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Liposomes as sterile preparations and limitations of sterilisation techniques in liposomal manufacturing

Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 88-95页

作者： Ming-Ren Toh Gigi N.C.Chiu Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore

Liposomes have been widely researched as a delivery system and there have been many manufacturing techniques used in the production of liposomal preparations,the most common being extrusion method which will be introduced in this *** because of the unique properties of liposomes and their susceptibility to chemical and physical degradation,sterilisation remains an unresolved issue in the manufacturing of liposomebased *** is especially pertinent in the pharmaceutical industry where liposomes are commonly prepared for intravenous ***,filtration and aseptic manufacturing are recommended for the preparation of sterile liposomal *** aseptic manufacturing techniques such as dense gas techniques have been devised to eliminate the need for terminal *** paper will highlight the limitations of the conventional techniques that are specific to the liposome preparation under the respective sterilisation conditions specified by the 2011 British Pharmacopoeia to achieve 106 Sterility Assurance Level,as well as modifications incorporated in the newer sterilisation technologies to overcome these *** paper will introduce these techniques in brief,including their advantages and limitations.

关键词： Liposomes sterilisation Manufacturing

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Innuendoes of sterilisation Drilling in Surface Mining Operations—A Case Study

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International Journal of Geosciences 2024年第5期15卷 458-477页

作者： Richard Gyebuni Festus Kunkyin-Saadaari Isaac Ekow Anaman Department of Mining Engineering University of Mine and Technology Tarkwa Ghana Mining Engineering Department Ghana Manganese Company Tarkwa Ghana

Surface mining operations play a crucial role in meeting the world’s increasing demand for mineral resources for the advancement of technology and debauched expansion of economies. The search for and exploitation of these mineral resources are therefore important for the sustainability of the mineral extraction industry. To this end, efficient mine planning must incorporate sterilisation drilling and effective waste rock management principles in the search and exploitation of these minerals. In this article, sterilisation drilling is being reviewed vis-a-vis the establishment of waste and tailings dump locations, backfilling of open pit excavations and mine closure giving critical attention to the minerals and mining laws of Ghana. Subsequently, a detailed case study of a surface mining operation that successfully incorporated sterilisation drilling in determining waste dump location in its mine planning process has been presented in this study. The findings indicate that the proposed waste dump location could present a potential mining prospect in the future based on enhanced milling capacity/technology and improved mineral commodity price;underscoring the significance of sterilization drilling in the sustainability of the mining industry.

关键词： sterilisation Exploration Backfilling Waste Dump Cutoff Grade

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Effect of Autoclave sterilisation on the Dimensional Stability and Tear Strength of Three Silicone Impression Materials

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Open Journal of Stomatology 2014年第12期4卷 518-526页

作者： Brian J. Millar Sanjukta Deb Restorative Dentistry Department of Primary Dental Care King’s College London Dental Institute London UK Department of Biomaterials Biomimetics & Biophotonics King’s College London Dental Institute London UK

Objectives: There is a risk of spreading infectious material via non-sterile impressions. The aim of this study was to compare the effect of autoclave sterilisation on dimensional stability and tear strength of impression materials. Methods: Twenty-four specimens were produced using a standard ruled test block for each of three impression materials (Affinis, Aquasil and Speedex) to test dimensional stability. Thirty tear strips for each material were prepared for the tear test (ISO 34-1). Specimens were randomly allocated to 3 different groups (autoclaved, disinfected or untreated). A non-contact scanner was used to analyse dimensional change and a universal testing machine was used to determine tear strengths. Results: There were no significant differences in the test dimensions measured for any of the three impression materials following autoclave treatment compared to the disinfected or untreated control groups. The tear strengths were not adversely affected by autoclave sterilisation at 134°C. Conclusion: These addition and condensation-cured silicone impression materials can be steam autoclaved without adverse effects on dimensional accuracy or tear strength.

关键词： Impressions Autoclaving sterilisation

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