetics also impact on removal of cholesterol from macrophages.Thus,molecules which can sustain or improve mitochondrial structure,the function of the electron transport chain,or increase the activity of components of the protein complex involved in cholesterol transfer,may therefore have utility in limiting or regressing atheroma development,reducing the incidence of coronary heart disease and myocardial infarction.

关键词： Atherosclerosis Macrophage Cholesterol High density lipoproteins Apolipoproteins ATP binding cassette transporters Scavenger receptor B1 Mitochondria(dys)function sterol 27-hydroxylase Liver X receptors

Effects of free sterols on the fluidity of polar lipids in rice dry embryo

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Chinese Science Bulletin 1999年第10期44卷 933-937页

作者： YANG Ling and SU Weiai Biology Department of Zhejiang Normal University, Jinhua 321004, China Shanghai Institute of Plant Physiology , Chinese Academy of Sciences , Shanghai 200032 , China Biology Department of Zhejiang Normal University Jinhua China Shanghai Institute of Plant Physiology Chinese Academy of Sciences Shanghai China

Free sterols from rice dry embryo reduce the onset phase transition temperature and widen the transition range of total polar lipids and phosphatidylglycerol, which increases the membrane fluidity below their phase transition temperature and decreases the fluidity of membranes above their phase transition temperature. And 50% of free sterols result in a complete disappearance of phase transition. The fluidity of other main components of polar lipids is decreased by free sterols above 0℃. The results confirm that free sterols can modulate membrane lipid fluidity.

关键词： free sterol membrane lipids fluidity rice embryo.