检索结果-南通市图书馆

Immediate intraocular pressure rise after intravitreal injection of ranibizumab and two doses of triamcinolone acetonide

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2011年第4期4卷 402-405页

作者： Gul Arikan Ali Osman Saatci Ferit Hakan Oner Department of Ophthalmology School of Medicine Dokuz Eylul University

AIM: To evaluate prospectively immediate intraocular pressure (IOP) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide. METHODS: Patients who underwent intravitreal injection of 0.1mL (4mg) triamcinolone acetonide (TA, Group T4), 0.05mL (2mg) TA (Group T2) and 0.05mL (0.5mg) ranibizumab (Group R) comprised the study population. Overall, 229 eyes of 205 patients were injected. Fifty-four eyes (23.6%) were in Group T4, 69 eyes (30.1%) in Group T2 and 106 eyes (46.3%) in Group R. If IOP was less than 26mmHg immediately after the injection no further measurement was performed. If IOP was ≥26mmHg, IOP was remeasured till the reading was below 26mmHg at 5, 15 and 30 minutes. RESULTS: Immediately after the injection, the IOP of 28 eyes (51.9%) in Group T4, 22 eyes (31.9%) in Group T2 and 51 eyes (48.1%) in Group R were over 25mmHg. At 30 minutes, IOP of one eye (1.9%) in group T4, two eyes (2.9%) in group T2 and two eyes (1.9 %) in Group R were over 25mmHg. Immediate post-injection IOP was significantly higher in Group T4 and Group R when compared to Group T2 (P <0.001 and P <0.001, respectively). IOP was significantly higher in eyes without vitreous reflux when compared to those with vitreous reflux in all groups (P <0.001). CONCLUSION: IOP may remarkably increase immediately after the intravitreal injection of 2 or 4mg triamcinolone acetonide, and 0.5mg ranibizumab. Absence of vitreous reflux is the most important predicting factor for immediate IOP rise after the injection.

关键词： anti-VEGF agents glaucoma intraocular pressure intravitreal injection steroids

Brown Algae (Phaeophyceae) from the Coast of Madagascar:preliminary Bioactivity Studies and Isolation of Natural Products

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2015年第5期5卷 223-235页

作者： Marie Pascaline Rahelivao Margit Gruner Hanta Andriamanantoanina Ingmar Bauer Hans-Joachim Knolker Department Chemie Technische Universitat DresdenBergstraße 6601069 DresdenGermany Centre National de Recherche sur l’Environnement MESupResBP 1739101 AntananarivoMadagascar

Eight species of brown algae(Phaeophyceae)from the coast of Madagascar have been investigated for their chemical constituents.Fucosterol(3)was obtained as the most abundant compound.The brown alga Sargassum ilicifolium was the source for the first isolation of the terpenoid C27-alcohol 1,10,2-trinorsqualenol(1)from marine sources.From S.incisifolium we isolated the highly unsaturated glycolipid 1-O-palmitoyl-2-O-stearidonoyl-3-O-β-D-galactopyranosylglycerol(4)and we report the first full assignment of its ^(1)H and ^(13)C NMR data.Apo-90-fucoxanthinone(8)along with 24-ketocholesterol(5),(22E)-3b-hydroxycholesta-5,22-dien-24-one(6),and saringosterol(7)were obtained from Turbinaria ornata.The crude extracts of all eight species of brown algae exhibited a pronounced antimicrobial activity against the Gram-positive bacteria Bacillus cereus,Staphylococcus aureus,and Streptococcus pneumoniae.

关键词： Brown algae steroids Terpenoids NMR spectroscopy Antimicrobial activity

Advances in diagnosis and non-surgical treatment of Bell's palsy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2015年第1期10卷 7-12页

作者： Yang Zhao Guodong Feng Zhiqiang Gao Department of Otolaryngology Peking Union Medical College Hospital China Medical Science Academy

Bell’s palsy is a commonly seen cranial nerve disease and can result in compromised facial appearance and functions. Its etiology, prognosis and treatment are still being debated. This paper is a review of recent dev... 详细信息

关键词： Facial paralysis Non-surgical treatment steroids

Impacts of plant secondary metabolites from conifer litter on the decomposition of Populus purdomii litter

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2019年第6期30卷 2237-2245页

作者： Xiaoxi Zhang Boya Wang Zengwen Liu College of Life Sciences Yan’an UniversityYan’an 716000People’s Republic of China Institute of Soil and Water Conservation Northwest A&F UniversityYangling 712100People’s Republic of China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100People’s Republic of China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of AgricultureNorthwest A&F UniversityYangling 712100People’s Republic of China

A decomposition experiment of Populus purdomii litter,a commonly used afforestation species in the Qinling Mountains,China,was conducted.Water extracts of five conifer litters were used to treat P.purdomii litter and its soil.The P.purdomii litter was incubated at room temperature(20–25℃)and constant soil moisture for 6 months.During the decomposition period,the dynamics of litter mass and nutrient contents were detected to investigate the impacts of plant secondary metabolites.The results indicate that litter extracts of Pinus tabuliformis,Platycladus orientalis,Pinus armandii and Larix principisrupprechtii significantly inhibited the overall nutrient release of P.purdomii litter,while the last three types of litter extracts simultaneously inhibited its decomposition.Conversely,the litter extracts of Picea asperata significantly accelerated the overall nutrient release of P.purdomii.Generally,most of the conifer species,whose litter released terpenoids,phenolics,steroids,and aliphatic acids,will inhibit the decomposition and/or nutrient release from P.purdomii litter.Their negative effects on the decomposers and soil enzymatic activities indicates that planting diversity should be lower when mixed planted with P.purdomii.

关键词： Mixed afforestation Inhibited litter decomposition Terpenoids Phenolics steroids Aliphatic acids

Dementia and osteoporosis in a geriatric population: Is there a common link?

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2017年第5期8卷 412-423页

作者： Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis University of Leeds School of Medicine Department of Anaesthetics Pinderfields Hospital Department of Trauma and Orthopaedics the Royal Liverpool University Hospital Academic Department of Orthopaedics and Trauma Aristotle University Medical School

AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords "osteoporosis", "osteoporotic fracture", "dementia" and "Alzheimer's disease"(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet inde

关键词： Osteoporosis Fracture Dementia Thyroid disease Alzheimer’s disease Elderly Vitamin D Vitamin K Calcium Statins Alcohol Sex steroids

Sex differences in traumatic brain injury:a multi-dimensional exploration in genes,hormones,cells,individuals,and society

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Neurosurgical Journal 2019年第4期5卷 220-228页

作者： Cheng Ma Xin Wu Xiaotian Shen Yanbo Yang Zhouqing Chen Xiaoou Sun Zhong Wang Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversityJiangsu Province188 Shizi StreetSuzhou 215006China Shanghai Medical College Fudan UniversityShanghai 200032China

Traumatic brain injury(TBI)is exceptionally prevalent in society and often imposes a massive burden on patients'families and poor prognosis.The evidence reviewed here suggests that gender can influence clinical outcomes of TBI in many aspects,ranges from patients'mortality and short-term outcome to their long-term outcome,as well as the incidence of cognitive impairment.We mainly focused on the causes and mechanisms underlying the differences between male and female after TBI,from both biological and sociological views.As it turns out that multiple factors contribute to the gender differences after TBI,not merely the perspective of gender and sex hormones.Centered on this,we discussed how female steroid hormones exert neuroprotective effects through the anti-inflammatory and antioxidant mechanism,along with the cognitive impairment and the social integration problems it caused.As to the treatment,both instant and long-term treatment of TBI requires adjustments according to gender.A further study with more focus on this topic is therefore suggested to provide better treatment options for these patients.

关键词： Traumatic brain injury Gender Sex differences Female steroids Microglia Cognitive impairment Dopamine Social impairment

An examination by GC×GC-TOFMS of organic molecules present inhighly degraded oils emerging from Caribbean terrestrial seeps of Cretaceous age

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第1期10卷 5-15页

作者： Alan G.Scarlett Ana Ibis Despaigne-Diaz Simon A.Wilde Kliti Grice Western Australian Organic and Isotope Geochemistry Centre The Institute for Geoscience Research Curtin University Department of Applied Geology The Institute for Geoscience Research Curtin University

For our ancestors, oil seeps were both a fascination and a resource but as the planet's reserves of high quality low density oil becomes increasingly depleted, so there is now a renewed interest in heavier,biodegraded oils such as those encountered in terrestrial seeps. One such seep is Pitch Lake in the Caribbean island of Trinidad, which is the largest natural deposit of asphalt in the world. At the northern end of the Caribbean, oil emerges along a tectonic contact on the island on Cuba. The sources of the oils from these seeps are relatively recent and both are subject to intense weathering due to the tropical conditions. When analysed by gas chromatography(GC) both oils appear as unresolved complex mixtures(UCM) and show a very high degree of biodegradation thus presenting an analytical challenge. In this case study, these two Caribbean seep oils were analysed by comprehensive two dimensional GC with time of flight mass spectrometry(GC×GC-TOFMS) to expose many thousands of the individual compounds that comprise the UCM. The high chromatographic resolution of the GC×GC-TOFMS produced good quality mass spectra allowing many compounds including molecular fossil ‘biomarkers' to be identified. Compound classes included diamondoid hydrocarbons, demethylated hopanes and secohopanes, mono-and tri-aromatic steroids. D-ring aromatised structures of the 8,14-seco-hopanes,including demethylated forms were present in both oils but further demethylation, probably at position C-25 during biodegradation, was only observed in the Pitch Lake oil. Many polycyclic aromatic hydrocarbons(PAHs) were absent although the fungal-derived pentacyclic PAH perylene was present in both oils. The presence of the angiosperm biomarker lupane in the Pitch Lake oil constrained the age to the Late Cretaceous. The higher degree of biodegradation observed in the Cuban oil was likely due to relatively slow anaerobic processes whereas oil within Pitch Lake was probably subject to additional more rapid aerobic metabolism within the lake.

关键词： Oil seep Biomarker Biodegradation GCxGC Diamondoids Aromatic steroids

Adjuvant effects of saponins on animal immune responses

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第3期8卷 153-161页

作者： RAJPUT Zahid Iqbal ARIJO Abdullah G. Department of Veterinary Medicine College of Animal Sciences Zhejiang University Department of Parasitology Sindh Agriculture University

Vaccines require optimal adjuvants including immunopotentiator and delivery systems to offer long term protection from infectious diseases in animals and man. Initially it was believed that adjuvants are responsible for promoting strong and sustainable antibody responses. Now it has been shown that adjuvants influence the isotype and avidity of antibody and also affect the properties of cell-mediated immunity. Mostly oil emulsions, lipopolysaccharides, polymers, saponins, liposomes, cytokines, ISCOMs (immunostimulating complexes), Freund’s complete adjuvant, Freund’s incomplete adjuvant, alums, bacterial toxins etc., are common adjuvants under investigation. Saponin based adjuvants have the ability to stimulate the cell mediated immune system as well as to enhance antibody production and have the advantage that only a low dose is needed for adjuvant activity. In the present study the importance of adjuvants, their role and the effect of saponin in immune system is reviewed.

关键词： Adjuvants Saponins Immunity Immunostimulators steroids Triterpenoid

Two New Sterols from Adenophora Stenanthina Subsp.Xifengensi

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1997年第4期13卷 98-101页

作者： HOU Zhen-fu SHIYan-ping MEI Shuang-xi LI Yu Institute of Or ganic Chemistry State Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou730000

ＴｗｏＮｅｗＳｔｅｒｏｌｓｆｒｏｍＡｄｅｎｏｐｈｏｒａＳｔｅｎａｎｔｈｉｎａＳｕｂｓｐ．ＸｉｆｅｎｇｅｎｓｉｓＨＯＵＺｈｅｎ－ｆｕ，ＳＨＩＹａｎ－ｐｉｎｇ，ＭＥＩＳｈｕａｎｇ－ｘｉａｎｄＬＩＹｕ＊（Ｉｎｓｔｉｔｕｔｅ... 详细信息

ＴｗｏＮｅｗＳｔｅｒｏｌｓｆｒｏｍＡｄｅｎｏｐｈｏｒａＳｔｅｎａｎｔｈｉｎａＳｕｂｓｐ．ＸｉｆｅｎｇｅｎｓｉｓＨＯＵＺｈｅｎ－ｆｕ，ＳＨＩＹａｎ－ｐｉｎｇ，ＭＥＩＳｈｕａｎｇ－ｘｉａｎｄＬＩＹｕ＊（ＩｎｓｔｉｔｕｔｅｏｆＯｒｇａｎｉｃＣｈｅｍｉｓｔｒ...

关键词： Adenophora stenanthina subsp.Xifengensis Campanulaceae steroids Sterols