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Latent brain infection with Moraxella osloensis as a possible cause of cerebral gliomatosis type 2:A case report

World Journal of Clinical Oncology 2020年第12期11卷 1064-1069页

作者： Tadej Strojnik Rajko Kavalar Kristina Gornik-Kramberger Maja Rupnik Slavica Lorencic Robnik MaraPopovic Tomaz Velnar Department of Neurosurgery University Medical Centre MariborMaribor SI-2000Slovenia Faculty of Medicine University of MariborMaribor SI-2000Slovenia Department of Pathology University Medical Centre MariborMaribor SI-2000Slovenia National Laboratory for Health Environment and FoodMaribor SI-2000Slovenia Institute of Pathology Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Neurosurgery University Medical Centre LjubljanaLjubljana 1000Slovenia

BACKGROUND The gram-negative aerobic bacterium Moraxella osloensis is an opportunistic pathogen in brain tissues.CASE SUMMARY The gram-negative aerobic bacterium Moraxella osloensis was isolated from a patient’s brain tissue during a stereotactic biopsy.CONCLUSION This is the first report of a brain tissue infection with Moraxella osloensis possibly causing brain gliomatosis.

关键词： Moraxella osloensis brain infection Cerebral gliomatosis Stereotactic brain biopsy Case report

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Germinomas of the basal ganglia and thalamus: Four case reports

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World Journal of Clinical Cases 2020年第19期8卷 4558-4564页

作者： Zhen-Chao Huang Qing Dong En-Peng Song Zhi-Jie Chen Jin-Hua Zhang Bo Hou Zheng-Qi Lu Feng Qin Department of Neurosurgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Neurology The Third Affiliated Hospital of Sun YatSen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND The early diagnosis of basal ganglia and thalamus germinomas is often difficult due to the absence of elevated tumor markers,and atypical clinical symptoms and neuroimaging features.CASE SUMMARY Four male children aged 8 to 15 years were diagnosed with germinomas in the basal ganglia and thalamus by stereotactic biopsy from 2017 to 2019.All patients developed hemiplegia except patient 4 who also had cognitive decline,speech disturbance,nocturnal enuresis,polydipsia,polyuria,precocious puberty and abnormalities of thermoregulation.All four cases were alpha-fetoprotein and beta-human chorionic gonadotrophin(p-HCG)negative except patient 3 who had slightly elevated p-HCG in cerebrospinal fluid(CSF).No malignant cells were detected in the patients'CSF.brain magnetic resonance imaging findings were diverse in these patients with the exception of the unique and common characteristics of ipsilateral hemisphere atrophy,especially in the cerebral peduncle.All patients were diagnosed with germinomas of the basal ganglia and thalamus by Stereotactic brain biopsy.CONCLUSION Stereotactic brain biopsy is necessary to confirm the diagnosis of ectopic germinomas.Serial neuroimaging studies can not only differentiate disease but also determine the biopsy site.

关键词： Intracranial germinoma Stereotactic brain biopsy Basal ganglia Thalamus Tumor marker Case report

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