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banking of perinatal mesenchymal stem/stromal cells for stem cellbased personalized medicine over lifetime:Matters arising

引用

World Journal of stem cells 2023年第4期15卷 105-119页

作者： Cheng-Hai Li Jing Zhao Hong-Yan Zhang Bin Wang stem cell Program of Clinical Research Center People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Clinical Laboratory People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Pharmacy Fuwai Central China Cardiovascular HospitalZhengzhou 450000Henan ProvinceChina Department of Neurosurgery People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina

Mesenchymal stromal/stem cells(MSCs)are currently applied in regenerative medicine and tissue *** clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for *** derived from either human adult or perinatal tissues have their own unique advantages in their medical ***,clinical studies are conducted by using of cultured MSCs after thawing or short-term cryopreserved-then-thawed MSCs prior to administration for the treatment of a wide range of diseases and medical ***,cryogenically banking perinatal MSCs for potential personalized medicine for later use in lifetime has raised growing interest in China as well as in many other ***,this has led to questions regarding the availability,stability,consistency,multipotency,and therapeutic efficiency of the potential perinatal MSC-derived therapeutic products after longterm *** opinion review does not minimize any therapeutic benefit of perinatal MSCs in many diseases after short-term *** article mainly describes what is known about banking perinatal MSCs in China and,importantly,it is to recognize the limitation and uncertainty of the perinatal MSCs stored in cryobanks for stem cell medical treatments in whole *** article also provides several recommendations for banking of perinatal MSCs for potentially future personalized medicine,albeit it is impossible to anticipate whether the donor will benefit from banked MSCs during her/his lifetime.

关键词： Mesenchymal stromal/stem cells Adult mesenchymal stromal/stem cells Perinatal mesenchymal stromal/stem cells Perinatal tissue stem cell bank Personalized medicine

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